Results 41 to 50 of about 81,387 (301)
Abuse potential of fentanyl and fentanyl analogues
BioImpactsIntroduction: In this perspective review, we evaluated the clinical management of fatal fentanyl overdose in several routes of administration, concentrating on both legally prescribed and illegally produced formulations. Methods: A literature search was conducted on Web of Science, PubMed, and Google Scholar databases, using the following keywords ...
Anusha Thumma +5 more
openaire +3 more sources
CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 13-26, January 2023., 2023 Abstract The pharmacokinetics (PKs) and safety of medications in particular groups can be predicted using the physiologically‐based pharmacokinetic (PBPK) model. Using the PBPK model may enable safe pediatric clinical trials and speed up the process of new drug research and development, especially for children, a population in which it is relatively ...
Xu Zhou +5 more
wiley +1 more source
Animals, 2021 Fentanyl was administered as a single intravenous bolus injection at 5 µg/kg to five koalas and fentanyl plasma concentrations for a minimum of 2 h were quantified by an enzyme-linked immunosorbent assay (ELISA).
Fumie Tokonami +2 more
doaj +1 more source
Rapid Communications in Mass Spectrometry, EarlyView., 2022 Rationale Carfentanil, an opioid 10K times more potent than morphine, has no licit clinical use. A powerful CNS depressant, it has been identified increasingly as the cause of overdose death in the United States. Because it is highly lipophilic, the law enforcement and medical communities have been concerned that responding personnel could be ...
Jonathan M. Oyler +2 more
wiley +1 more source
Computational and Structural Biotechnology Journal, 2022 Fentanyl and its analogs are selective agonists of the µ-opioid receptor (MOR). Among novel synthetic opioids (NSOs), they dominate the recreational drug market and are the main culprits for the opioid crisis, which has been exacerbated by the COVID-19 ...
Bing Xie, Alexander Goldberg, Lei Shi
doaj
United European Gastroenterology Journal, Volume 10, Issue 9, Page 973-982, November 2022., 2022 Abstract Background and Aims Magnetic resonance enterocolonography (MREC) and pan‐enteric capsule endoscopy (CE) offers visualization of the entire gastrointestinal tract in a single examination. We examined the diagnostic accuracy of MREC and CE in patients with suspected Crohn's disease (CD).
Jacob Broder Brodersen +5 more
wiley +1 more source
BMC Global and Public HealthBackground In the USA, many states, including Colorado, have increased criminal penalties for illicit opioid possession, which may alter overdose risk.
Katherine LeMasters +10 more
doaj +1 more source
Nigerian Postgraduate Medical Journal, 2022 Background: Insertion of laryngeal mask airway (LMA) with propofol in children may cause hypotension, laryngospasm and apnoea. Ketamine and fentanyl have been combined separately with propofol to prevent depression of cardiovascular system during LMA ...
Ajibade Okeyemi +5 more
doaj +1 more source
Advanced Science, EarlyView.This study develops an Au/S‐doped reduced graphene oxide (Au@S‐rGO) sensor for rapid fentanyl detection. DFT simulations and structural analysis confirm atomically dispersed Au/S configurations, enhancing catalytic activity. The sensor achieves a 9.7 nmol L−1 detection limit, 98–104% recovery in human serum, and 85.7–93.6% consistency with mass ...
Meng Li +9 more
wiley +1 more source
Indian Journal of Anaesthesia, 2019 Background and Aims: Fentanyl can facilitate controlled intraoperative hypotension by its sympatholytic effect in patients undergoing functional endoscopic sinus surgery (FESS).
Prabhat Choudhary +5 more
doaj +1 more source