Results 201 to 210 of about 28,581 (261)

An adaptive control algorithm for fed‐batch culture

Biotechnology and Bioengineering, 1984
AbstractThe implementation of adaptive control for a fed‐batch culture in order to maximize the output of product based on a self‐adjusting model is discussed in the present work. Optimization methods were applied to the generalized mathematical model of a fed‐batch fermentation process to determine control algorithms that could be used for on‐line ...
J, Stanissis, D, Levisauskas
openaire   +2 more sources

Feed Optimization in Fed-Batch Culture

2013
Fed-batch processes are a current preference for the production of recombinant proteins in mammalian cells. The use of nutrient feeding prevents the depletion of important medium components and results in improved culture longevity and high cell and product yields.
Costa, A. R., Rodrigues, E., Henriques, Mariana, Oliveira, Rosário, Azeredo, Joana   +4 more
openaire   +3 more sources

Robust adaptive control of yeast fed-batch cultures

Computers & Chemical Engineering, 2008
Abstract Model-based control of bioprocesses is a difficult task due to the challenges associated with biological system modeling and the lack of on-line measurements. In this study, two robust controllers using minimal a priori process knowledge and minimal measurement information are designed to maximize biomass productivity in aerobic cultures ...
Renard, Frédéric, Vande Wouwer, Alain
openaire   +2 more sources

Fed-Batch Cultures

2013
Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal ...
Henry C. Lim, Hwa Sung Shin
openaire   +1 more source

Fed-Batch Culture Processes

2020
The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
openaire   +1 more source

Metabolically optimised BHK cell fed-batch cultures

Journal of Biotechnology, 2000
The aim of this work was the optimisation of a fed-batch culture by metabolic confinement of BHK21 cells producing an antibody/cytokine fusion protein with potential application in tumour-targeted therapy. Previous results showed that at very low nutrient concentrations, a metabolic shift towards more efficient metabolic pathways occurs.
H J, Cruz, J L, Moreira, M J, Carrondo
openaire   +2 more sources

Optimization of a Fed-batch Culture by Statistical Data Analysis

IFAC Proceedings Volumes, 1983
Abstract An algorithm for the optimization of a fermentation process was investigated using the combination of dynamic programming and a linear predictive procedure by regression analysis. It was applied to the fed-batch culture for glutamic acid production with ethanol feeding and was proved to be effective for solving the optimization problems ...
M. Kishimoto, T. Sawano, T. Yoshida, H. Taguchi   +3 more
openaire   +1 more source

Perchloroethylene utilization by methanogenic fed-batch cultures

Applied Biochemistry and Biotechnology, 1996
Anaerobic sludge granules from two different sources were maintained in serum bottles and fed at 3-d intervals in the presence of 0.2 ppm perchloroethylene (PCE). Following acclimation periods ranging from 48-79 d, PCE degradation was observed with 95% utilization in 3 d. Only granules amended with formate as a cosubstrate showed PCE-degrading activity,
Herve Garant, Lee R. Lynd
openaire   +2 more sources

Controlled fed-batch by tracking the maximal culture capacity

Journal of Biotechnology, 2007
Fed-batch processes are well established in the biotech industry. The major reason to apply this technique is to avoid overflow metabolism and/or accumulation of toxic substrates. The basic idea of this approach is to control the physiological state of the culture, rather than just the typically exponential feed rate profile, by challenging a fed-batch
Henes B, Sonnleitner B
openaire   +3 more sources

Fed-batch and continuous culture

1990
Abstract A variety of techniques has been developed for the submerged culture of microorganisms. Batch and fed-batch culture have been part of the art of fermentation since antiquity and are still used today for most industrial fermentations.
openaire   +1 more source