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Fed-batch culture technology

Biotechnology Advances, 1986
The use of fed-batch procedures offers distinct advantages over other modes of operation of bioreactors, and is a widely researched technique. These advantages are discussed; some uses of fed-batch procedures and the associated methods of modelling and control are reviewed.
B J, Minihane, D E, Brown
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An analysis of extended and exponentially‐fed‐batch cultures

Biotechnology and Bioengineering, 1977
AbstractUnder certain conditions it is shown that an extended culture is equivalent to an exponentially‐fed‐batch culture, that an exponentially‐fed‐batch culture (and an extended culture) can be maintained at a steady state and that an exponentially‐fed‐batch culture may be mimicked by a continuous‐flow culture with a constant dilution rate ...
H C, Lim, B J, Chen, C C, Creagan
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An adaptive control algorithm for fed‐batch culture

Biotechnology and Bioengineering, 1984
AbstractThe implementation of adaptive control for a fed‐batch culture in order to maximize the output of product based on a self‐adjusting model is discussed in the present work. Optimization methods were applied to the generalized mathematical model of a fed‐batch fermentation process to determine control algorithms that could be used for on‐line ...
J, Stanissis, D, Levisauskas
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Robust adaptive control of yeast fed-batch cultures

Computers & Chemical Engineering, 2008
Abstract Model-based control of bioprocesses is a difficult task due to the challenges associated with biological system modeling and the lack of on-line measurements. In this study, two robust controllers using minimal a priori process knowledge and minimal measurement information are designed to maximize biomass productivity in aerobic cultures ...
Renard, Frédéric, Vande Wouwer, Alain
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Fed-Batch Cultures

2013
Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal ...
Henry C. Lim, Hwa Sung Shin
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Perchloroethylene utilization by methanogenic fed-batch cultures

Applied Biochemistry and Biotechnology, 1996
Anaerobic sludge granules from two different sources were maintained in serum bottles and fed at 3-d intervals in the presence of 0.2 ppm perchloroethylene (PCE). Following acclimation periods ranging from 48-79 d, PCE degradation was observed with 95% utilization in 3 d. Only granules amended with formate as a cosubstrate showed PCE-degrading activity,
Herve Garant, Lee R. Lynd
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