Results 71 to 80 of about 5,495 (171)

Fenfluramine-induced pulmonary vasoconstriction: role of serotonin receptors and potassium channels

, 2001
The anorexic agent fenfluramine considerably increases the risk of primary pulmonary hypertension. The mechanism of this effect is unknown. The appetite-reducing action of fenfluramine is mediated by its interaction with the metabolism of serotonin [5 ...
Jan Šimák, Simona Bělohlávková, Olga Hniličková, Alena Kokešová, Václav Hampl   +4 more
core   +1 more source

Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first‐line add‐on therapies for seizures in Dravet syndrome: A network meta‐analysis

Epilepsia Open
Objectives Stiripentol, fenfluramine, and cannabidiol are licensed add‐on therapies to treat seizures in Dravet Syndrome (DS). There are no direct or indirect comparisons assessing their full licensed dose regimens, across different jurisdictions, as ...
Renzo Guerrini, Catherine Chiron, Delphine Vandame, Warren Linley, Toby Toward   +4 more
doaj   +1 more source

Fenfluramine Challenge Test in Obsessive-Compulsive Disorder - First Results

Acta Medica, 1997
Obsessive-compulsive disorder is a chronic psychiatric illness, affecting up to 3% of the general population, to the midle of 60-th it was supposed to be untreatable. Antidepressant pharmacotherapy is one of the treatment alternatives today.
Vladimír Pidrman, Ivan Tůma
doaj   +1 more source

From first seizure to specific antiseizure medication in Dravet syndrome: Quantifying delays in the DS'coverED study

Epilepsia Open, EarlyView.
Abstract Objective Dravet syndrome (DS) is a rare early‐onset developmental and epileptic encephalopathy with persistent delays between seizure onset and diagnosis. The DS'coverED study aimed to characterize current diagnostic timelines by examining each step and its duration, identifying residual barriers, and actionable solutions to optimize the ...
Loucas Christodoulou, Maria Ballarà Petitbò, Sergio Aguilera Albesa, Simona Borroni, Perrine Hugon, Ratna Kumar, Tullio Messana, Pierre Meyer, Frédéric Villéga, Kerstin A. Klotz   +9 more
wiley   +1 more source

The Role of the Sympathetic Nervous System in the Hypothermic Effect of d-Fenfluramine [PDF]

, 2002
Experiments in this dissertation were conducted to characterize the effects of d-fenfluramine on body temperature and the mechanisms by which d-fenfluramine alter body temperature.
Subramanian, Srividya
core  

Inhibition of gastric emptying and feeding by fenfluramine

, 1986
To assess the mechanism by which the anorectic agent fenfluramine influences feeding, we examined in Macaca mulatta the effect of intragastric fenfluramine (2 mg/kg) on both feeding and the gastric emptying of saline and glucose test meals.
T. H. Moran, P. H. Robinson, P. R. McHugh   +2 more
core   +1 more source

Fenfluramine in refractory epileptic encephalopathies: multi-mechanistic insights and future directions—a comprehensive review

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Refractory epileptic encephalopathies are defined as the severe, childhood-onset epilepsies associated with drug-resistant periodic seizures, neurodevelopmental disability, behavioral problems, and escalate the risk of sudden unexpected death in epilepsy
Muhammad Shahzaib Rasheed, Muhammad Bilal, Muhammad Zakriya Akhtar, Azka Sabir, Mubashira Naz, Shams ur Rehman, Talha Ramzan, Mirza Noman Abbas, Usama Usama   +8 more
doaj   +1 more source

A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function

Brazilian Journal of Medical and Biological Research, 2003
Breeding for high and low hypothermic responses to systemic administration of a serotonin1A (5-HT1A) receptor agonist (8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT) has resulted in high DPAT-sensitive (HDS) and low DPAT-sensitive (LDS) lines of rats,
L.E. Gonzalez, M.A. Parada, S. Tucci, L. Teneud, D.H. Overstreet, L. Hernandez   +5 more
doaj   +1 more source

Reply to: Does the generalized paroxysmal fast activity‐underrepresented cluster represent Lennox–Gastaut syndrome or other severe developmental and epileptic encephalopathies?

Epilepsia, EarlyView.
Emanuele Cerulli Irelli, Marco Perulli, Maria S. Borioni, Adolfo Mazzeo, Carlo Di Bonaventura, Domenica I. Battaglia   +5 more
wiley   +1 more source

Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis

Respiratory Research, 2002
Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary hypertension (PH).
Adnot Serge, Eddahibi Saadia
doaj