Results 121 to 130 of about 1,285,314 (289)
Cancer Science, EarlyView.Schematic illustration of the mechanisms by which the natural quassinoid brusatol induces apoptosis in myeloid leukemias and enhances venetoclax efficacy via p53‐dependent apoptosis and mitochondrial dysfunction. ABSTRACT While venetoclax‐based combinations have shown promising results in acute myeloid leukemia (AML), the remission duration is ...
Shin‐ichiro Kawaguchi +11 more
wiley +1 more source
Cell Proliferation, EarlyView.We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang +12 more
wiley +1 more source
Floating, Official Dollarization, and Macroeconomic Volatility:An Analysis for the Chilean Economy [PDF]
This paper contrasts the volatility of the main macroeconomic variables of a small open economy in two environments: an official dollarization (OD) scheme and a flexible exchange regime (FER).
Roberto Duncan
core
The FEBS Journal, EarlyView.Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan +8 more
wiley +1 more source
The FEBS Journal, EarlyView.Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
wiley +1 more source
International Journal of Cosmetic Science, EarlyView.Photo grading of dynamic lines in the dynamic line repeatability validation study. Abstract Objective This study aimed to develop and validate a novel, integrated dynamic wrinkle assessment system based on standardized, real‐time and multi‐angle facial images and video recordings, and to explore its potential application in evaluating the anti‐wrinkle ...
Xingzuo Liu +6 more
wiley +1 more source
IEEE AccessThis article presents a model-based optimization method for grasping various known objects with a two-finger underactuated Fin-Ray soft gripper to ensure optimal grasping pose of an object in a gripper frame by maximizing the contact score, a grasp ...
Dario Stuhne, Goran Vasiljevic
doaj +1 more source
THESEUS1 is a component of the receptor complex for establishing polytubey block in Arabidopsis
Journal of Integrative Plant Biology, EarlyView.THESEUS1 (THE1) is a component of the CrRLK1L‐RALF signaling complex specifically responsible for establishing the polytubey block at the Arabidopsis septum. Genetic and biochemical analyses demonstrate that THE1, together with FERONIA, ANJ and HERK1, forms a receptor complex that senses pollen tube‐derived RALF peptides, thereby establishing a barrier
Qiyun Li +5 more
wiley +1 more source