Results 171 to 180 of about 53,182 (300)
Selection of chemically defined media for CHO cell fed-batch culture processes. [PDF]
Cytotechnology, 2017 Pan X +4 more
europepmc +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino +6 more
wiley +1 more source
Repeated Fed-Batch Culture Strategy for the Synthesis of Polyhydroxybutyrate (PHB) Biopolymers from Sugar Cane Juice Using Azotobacter vinelandii. [PDF]
Polymers (Basel)Dujjanutat P +2 more
europepmc +1 more source
Segmented linear modeling of CHO fed-batch culture and its application to large scale production. [PDF]
Biotechnol Bioeng, 2017 Ben Yahia B +3 more
europepmc +1 more source
Thermodynamic Evaluation of Dual Substrate Growth
Biotechnology and Bioengineering, EarlyView.ABSTRACT Various C₁–C₂ compounds are increasingly available through electrochemical reduction of CO2. Although not always suitable as a sole substrate, these compounds can supplement a primary substrate like glucose to enhance microbial growth. Yet, the mechanisms underlying the effects of dual substrate consumption on growth rate and growth yield ...
Marit A. Verheijen +3 more
wiley +1 more source
Development of a chemically defined platform fed-batch culture media for monoclonal antibody-producing CHO cell lines with optimized choline content. [PDF]
Cytotechnology, 2018 Kuwae S, Miyakawa I, Doi T.
europepmc +1 more source
Nicotinamide Reverses the Warburg Effect in CHO Cell Culture
Biotechnology and Bioengineering, EarlyView.Abstract The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey +7 more
wiley +1 more source
Co-production of microbial oil and exopolysaccharide by the oleaginous yeast Sporidiobolus pararoseus grown in fed-batch culture. [PDF]
RSC Adv, 2018 Han M, Xu JZ, Liu ZM, Qian H, Zhang WG.
europepmc +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Reinforcement learning (RL) has been used to control a wide range of dynamic processes, especially ones that are too complex to model well or have stochastic environmental perturbations. Fed‐batch fermentations are subject to changes in starting cell growth rates and process variations that can affect cell growth and secreted target production.
Sai Harish Uthravalli +3 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Oxygen supply is a critical parameter in 3D cell cultivation using bioreactors. Since bioreactor designs often prioritise practical constraints, understanding the oxygen supply dynamics of the media is crucial for achieving either uniform or spatially controlled oxygen delivery.
Franziska Alt +4 more
wiley +1 more source