Results 201 to 210 of about 87,215 (304)

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 122-138, July 2026.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

The positivity rate of opioid drug urine testing in an emergency department between 2016 and 2024, before and after the introduction of fentanyl testing. [PDF]

Subst Abuse Treat Prev Policy
Miron O, Zeltser D, Schreiber S, Peles E.   +3 more
europepmc   +1 more source

Prophylactic Dexmedetomidine Reduces Junctional Ectopic Tachycardia and Facilitates Postoperative Recovery in Pediatric Cardiac Surgery: A Systematic Review and Meta‐Analysis of Prospective Trials

Pediatric Anesthesia, Volume 36, Issue 7, Page 767-777, July 2026.
ABSTRACT Objective To evaluate the efficacy and safety of prophylactic dexmedetomidine in preventing Junctional Ectopic Tachycardia (JET) and its impact on postoperative recovery in pediatric congenital heart surgery, restricting analysis to prospective trials. Methods We systematically searched PubMed, Scopus, and CENTRAL through October 16, 2025, for
Michelle Singh, Arjun Anilkumar, Rohit Vondivillu Srinivasan, Jasim Abdul Jabbar, Naghul Malaichamy, Rethin Jayaraman   +5 more
wiley   +1 more source

AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder. [PDF]

Proc Natl Acad Sci U S A
Lallai V, Kho S, Martin AC, Fowler JP, Roach ML, Wang K, Laumann KN, Morrison TG, Palaniappan M, Bautista M, Mogul AS, Cheepluesak JE, Shrestha B, Lade DM, Lagomarsino JE, Narayan V, Uffens J, Lernhardt W, Mirzaei S, Jenkins I, Zavala AR, Lakey JRT, Tinder R, Fowler CD.   +23 more
europepmc   +1 more source

Unplanned Post‐Operative Pediatric Intensive Care Unit Admissions After Elective Upper Airway Procedures: A Retrospective Case–Control Study

Pediatric Anesthesia, Volume 36, Issue 7, Page 792-799, July 2026.
ABSTRACT Background Elective pediatric upper airway procedures are generally safe; however, some patients require unplanned pediatric intensive care unit admission, increasing care complexity. Aims To identify perioperative risk factors associated with unplanned pediatric intensive care unit admission following elective pediatric upper airway surgery ...
Hayes Stancliff, Michelle M. Basilious, Lisa R. Yoder, Conrad Krawiec, Terrence Murphy, Priti G. Dalal   +5 more
wiley   +1 more source

In utero ventriculosubgaleal shunt placement in a fetal lamb model: Phase 1 technical insights

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract Background Progressive ventriculomegaly and the resulting irreversible brain damage may be mitigated through timely diversion prenatal intervention. While ventriculosubgaleal shunt (VSGS) is commonly performed postnatally in premature infants, in utero placement is unexplored.
Shohra Qaderi, Weston T. Northam, Soner Duru, Eyal Krispin, Nikan Zargarzadeh, Ali Javinani, Jose L. Peiro, Hamidreza Forourtan, Braxton Forde, Syril James, Scott A. Shainker, Arthur Nedder, Brittany Pattison, Lana Vasung, Lucas Peiro, Ryne A. Didier, Michaela K. Farber, Sebastian Seifert, Darren B. Orbach, P. Ellen Grant, Ramen H. Chmait, Benjamin C. Warf, Kjersti Aagaard, Yves Ville, Alireza A. Shamshirsaz   +24 more
wiley   +1 more source

Anesthetic Management in Patients with Impella Devices: A Retrospective Review and Clinical Guide. [PDF]

Ann Card Anaesth
Yang H, Gouda D, Berg KB, Green K, Sundaresh S, Goudra B.   +5 more
europepmc   +1 more source

General Anaesthesia Versus Spinal Anaesthesia for Outpatient Total Hip and Knee Arthroplasty: A Randomised Trial Protocol

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Introduction Same‐day discharge after primary total hip arthroplasty (THA) and total knee arthroplasty (TKA) is increasing, but the optimal anaesthetic technique for outpatient pathways remains uncertain. Neuraxial anaesthesia is widely recommended based on observational evidence, whereas fast‐track programmes using short‐acting total ...
Erik Noppa, Karuna Dahlberg, Alex de Leon, Maziar Mohaddes, Anna Philipson, Peter Wildeman, Kristofer F. Nilsson   +6 more
wiley   +1 more source

Effects of Infraorbital Nerve Block with Dexmedetomidine-Added Bupivacaine on Intraoperative Opioid Consumption and Postoperative Analgesia During Endoscopic Transsphenoidal Surgery: A Prospective, Randomized, Double-Blind Controlled Trial. [PDF]

J Pain Res
Phothikun N, Pinon P, Saringkarinkul A, Polperm T, Plubnim N, Phothikun A.   +5 more
europepmc   +1 more source