Results 61 to 70 of about 29,324 (231)
, 2010 PURPOSE: The aim of this study was to examine the relation of late-stage age-related macular degeneration (AMD) with markers of systemic atherothrombosis. METHODS: A hospital-based case-control study of AMD was undertaken in London, UK.
A R Rudnicka +59 more
core +1 more source
Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.We presented herein that propadiene can chemodivergently form either an allylic moiety or a dienylic moiety under Pd catalysis. Embedding this reactivity pattern into photocatalysis with DHP as the initial radical source and styrene derivatives as the initial acceptor leads to multi‐component allylation and dienylation.
Yi‐Fei Yang +2 more
wiley +2 more sources
High density lipoprotein structural changes and drug response in lipidomic profiles following the long-term fenofibrate therapy in the FIELD substudy. [PDF]
PLoS ONE, 2011 In a recent FIELD study the fenofibrate therapy surprisingly failed to achieve significant benefit over placebo in the primary endpoint of coronary heart disease events. Increased levels of atherogenic homocysteine were observed in some patients assigned
Laxman Yetukuri +10 more
doaj +1 more source
PPAR Research, 2021 Lesions caused by high glucose (HG), hypoxia/reperfusion (H/R), and the coexistence of both conditions in cardiomyocytes are linked to an overproduction of reactive oxygen species (ROS), causing irreversible damage to macromolecules in the cardiomyocyte ...
Fabiola Cortes-Lopez +12 more
doaj +1 more source
SAFETY EVALUATION OF STATIN IN YOGYAKARTA, INDONESIA [PDF]
, 2009 Background : The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-Co-A) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum Low-Density Lipoprotein cholesterol (LDL-c)concentrations.
Anni, Anni +3 more
core
Lipid changes due to fenofibrate treatment are not associated with changes in DNA methylation patterns in the GOLDN study [PDF]
, 2015 Fenofibrate lowers triglycerides (TG) and raises high density lipoprotein cholesterol (HDLc) in dyslipidemic individuals. Several studies have shown genetic variability in lipid responses to fenofibrate treatment.
Bertha Hidalgo +10 more
core +2 more sources
Chemistry – A European Journal, EarlyView.ABSTRACT We explored aryl thianthrenation as a tool for directly incorporating multiple isotopes into molecular scaffolds starting from full isotopically labeled benzene. Stable isotope‐labeled (SIL) molecules are indispensable tools for investigating chemical and biological mechanisms and quantifying metabolites.
Alexandre Labiche +7 more
wiley +1 more source
Molecular Cancer, 2010 Background Glioblastomas are characterized by rapid cell growth, aggressive CNS infiltration, and are resistant to all known anticancer regimens. Recent studies indicate that fibrates and statins possess anticancer potential.
Del Valle Luis +7 more
doaj +1 more source
Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha Implications for the study of pharmaceutical modifiers of hypertriglyceridemia in mice [PDF]
, 2016 Mice have been used widely to define the mechanism of action of fibric acid derivatives. The fibrates are pharmacological agonists of the peroxisome proliferator-activated receptor α (PPARα), whose activation in human subjects promotes potent reduction ...
Chapman, M. John +6 more
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ChemSusChem, Volume 18, Issue 6, March 15, 2025.we have developed an electrochemical Ni−H catalyzed arylation coupling method of unactivated alkenes with aryl halides. The method displays broad functional group tolerance and proceeds under very mild conditions. Furthermore, aryl chlorides were also compatible substrates in this catalytic system. This conversion holds significant implications for the
Chao Xu, Ru‐Han A, Xiao‐Feng Wu
wiley +1 more source