Results 41 to 50 of about 12,682 (143)
Scientific Reports, 2021 Endothelial progenitor cells (EPCs) improve endothelial impairment, which in turn restores endothelial function in patients with heart failure (HF).
Wen-Pin Huang +5 more
doaj +1 more source
Indian Journal of Endocrinology and MetabolismIntroduction: Fenofibrate forms the standard of care for managing hypertriglyceridemia. Many of these patients have associated metabolic dysfunction-associated steatotic liver disease (MASLD). No systematic review and meta-analysis (SRM) has analysed the
Manoj Kumar +4 more
doaj +1 more source
Assessment of fenofibrate-methylation interactions on triglycerides using longitudinal family data
BMC Proceedings, 2018 Background Triglyceride (TG) concentrations decrease in response to fenofibrate treatment, and also are associated with DNA methylation. But how interactions between fenofibrate response and DNA methylation affect TGs remains unclear.
Jih-Chang Yu +2 more
doaj +1 more source
High density lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy. [PDF]
PLoS ONE, 2011 In a recent FIELD study the fenofibrate therapy surprisingly failed to achieve significant benefit over placebo in the primary endpoint of coronary heart disease events. Increased levels of atherogenic homocysteine were observed in some patients assigned
Laxman Yetukuri +10 more
doaj +1 more source
Long‐term remission in gout: Challenges and future opportunities
Rheumatology &Autoimmunity, EarlyView.Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng +10 more
wiley +1 more source
Molecular Cancer, 2010 Background Glioblastomas are characterized by rapid cell growth, aggressive CNS infiltration, and are resistant to all known anticancer regimens. Recent studies indicate that fibrates and statins possess anticancer potential.
Del Valle Luis +7 more
doaj +1 more source
PPAR Research, 2021 Lesions caused by high glucose (HG), hypoxia/reperfusion (H/R), and the coexistence of both conditions in cardiomyocytes are linked to an overproduction of reactive oxygen species (ROS), causing irreversible damage to macromolecules in the cardiomyocyte ...
Fabiola Cortes-Lopez +12 more
doaj +1 more source
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background Current evidence on incidence and progression rate of diabetic retinopathy reveals disparities across Australasia, and no pooled estimates are available to guide region‐wide planning. This review and meta‐analysis assesses the overall incidence, determinants and progression of diabetic retinopathy in Australasia.
Getasew Alemu Mersha +6 more
wiley +1 more source