Results 51 to 60 of about 53,591 (265)

A histological study of idiopathic avascular necrosis of the head of the femur [PDF]

, 1979
We have studied the histological appearances of forty femoral heads with idiopathic avascular necrosis. The characteristic histopathological changes of recurrent necrosis were present in 83 per cent.
A Inoue, K Ono
core   +1 more source

[Femur head preserving therapy, using vascular pedicled iliac bone graft, in segmental femoral head necrosis].

Der Orthopade, 1998
Various therapeutic options have been proposed in the treatment of femoral head necrosis ranging from conservative management to total hip arthroplasty.
O. Kern, C. Klöckner, U. Weber
semanticscholar   +1 more source

Avascular necrosis of the femoral head as the first manifestation of acute lymphoblastic leukemia [PDF]

, 2006
PubMedID: 16502568Avascular necrosis of bone is a well-described complication of cancer chemotherapy containing corticosteroids and has been observed in lymphomas and acute lymphoblastic leukemia (ALL). This study reports the case of a young male patient
Öçal F., Gürkan E., Yildiz I.
core   +1 more source

Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats

Drug Design, Development and Therapy, 2021
Background Osteonecrosis of the femoral head (ONFH) seriously affects the quality of life and labor ability of patients. It is urgent and vital to find the methods for necrosis clinical treatment.
Ke Rong, Xiaoliu Li, Weimin Jiang, Xu-hua Wu, Qingquan Xia, Jie Chen, Xiaofan Yin   +6 more
semanticscholar   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

[Partial femur head necrosis in adults--results with intertrochanteric osteotomy and revascularization] [PDF]

, 1990
Osteotomy and revascularization have both been used for many years in the therapy of partial aseptic necrosis of the femoral head in the adult. We first attempted a combination of the two techniques in 1978.
Lippuner, K, Ganz, R, Büchler, U
core  

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

The effect of slip grade and chronicity on the development of femur avascular necrosis in surgically treated slipped capital femoral epiphyses

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: We investigated the relationship between the grade and chronicity (acute-chronic) of the slip and the development of avascular necrosis (AVN) of the femoral head after surgery for slipped capital femoral epiphysis (SCFE).\nMethods: The study ...
Yakup Yildirim, Severino Bautista, Richard S. Davidson   +2 more
doaj  

Ayurvedic Management of Avascular Necrosis of head of Femur: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Avascular Necrosis (AVN) is a pathological condition characterised by a reduction in the blood supply to the subchondral bone, leading to the degenerative condition of the bone, marked by the death of cellular components of the bone.
Tanika Yadav, Vaishali Kuchewar, Pankaj Yadav   +2 more
doaj   +1 more source