Results 101 to 110 of about 246,352 (271)

Irrigation experiments in the lab: trust, environmental variability, and collective action

Ecology and Society, 2015
Research on collective action and common-pool resources is extensive. However, little work has concentrated on the effect of variability in resource availability and collective action, especially in the context of asymmetric access to resources.
Jacopo A. Baggio, Nathan D. Rollins, Irene Pérez, Marco A. Janssen   +3 more
doaj   +1 more source

Tubuloglomerular Feedback.

Japanese Heart Journal, 1996
The macula densa, a plaque of specialized tubular epithelial cells located in the distal tubule, monitors the NaCl concentration of the tubular fluid and sends an as of yet unidentified signal to control glomerular hemodynamics. In this mechanism, called tubuloglomerular feedback (TGF), an increase in NaCl concentration at the macula densa constricts ...
S, Ito, K, Abe
openaire   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Hysteresis of the Antarctic Ice Sheet With a Coupled Climate‐Ice‐Sheet Model

Geophysical Research Letters
The stability of the Antarctic ice sheet under different fixed CO2 levels and orbital configurations is explored using a coupled climate‐ice sheet model, starting from either a pre‐industrial ice sheet or an ice‐free, isostatically rebounded geometry ...
G. Leloup, A. Quiquet, D. M. Roche, C. Dumas, D. Paillard   +4 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Telecoupling: A new frontier for global sustainability

Ecology and Society, 2018
Telecoupling refers to socioeconomic and environmental interactions between distant coupled human and natural systems, and has become more extensive and intensive in the globalized era.
Vanessa Hull, Jianguo Liu
doaj   +1 more source

Experiments and a model for pilot dynamics with visual and motion inputs [PDF]

Multimodality pilot model for visual and motion feedbacks derived from simulator ...
Alex, F. R., Peters, R. A., Stapleford, R. L.   +2 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Detection and Filtering of Collaborative Malicious Users in Reputation System using Quality Repository Approach [PDF]

, 2013
Online reputation system is gaining popularity as it helps a user to be sure about the quality of a product/service he wants to buy. Nonetheless online reputation system is not immune from attack.
HK, Jnanamurthy, Singh, Sanjay
core