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Generic model control of an Escherichia coli fed-batch culture
2019 23rd International Conference on System Theory, Control and Computing (ICSTCC), 2019Generic model control (GMC), a model-based adaptive control strategy, is applied to a fed-batch high cell density cultivation of Escherichia coli, with biomass production maximization as an objective. A macroscopic model based on the overflow metabolism assumption is used, considering two metabolic pathways (respirative and respiro-fermentative), and ...
Abadli, Merouane +4 more
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Controlling glycation of recombinant antibody in fed‐batch cell cultures
Biotechnology and Bioengineering, 2011AbstractProtein glycation is a non‐enzymatic glycosylation that can occur to proteins in the human body, and it is implicated in the pathogenesis of multiple chronic diseases. Glycation can also occur to recombinant antibodies during cell culture, which generates structural heterogeneity in the product. In a previous study, we discovered unusually high
Inn H, Yuk +9 more
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Simulation of L/A control in fed‐batch culture of baker's yeast
Biotechnology and Bioengineering, 1992AbstractL/A controllers have extended their use from continuous to fed‐batch fermentation where the control is applied from the start of an initial batch phase. As opposed to proportional integral derivative (PID) controllers where even a startup procedure is recommended prior to fed‐batch, the L/A controller is not upset by an early connection.
P, Dantigny, M, Lakrori
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Comparison of Fed-batch Strategies in Hybridoma Cultures
2008The classical cell culture process in stirred tank or airlift reactors is still the mostly used large scale production system. Fed-batch processes with different feeding strategies have been investigated to improve the productivity of hybridoma cultures.
J. O. Schwabe, Ines Wilkens, R. PÖrtner
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Control of endotoxin release in Escherichia coli fed-batch cultures
Bioprocess and Biosystems Engineering, 2004High amounts of outer membrane (OM) components were released in glucose-limited fed-batch (GLFB) cultures at 37 degrees C at specific growth rates approaching 0.05 h(-1). Endotoxin analyses from a 20 degrees C GLFB culture gave similar results. An alternative fermentation technique, the temperature-limited fed-batch (TLFB) technique, reduced the ...
Marie, Svensson +4 more
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Application of an On‐Line Turbidimeter for the Automation of Fed‐Batch Cultures
Biotechnology Progress, 1993AbstractRecent advances in the technology of continuous in situ turbidity measurements in microbial cultivations are reviewed. Some characteristics of commercially available on‐line laser turbidimeters are estimated in relation to requirements of sensors for microbial cultures.
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Comparison of optimization methods for fed-batch cultures of hybridoma cells
Bioprocess Engineering, 1997Two methods for the calculation of optimal trajectories for the input variables of a fed-batch culture of hybridoma cells are compared. It pointed out that a gradient method based on Pontryagins' minimum principle based yields a significant better performance with respect to computational effort and the calculated minimum than a dynamic programming ...
Roubos, J.A. +3 more
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Robust Control of Yeast Fed-Batch Cultures for Productivity Enhancement
IFAC Proceedings Volumes, 2009Abstract Abstract This work proposes a robust control strategy for the optimizing control of fed-batch cultures of S. cerevisae. The process dynamics is characterized by a nonlinear kinetic model based on the bottleneck assumption and ethanol inhibition for a possible excess of substrate feeding.
Coutinho Ferreira, Daniel +2 more
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Improvement of mammalian cell fed-batch culture
1995Typical features of mammalian cells grown in suspension culture are the limitation of growth and very often the initiation of the cell death phase immediately after a critical cell density has been achieved. However, both features can be influenced to a certain extent by fortifying the growth medium as well as by feeding the culture with nutrients ...
E. J. Schlaeger, K. Christensen
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Regulation of glutamine synthetase in fed-batch cultures of Neurospora crassa
Biochemical and Biophysical Research Communications, 1977Abstract The effect of the nitrogen and carbon sources in the regulation of g l u tamine synthetase has been studied in fed-batch cultures of Neurospora crassa . The limitation of ammonium in an excess of the carbon source, leads to an accumulation of α-ketoglutarate and elevation of glutamine sy n thetase.
J, Limón-Lason +3 more
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