Results 51 to 60 of about 769 (206)

Spontaneous bone infarction of the distal femur in a patient with Cushing's disease: a case report

Bone Reports, 2021
Avascular necrosis of the femoral head is a well-known complication of treatment with high dosage glucocorticoids and has been described in a few patients with Cushing's syndrome.
Pepijn van Houten, Jacky de Rooy, Ingrid van der Geest, Romana Netea-Maier, Annenienke van de Ven   +4 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Relationship of idiopathic femoral head necrosis with blood lipid metabolism and coagulation function: A propensity score-based analysis

Frontiers in Surgery, 2023
BackgroundNontraumatic osteonecrosis of the femoral head (ONFH) can be corticosteroid-induced, alcohol-induced, and idiopathic ONFH (IONFH). Although corticosteroid- and alcohol-induced ONFH has been investigated extensively regarding its relationship ...
Xiaolong Yu, Shengtao Zhang, Bin Zhang, Min Dai   +3 more
doaj   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Role of valgus osteotomy in old fracture neck of femur: A retrospective cohort study

MRIMS Journal of Health Sciences, 2023
Background: Nonunion fracture of the neck of the femur remains an unsolved issue owing to peculiar vascular anatomy and the relationship of weight transmission to fracture pattern stability.
Tanmoy Mohanty, Suvam Choudhury, Braja Sundar Sahoo, Ramesh Chandra Maharaj, Debi Prasad Nanda   +4 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Ayurvedic management of Asthimajja gata vata w.s.r to AVN of head of femur – A case study

, 2023
Avascular necrosis (AVN) of the bone is a condition characterized by the death or necrosis of bone tissue, accompanied by structural changes. It is also referred to as osteonecrosis or ischemic necrosis of the bone. It is mostly seen in patients having a
M Parappagoudra, Mahesh, Patil, Dinesh, G, Anjali, G, Dash   +3 more
core   +1 more source

The tiger salamander as a promising alternative model organism to the axolotl for fracture healing and regenerative biology research

The Anatomical Record, EarlyView.
Abstract Scientists have been captivated by the ability to regenerate, focusing on uncovering the mechanisms of epimorphic regeneration and applying them to human medicine. The axolotl (Ambystoma mexicanum) has become the most intensively studied model in tetrapod regeneration research, particularly concerning limb regeneration.
Vivien Bothe, Nadia Fröbisch
wiley   +1 more source

AVASCULAR NECROSIS COMPLICATING UNDISPLACED FRACTURES OF THE NECK OF FEMUR 1N CHILDREN

, 1959
1. Three cases are reported of avascular necrosis of the head of the femur after undisplaced fractures of the neck of the femur in childhood. 2. It is suggested that the diaphysial vessels play a more important part in the supply of the epiphysis than ...
F. C. Durbin
core   +1 more source

Abnormal Lipid Profile in Fast-Growing Broilers With Spontaneous Femoral Head Necrosis

Frontiers in Physiology, 2021
This study investigated lipid metabolism in broilers with spontaneous femoral head necrosis (FHN) by determining the levels of markers of the blood biochemistry and bone metabolism.
Rubin Fan, Kangping Liu, Zhenlei Zhou
doaj   +1 more source