Results 41 to 50 of about 4,106,941 (234)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Effects of dietary n-3HUFA levels on growth, antioxidant capacity, and ovarian development in Litopenaeus vannamei broodstock shrimp

Aquaculture Reports
The present study investigated the effects of dietary n-3 highly unsaturated fatty acids (n-3 HUFA) on the growth, antioxidant capacity, and ovarian development of female Litopenaeus vannamei broodstock. Five experimental diets with varying levels of n-3
Weibin Huang, Biao Li, Beiping Tan, Digen Qin, Zhiyue Li, Xintong Su, Yansheng Liu, Shuang Zhang, Shiwei Xie, Xiaohui Dong   +9 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

α-lipoic acid, tea polyphenols and their combined application affect the growth performance, biochemical indices, and inflammation-related indices of hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus) ingests a high fat-diet

Aquaculture Reports
High-fat diets (HD) are extensively used in aquaculture due to saving feed cost, reducing protein level, and improve better fish growth and health conditions.
Hengyang Song, Xiangxiang Suo, Wanting Huang, Yubin Liu, Xiaojuan Huang, Wenshan Cai, Hao Liu, Beiping Tan, Xiaohui Dong   +8 more
doaj   +1 more source

Effects of Dietary Lipid Sources on Alleviating the Negative Impacts Induced by the Fishmeal Replacement With Clostridium autoethanogenum Protein in the Diet of Pacific White Shrimp (Litopenaeus vannamei)

Frontiers in Marine Science, 2022
This study evaluated the effects of lipid sources on the replacement of fishmeal with Clostridium autoethanogenum protein (CAP) in the diet of Pacific white shrimp (Litopenaeus vannamei).
Chaozhong Zheng, Shunlian Gong, Junming Cao, Junming Cao, Junming Cao, Xiaohui Dong, Xiaohui Dong, Xiaohui Dong, Shuyan Chi, Shuyan Chi, Shuyan Chi, Qihui Yang, Qihui Yang, Qihui Yang, Hongyu Liu, Hongyu Liu, Hongyu Liu, Shuang Zhang, Shuang Zhang, Shuang Zhang, Shiwei Xie, Shiwei Xie, Shiwei Xie, Beiping Tan, Beiping Tan, Beiping Tan   +25 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effects of the replacement of fishmeal with defatted black soldier fly (Hermetia illucens) larvae meal in high lipid diets on growth, serum liver antioxidant and disease resistance in the hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂)

Aquaculture Reports
A previous study showed that high lipid (16 %) diet could reduce protein content from 50 % to 45 % without affecting growth performance of hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂).
Weibin Huang, Wanting Huang, Wenshan Cai, Hao Liu, Menglong Zhou, Beiping Tan, Hengyang Song, Xiaohui Dong   +7 more
doaj   +1 more source

PRR-Mediated Immune Response and Intestinal Flora Profile in Soybean Meal-Induced Enteritis of Pearl Gentian Groupers, Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂

Frontiers in Immunology, 2022
Pattern recognition receptors (PRRs) can recognize microbial-specific pathogen-associated molecular patterns, initiate signal cascade transduction, activate the expressions of host immunity and proinflammatory genes, and, ultimately, trigger an immune ...
Wei Zhang, Wei Zhang, Wei Zhang, Beiping Tan, Beiping Tan, Beiping Tan, Junming Deng, Junming Deng, Junming Deng, Qihui Yang, Qihui Yang, Qihui Yang, Shuyan Chi, Shuyan Chi, Shuyan Chi, Aobo Pang, Aobo Pang, Aobo Pang, Yu Xin, Yu Xin, Yu Xin, Yu Liu, Yu Liu, Yu Liu, Haitao Zhang   +24 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source