Results 51 to 60 of about 88,503 (314)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Feedback stabilization of parabolic systems with bilinear controls

Electronic Journal of Differential Equations, 2011
In this article, we study infinite-bilinear systems, and consider a decomposition of the state space via the spectral properties of the systems.
Mohamed Ouzahra
doaj  

Boundary feedback stabilization of quasilinear hyperbolic systems with zero characteristic speed

Mathematical Modelling and Analysis
In this paper, we investigate the boundary feedback stabilization of a quasilinear hyperbolic system with zero characteristic speed and a partially dissipative structure.
Zhiqiang Wang, Wancong Yao
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Event-Triggered Control for the Stabilization of Probabilistic Boolean Control Networks

Complexity, 2018
This paper realizes global stabilization for probabilistic Boolean control networks (PBCNs) with event-triggered state feedback control (ETSFC). Via the semitensor product (STP) of matrices, PBCNs with ETSFC are converted into discrete-time algebraic ...
Shiyong Zhu, Jungang Lou, Yang Liu, Yuanyuan Li, Zhen Wang   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

An Energy-Balancing Perspective of Interconnection and Damping Assignment Control of Nonlinear Systems [PDF]

, 2003
Stabilization of nonlinear feedback passive systems is achieved assigning a storage function with a minimum at the desired equilibrium. For physical systems a natural candidate storage function is the difference between the stored and the supplied ...
Ortega, Romeo,, Scherpen, Jacquelien M.A.,, Dimitri Jeltsema, Jeltsema, Dimitri,, Jeltsema, Dimitri, Scherpen, Jacquelien M.A., Jacquelien M.A. Scherpen, Ortega, Romeo, Romeo Ortega   +8 more
core   +1 more source

Stabilization of a Class of Fractional Order Systems With Both Uncertainty and Disturbance

IEEE Access, 2021
This paper investigates the stabilization problem of fractional order systems with both model uncertainty and external disturbance. By combining the linear feedback control method, the dynamic feedback control method, and the uncertainty and disturbance ...
Runlong Peng, Cuimei Jiang, Rongwei Guo
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Reverse quantum state engineering using electronic feedback loops

New Journal of Physics, 2012
We propose an all-electronic technique to manipulate and control interacting quantum systems by unitary single-jump feedback conditioned on the outcome of a capacitively coupled electrometer and, in particular, a single-electron transistor.
Gerold Kießlich, Clive Emary, Gernot Schaller, Tobias Brandes   +3 more
doaj   +1 more source