Results 101 to 110 of about 5,495 (171)

Effects of long-term d-fenfluramine treatment on energy metabolism in rats

, 1993
The effects of chronic intragastric administration of the anorectic agent d-fenfluramine on energy metabolism and nutrient concentrations were investigated at rest and during swimming.
Zijlstra, Willem G., Leuvenink, Henri, Steffens, Anton B., Leest, Jaap van der,, Scheurink, Anton J.W.,, Leuvenink, Henri; id_orcid, Benthem, Lambertus, Leest, Jaap van der, Steffens, Anton B.,, Zijlstra, Willem G.,, Scheurink, Anton J.W., Benthem, Lambertus,, Leuvenink, Henry,   +12 more
core   +1 more source

Possible involvement of endogenous opiates in the tolerance to the anorectic effect of fenfluramine

, 1984
Repeated administration of fenfluramine leads to a rapid and progressive loss of its effectiveness in reducing food intake. The animals tolerant to the anorectic effect of fenfluramine had markedly low basal hypothalamic serotonin (5-HT) levels.
Dellavedova L, Parenti M, Tirone F, Groppetti A   +3 more
core  

Corrigendum: Improving therapy of pharmacoresistant epilepsies: The role of fenfluramine

Frontiers in Pharmacology, 2023
Gianluca Dini, Eleonora Tulli, Giovanni Battista Dell’Isola, Elisabetta Mencaroni, Giuseppe Di Cara, Pasquale Striano, Pasquale Striano, Alberto Verrotti   +7 more
doaj   +1 more source

Optimal dose of fenfluramine in adjuvant treatment of drug-resistant epilepsy: evidence from randomized controlled trials

Frontiers in Neurology
ObjectiveSeveral clinical trials have suggested that fenfluramine (FFA) is effective for the treatment of epilepsy in Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS). However, the exploration of its optimal target dose is ongoing. This study aimed
Yingchun Xu, Deng Chen, Ling Liu
doaj   +1 more source

Dopamine Agonists Prevent or Counteract the Suppression of Brain Stimulation Reward by Fenfluramine

, 1995
The interaction between the serotonin (5-HT) and the dopamine (DA) systems in the modulation of intracranial self-stimulation (ICSS), a DA-dependent behavior, was investigated.
Olds, M. E.
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HPA-AXIS HORMONES AND PROLACTIN RESPONSES TO DEXTRO-FENFLURAMINE IN DEPRESSED-PATIENTS AND HEALTHY CONTROLS

, 1991
1. Like other authors we have established disturbances in central serotonergic neurotransmission in severely depressed patients by implementing hypothalamic pituitary adrenal (HPA)-axis hormones and prolactin responses to serotonin agonists or precursors.
VANDERVORST, Carine, SUY, E, DHONDT, P, MINNER, B, Maes, Michael, RAUS, Jef   +5 more
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The Metabolism and Kinetics of Fenfluramine, its Optical Isomers and a Structural Analogue, Benfluorex. [PDF]

, 2020
Following oral administration of [14C]-dl-fenfluramine (60mg) to human volunteers greater than 90% of the dose was recovered in urine within three days after dosing. Metabolism was extensive. The identified metabolites were the products of N-deethylation
Richards, Ray.
core  

Evidence for a difference in mechanism of action between fenfluramine- and amphetamine-induced anorexia

, 1973
The influence of drugs, active on 5-hydroxytryptamine (5-HT) mechanisms, has been examined on the anorexigenic activity of fenfluramine and (+)-amphetamine in rats trained to consume their daily food ration during 6 h. Chlorimipramine, which inhibits the
J Scheel-Krüger, Sune Jespersen
core   +1 more source

Efficacy and safety of pharmacological and non-pharmacological therapies in Lennox-Gastaut syndrome: a systematic review and network meta-analysis

Frontiers in Pharmacology
ObjectiveThis study aimed to evaluate the efficacy and safety of antiepileptic drugs and non-pharmacological treatments in patients with Lennox-Gastaut syndrome (LGS).MethodsWe conducted a systematic search of the PubMed, Embase, Cochrane, and Web of ...
Zhengyan Zhu, Zhengyan Zhu, Zhenpan Zhang, Zhenpan Zhang, Wei Xiao, Wei Xiao, Wei Xiao, Chunhua Wang, Chunhua Wang, Risheng Liang, Risheng Liang   +10 more
doaj   +1 more source

Some 5-hydroxytryptamine-like actions of fenfluramine: a comparison with (+)-amphetamine and diethylpropion

, 1971
The 5-hydroxytryptamine (5-HT)-like effects of fenfluramine have been investigated in mice in two different experiments. In a behavioural test in mice pretreated with tranylcypromine, fenfluramine caused stereotyped changes which were similar to those ...
A B WILSON, ELIZABETH BOXALL, SUSAN R MAYER, P J SOUTHGATE   +3 more
core   +1 more source