Results 1 to 10 of about 12,682 (143)

Fenofibrate enhances lipid deposition via modulating PPARγ, SREBP-1c, and gut microbiota in ob/ob mice fed a high-fat diet

Frontiers in Nutrition, 2022
Obesity is characterized by lipid accumulation in distinct organs. Presently, fenofibrate is a commonly used triglyceride-lowering drug. This study is designed to investigate whether long-term fenofibrate intervention can attenuate lipid accumulation in ...
Ying Zhang, Xiu-Bin Jia, Yun-Chao Liu, Wen-Qian Yu, Yan-Hong Si, Yan-Hong Si, Shou-Dong Guo   +6 more
doaj   +1 more source

Long-Term Fenofibrate Treatment Stimulates the Phenotypic Microevolution of Prostate Cancer Cells In Vitro

Pharmaceuticals, 2022
Fenofibrate is a widely used anti-hyperlipidemic agonist of peroxisome proliferator-activated receptor alpha (PPARα). As a metabolic blocker, fenofibrate interferes with cancer promotion/progression via its misbalancing effects on cellular metabolism ...
Karolina W. Warzecha, Maciej Pudełek, Jessica Catapano, Zbigniew Madeja, Jarosław Czyż   +4 more
doaj   +1 more source

Fenofibrate for the prevention of progression of non-proliferative diabetic retinopathy: review, consensus recommendations and guidance for clinical practice [PDF]

International Journal of Ophthalmology, 2022
The prevalence of diabetic retinopathy (DR), and associated morbidity is high in the Asia-Pacific region. Emerging evidence suggests a potential role for fenofibrate in the prevention of progression of DR, especially in patients with cardiovascular risk,
Nor Fariza Ngah, Nor Asiah Muhamad, Roslin Azni Abdul Aziz, Shelina Oli Mohamed, Nor Azita Ahmad Tarmizi, Azian Adnan, Zalifah Zakiah Asnir, Zanariah Hussein, Hui Foo Siew, Masni Mohamed, Noor Aliza Lodz, Vijayamala Valayatham   +11 more
doaj   +1 more source

Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice [PDF]

Diabetes & Metabolism Journal, 2022
Background Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and diabetes. Peroxisomes are single membrane-enclosed organelles that play a role in the metabolism of lipid and reactive oxygen species.
Songling Jiang, Md Jamal Uddin, Xiaoying Yu, Lingjuan Piao, Debra Dorotea, Goo Taeg Oh, Hunjoo Ha   +6 more
doaj   +1 more source

The effects of simvastatin and fenofibrate on malondialdehyde and reduced glutathione concentrations in the plasma, liver, and brain of normolipidaemic and hyperlipidaemic rats

Arhiv za Higijenu Rada i Toksikologiju, 2023
The objective of study was to investigate the effects of different doses of simvastatin and fenofibrate on malondialdehyde (MDA) and reduced glutathione (GSH) in the plasma, liver, and brain tissue of male normolipidaemic and hyperlipidaemic rats ...
Vukšić Antonija, Rašić Dubravka, Žunec Suzana, Božina Tamara, Konjevoda Paško, Lovrić Jasna, Bilušić Marinko, Bradamante Vlasta   +7 more
doaj   +1 more source

Fenofibrate Ameliorated Systemic and Retinal Inflammation and Modulated Gut Microbiota in High-Fat Diet-Induced Mice

Frontiers in Cellular and Infection Microbiology, 2022
Fenofibrate, as a lipid-lowering drug, has been reported to have a protective effect on the retina independent with plasma lipid levels. This study aimed to investigate that the ameliorative effects of fenofibrate on systemic and retinal inflammation, as
Xue Wang, Xue Wang, Chaofeng Yu, Xiaomei Liu, Jiasong Yang, Jiasong Yang, Yuliang Feng, Yajun Wu, Yali Xu, Yihua Zhu, Wensheng Li, Wensheng Li   +11 more
doaj   +1 more source

Beneficial Effect of Fenofibrate and Silymarin on Hepatic Steatosis and Gene Expression of Lipogenic and Cytochrome P450 Enzymes in Non-Obese Hereditary Hypertriglyceridemic Rats

Current Issues in Molecular Biology, 2022
The efficacy of fenofibrate in the treatment of hepatic steatosis has not been clearly demonstrated. In this study, we investigated the effects of fenofibrate and silymarin, administered as monotherapy and in combination to existing hepatic steatosis in ...
Rostislav Vecera, Martin Poruba, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Zuzana Racova, Jan Soukop, Ludmila Kazdova   +8 more
doaj   +1 more source

Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: A randomized, open-label, multicenter clinical trial in Indian population

Indian Journal of Endocrinology and Metabolism, 2016
Introduction: Choline fenofibrate is a newly developed choline salt of fenofibric acid, which is more hydrophilic than fenofibrate. This study was initiated to evaluate the safety and efficacy of choline fenofibrate in comparison to micronized ...
Piyush Patel, Hanmant Barkate
doaj   +1 more source

Fenofibrate improves vascular endothelial function and contractility in diabetic mice

Redox Biology, 2019
Fenofibrate, a peroxisome proliferator-activated receptors α (PPARα) agonist, reduces vascular complications of diabetic patients but its protective mechanisms are not fully understood.
Nan Xu, Qin Wang, Shan Jiang, Qijing Wang, Weipeng Hu, Suhan Zhou, Liang Zhao, Lanyu Xie, Jianghua Chen, Anton Wellstein, En Yin Lai   +10 more
doaj   +1 more source

Fenofibrate diminishes the self-renewal and metastasis potentials of oral carcinoma stem cells through NF-κB signaling

Journal of the Formosan Medical Association, 2022
Background/Purpose: NF-κB family of transcription factors are the major contributors to malignant tumor progression, maintenance of cancer stemness, and enhancement of chemoresistance.
Tzu-Rong Su, Cheng-Chia Yu, Shih-Chi Chao, Chun-Chung Huang, Yi-Wen Liao, Pei-Ling Hsieh, Chuan-Hang Yu, Shih-Shen Lin   +7 more
doaj   +1 more source