Results 61 to 70 of about 88,565 (287)

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

The energy-converting hydrogenase Ech2 is important for the growth of the thermophilic acetogen Thermoanaerobacter kivui on ferredoxin-dependent substrates

Microbiology Spectrum
Thermoanaerobacter kivui is the thermophilic acetogenic bacterium with the highest temperature optimum (66°C) and with high growth rates on hydrogen (H2) plus carbon dioxide (CO2).
Christoph Baum, Benjamin Zeldes, Anja Poehlein, Rolf Daniel, Volker Müller, Mirko Basen   +5 more
doaj   +1 more source

An Abundant and Diverse New Family of Electron Bifurcating Enzymes With a Non-canonical Catalytic Mechanism

Frontiers in Microbiology, 2022
Microorganisms utilize electron bifurcating enzymes in metabolic pathways to carry out thermodynamically unfavorable reactions. Bifurcating FeFe-hydrogenases (HydABC) reversibly oxidize NADH (E′∼−280 mV, under physiological conditions) and reduce protons
Gerrit J. Schut, Dominik K. Haja, Xiang Feng, Farris L. Poole, Huilin Li, Michael W. W. Adams   +5 more
doaj   +1 more source

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme

Advanced Science, EarlyView.
The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun, Chao Dou, Weizhu Yan, Pengpeng Chen, Lu Zhang, Dan Zhou, Yanhui Zheng, Zhaolin Long, Shoujie Li, Xiaoqing Xu, Qiuxia Huang, Xiaofeng Zhu, Wei Cheng   +12 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Functional Characterization of the Eukaryotic Cysteine Desulfurase Nfs1p from Saccharomyces cerevisiae [PDF]

, 2004
Previous studies have indicated that the essential protein Nfs1 performs a crucial role in cellular iron-sulfur (Fe/S) protein maturation. The protein is located predominantly in mitochondria, yet low amounts are present in cytosol and nucleus.
Balk, Balk, Cupp-Vickery, Diekert, Dutkiewicz, Floss, Frazzon, Frazzon, Garland, Gerber, Gerber, Gietz, Gyula Kispal, Harlow, Hoff, Janneke Balk, Jaschkowitz, Jens T. Kaiser, Kaiser, Kambampati, Kambampati, Katalin Sipos, Kaut, Kim, Kispal, Knight, Knight, Knox, Kolman, Land, Lange, Lange, Lauhon, Leibrecht, Leipuviene, Li, Lill, Matthies, Meyer, Mihara, Mühlenhoff, Mühlenhoff, Mühlenhoff, Nachin, Nadine Richhardt, Nakai, Nakai, Nett, Nilsson, Outten, Papenbrock, Pierrel, Roland Lill, Roy, Sambrook, Schilke, Schwartz, Sherman, Silberg, Sipos, Skovran, Stein, Strain, Takahashi, Tong, Tong, Ulrich Mühlenhoff, Ungermann, Voisine, Wang, Yuvaniyama, Zheng, Zheng, Zheng   +73 more
core   +3 more sources

CO2-Induced Transcriptional Reorganization: Molecular Basis of Capnophillic Lactic Fermentation in Thermotoga neapolitana [PDF]

, 2020
Capnophilic lactic fermentation (CLF) is a novel anaplerotic pathway able to convert sugars to lactic acid (LA) and hydrogen using CO2 as carbon enhancer in the hyperthermophilic bacterium Thermotoga neapolitana.
Dipasquale, Laura, d’Ippolito, Giuliana, ESERCIZIO, NUNZIA, Fontana, Angelo, LANDI, SIMONE, Lanzilli, Mariamichella, Pradhan, Nirakar, VASTANO, MARCO   +7 more
core   +2 more sources

Mechanisms of Direct Electron Transfer Governed by Redox‐Active Conductive Carrier with Superior Wettability in Anaerobic Biofilms

Advanced Science, EarlyView.
A redox‐active conductive carrier of tannic acid‐modified iron‐biochar with superior wettability is demonstrated to regulate direct electron transfer at the anaerobic biofilm‐carrier interface by enhancing the cytochrome c‐mediated pathway. For the first time, integrated evidence from spectroscopy, electrochemical analyses, and metatranscriptomics ...
Junli Tian, Xiaoyuan Zhang, Lulu Xing, Bin Ji, Jinfeng Lu, Yu Liu   +5 more
wiley   +1 more source

Adrenodoxin—A versatile ferredoxin [PDF]

IUBMB Life, 2012
AbstractMammalian adrenodoxin (Adx) has been known for many years as an essential electron mediator in mitochondrial cytochrome P450 systems. Because of its ability to support several cytochrome P450 enzymes, it is involved not only in adrenal steroid hormone biosynthesis but also in vitamin D and bile acid metabolism.
Kerstin Maria, Ewen, Michael, Ringle, Rita, Bernhardt   +2 more
openaire   +2 more sources

Crystal structure of pectocin M1 reveals diverse conformations and interactions during its initial step via the ferredoxin uptake system

FEBS Open Bio
Pectocin M1 (PM1), the bacteriocin from phytopathogenic Pectobacterium carotovorum which causes soft rot disease, has a unique ferredoxin domain that allows it to use FusA of the plant ferredoxin uptake system.
Nawee Jantarit, Hideaki Tanaka, Yuxi Lin, Young‐Ho Lee, Genji Kurisu   +4 more
doaj   +1 more source