Results 101 to 110 of about 245,531 (271)
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Compliments Given by a Teacher in Symphpnia Music School Surabaya to High-, Mid-, and Low-ability Students [PDF]
, 2013 This research aimed at observing compliment and non-compliment feedbacks between a teacher at a private music school and her students who had different abilities. The data were the recorded piano lesson of each student and the analysis was focused on the
Dwi-Nugroho, A. (Aylanda) +1 more
core
Nurturing Breakthroughs: Lessons from Complexity Theory
, 2007 A general theory of innovation and progress in human society is outlined, based on the combat between two opposite forces (conservatism/inertia and speculative herding "bubble" behavior).
Sornette, Didier
core +2 more sources
Japanese Heart Journal, 1996 The macula densa, a plaque of specialized tubular epithelial cells located in the distal tubule, monitors the NaCl concentration of the tubular fluid and sends an as of yet unidentified signal to control glomerular hemodynamics. In this mechanism, called tubuloglomerular feedback (TGF), an increase in NaCl concentration at the macula densa constricts ...
S, Ito, K, Abe
openaire +3 more sources
Hysteresis of the Antarctic Ice Sheet With a Coupled Climate‐Ice‐Sheet Model
Geophysical Research LettersThe stability of the Antarctic ice sheet under different fixed CO2 levels and orbital configurations is explored using a coupled climate‐ice sheet model, starting from either a pre‐industrial ice sheet or an ice‐free, isostatically rebounded geometry ...
G. Leloup +4 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Experiments and a model for pilot dynamics with visual and motion inputs [PDF]
Multimodality pilot model for visual and motion feedbacks derived from simulator ...
Alex, F. R. +2 more
core +1 more source
Light-driven liquid crystalline nonlinear oscillator under optical periodic forcing
, 2007 An all-optically driven strategy to govern a liquid crystalline collective molecular nonlinear oscillator is discussed. It does not require external feedbacks of any kind while the oscillator and a time-depending perturbation both are sustained by ...
A. Pikovsky +5 more
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source