Results 51 to 60 of about 996,244 (363)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

α-lipoic acid, tea polyphenols and their combined application affect the growth performance, biochemical indices, and inflammation-related indices of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus) ingests a high fat-diet

Aquaculture Reports
High-fat diets (HD) are extensively used in aquaculture due to saving feed cost, reducing protein level, and improve better fish growth and health conditions.
Hengyang Song, Xiangxiang Suo, Wanting Huang, Yubin Liu, Xiaojuan Huang, Wenshan Cai, Hao Liu, Beiping Tan, Xiaohui Dong   +8 more
doaj   +1 more source

Effects of Dietary Lipid Sources on Alleviating the Negative Impacts Induced by the Fishmeal Replacement With Clostridium autoethanogenum Protein in the Diet of Pacific White Shrimp (Litopenaeus vannamei)

Frontiers in Marine Science, 2022
This study evaluated the effects of lipid sources on the replacement of fishmeal with Clostridium autoethanogenum protein (CAP) in the diet of Pacific white shrimp (Litopenaeus vannamei).
Chaozhong Zheng, Shunlian Gong, Junming Cao, Junming Cao, Junming Cao, Xiaohui Dong, Xiaohui Dong, Xiaohui Dong, Shuyan Chi, Shuyan Chi, Shuyan Chi, Qihui Yang, Qihui Yang, Qihui Yang, Hongyu Liu, Hongyu Liu, Hongyu Liu, Shuang Zhang, Shuang Zhang, Shuang Zhang, Shiwei Xie, Shiwei Xie, Shiwei Xie, Beiping Tan, Beiping Tan, Beiping Tan   +25 more
doaj   +1 more source

Potentials of castor seed meal (Ricinus communis L.) as feed ingredient for Oreochromis niloticus [PDF]

, 2005
The potentials of castor seed (Ricinus communis) meal as feed ingredient for Oreochromis niloticus was determined by using boiled seeds to prepare five diets which were fed to the fish species.
Abdullahi, S.A., Agboola, O.E., Auta, J., Balogun, J.K.   +3 more
core  

Replacement of soybean meal with chestnut meal and corn meal improves the growth performance, feed utilization efficiencies, nutrient digestibility and body composition of fingerlings of Oreochromis niloticus [PDF]

, 2023
Nishat Azam, Muhammad Talha Ayub, Muhammad Kamran, Maryam Iqbal, Muhammad Nasir, Atif Yaqub   +5 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Effects of the replacement of fishmeal with defatted black soldier fly (Hermetia illucens) larvae meal in high lipid diets on growth, serum liver antioxidant and disease resistance in the hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂)

Aquaculture Reports
A previous study showed that high lipid (16 %) diet could reduce protein content from 50 % to 45 % without affecting growth performance of hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂).
Weibin Huang, Wanting Huang, Wenshan Cai, Hao Liu, Menglong Zhou, Beiping Tan, Hengyang Song, Xiaohui Dong   +7 more
doaj   +1 more source

PRR-Mediated Immune Response and Intestinal Flora Profile in Soybean Meal-Induced Enteritis of Pearl Gentian Groupers, Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂

Frontiers in Immunology, 2022
Pattern recognition receptors (PRRs) can recognize microbial-specific pathogen-associated molecular patterns, initiate signal cascade transduction, activate the expressions of host immunity and proinflammatory genes, and, ultimately, trigger an immune ...
Wei Zhang, Wei Zhang, Wei Zhang, Beiping Tan, Beiping Tan, Beiping Tan, Junming Deng, Junming Deng, Junming Deng, Qihui Yang, Qihui Yang, Qihui Yang, Shuyan Chi, Shuyan Chi, Shuyan Chi, Aobo Pang, Aobo Pang, Aobo Pang, Yu Xin, Yu Xin, Yu Xin, Yu Liu, Yu Liu, Yu Liu, Haitao Zhang   +24 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The positive effects of dietary inositol on juvenile hybrid grouper (♀Epinephelus fuscoguttatus × ♂ Epinephelus lanceolatu) fed high-lipid diets: Growth performance, intestinal digestive enzymes, tissue morphology, and intestinal microbiota

Aquaculture Reports
The aim of study was to explore the beneficial effects of adding inositol to high-lipid diets on intestinal digestive enzymes, tissue morphology, and intestinal microbiota in juvenile hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ Epinephelus lanceolatu)
Biao Li, Simiao Pan, Weibin Huang, Menglong Zhou, Hao Liu, Baiquan Lu, Hengyang Song, Wenshan Cai, Beiping Tan, Yuanzhi Yang, Xiaohui Dong   +10 more
doaj   +1 more source