Results 251 to 260 of about 111,815 (303)

Controlled fed-batch by tracking the maximal culture capacity

Journal of Biotechnology, 2007
Fed-batch processes are well established in the biotech industry. The major reason to apply this technique is to avoid overflow metabolism and/or accumulation of toxic substrates. The basic idea of this approach is to control the physiological state of the culture, rather than just the typically exponential feed rate profile, by challenging a fed-batch
Bernhard, Henes, Bernhard, Sonnleitner
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Fed-batch and continuous culture ofPhaffia rhodozyma (Xanthophyllomyces dendrorhous)

Folia Microbiologica, 1998
The basidiomycetous yeastPhaffia rhodozyma was grown in batch, fed-batch and continuous culture, and some parameters governing growth and total carotenoid production were determined.
L M, Ducrey Santopietro, J F, Spencer, F, Siñeriz   +2 more
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Fed-Batch Culture Processes

2020
The cells used in cell culture processes are all derived from animals. Their genetic and epigenetic control circuits and their physiology have evolved to carry out the physiological functions of the tissue from which they were derived, not to sustain themselves and proliferate in in vitro culture.
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Fed-batch hairy root cultures within situ separation

Biotechnology and Bioprocess Engineering, 1999
Fed-batch cultures ofL. erythrorhizon hairy root were carried out by controlling sucrose concentration and media conductivity in a shake flask and a modified stirred tank reactor. For the efficient product recovery from the culture,in situ adsorption by XAD-2 was also conducted.
Sang Jun Sim, Ho Nam Chang
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Improvement of mammalian cell fed-batch culture

1995
Typical features of mammalian cells grown in suspension culture are the limitation of growth and very often the initiation of the cell death phase immediately after a critical cell density has been achieved. However, both features can be influenced to a certain extent by fortifying the growth medium as well as by feeding the culture with nutrients ...
E. J. Schlaeger, K. Christensen
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Robust adaptive control of yeast fed-batch cultures

Computers & Chemical Engineering, 2008
Abstract Model-based control of bioprocesses is a difficult task due to the challenges associated with biological system modeling and the lack of on-line measurements. In this study, two robust controllers using minimal a priori process knowledge and minimal measurement information are designed to maximize biomass productivity in aerobic cultures ...
F. Renard, A. Vande Wouwer
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ROBUST ADAPTIVE CONTROL OF YEAST FED-BATCH CULTURES

IFAC Proceedings Volumes, 2006
Abstract A robust controller combining a feedforward compensator (for the measured disturbance) and a feedback RST controller is designed for the control of S. cerevisiae cultures. The controller is based on the linearization of Sonnleitner's model allowing a simple transfer function model to be derived, which describes the relation between the ...
F. Renard, A. Vande Wouwer, M. Perrier
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Fed-batch and continuous culture

1990
Abstract A variety of techniques has been developed for the submerged culture of microorganisms. Batch and fed-batch culture have been part of the art of fermentation since antiquity and are still used today for most industrial fermentations.
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Optimal switching control for microbial fed-batch culture

Nonlinear Analysis: Hybrid Systems, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Liu, Chongyang, Gong, Zhaohua, Feng, Enmin, Yin, Hongchao   +3 more
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Cell‐controlled hybrid perfusion fed‐batch CHO cell process provides significant productivity improvement over conventional fed‐batch cultures

Biotechnology and Bioengineering, 2017
ABSTRACTA simple method originally designed to control lactate accumulation in fed‐batch cultures of Chinese Hamster Ovary (CHO) cells has been modified and extended to allow cells in culture to control their own rate of perfusion to precisely deliver nutritional requirements.
Gregory W, Hiller, Ana Maria, Ovalle, Matthew P, Gagnon, Meredith L, Curran, Wenge, Wang   +4 more
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