Activity of NAD(P)H-Oxidoreductases in Ovarian Cancer [PDF]
BiomedicinesReactive oxygen species (ROS) play an important and controversial role in carcinogenesis. Microsomal redox chains containing NADH- and NADPH-dependent oxidoreductases are among the main sites of intracellular ROS synthesis, but their role in the ...
Maria V. Fedorova +3 more
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The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis
Molecular & Cellular Oncology, 2021 Our recent study showed that two oxidoreductases – NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) – transfer electrons to oxygen to generate hydrogen peroxide (H2O2).
Youwei Ai, Bo Yan, Xiaodong Wang
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Copper oxide-based cathode for direct NADPH regeneration
Scientific Reports, 2021 Nearly a fourth of all enzymatic activities is attributable to oxidoreductases, and the redox reactions supported by this vast catalytic repertoire sustain cellular metabolism.
J. T. Kadowaki +4 more
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Adaptive evolution of electron transfer pathways in Thermoanaerobacterium saccharolyticum [PDF]
Journal of BacteriologyThermoanaerobacterium saccharolyticum is an anaerobic, thermophilic bacterium that has been proposed for use in consolidated bioprocessing in coculture with cellulolytic bacteria such as Clostridium thermocellum for ethanol production. Although the mixed
João H. T. M. Fabri +5 more
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The X-Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two-Component Flavin-Dependent Tryptophan Halogenase. [PDF]
ProteinsABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Ma Z, Rady EW, de Silva AJ, Bellizzi JJ.
europepmc +2 more sources
Assessing POR and CYB5R1 oxidoreductase-mediated oxidative rupture of PUFA in liposomes
STAR Protocols, 2021 Summary: Lipid peroxidation of polyunsaturated fatty acid (PUFA) phospholipids induces necrotic cell death through compromised cell membrane integrity during ferroptosis.
Bo Yan +3 more
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Research, 2021 Solar-driven photocatalytic regeneration of cofactors, including reduced nicotinamide adenine dinucleotide (NADH), reduced nicotinamide adenine dinucleotide phosphate (NADPH), and reduced flavin adenine dinucleotide (FADH2), could ensure the sustainable ...
Yuqing Cheng +7 more
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Characterization of NADH Oxidase/NADPH Polysulfide Oxidoreductase and Its Unexpected Participation in Oxygen Sensitivity in an Anaerobic Hyperthermophilic Archaeon [PDF]
Journal of Bacteriology, 2010 ABSTRACT Many genomes of anaerobic hyperthermophiles encode multiple homologs of NAD(P)H oxidase that are thought to function in response to oxidative stress. We investigated one of the seven NAD(P)H oxidase homologs (TK1481) in the sulfur-reducing hyperthermophilic archaeon Thermococcus kodakarensis ...
Satoshi Nakamura +5 more
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Identification of oxidoreductases from the petroleum Bacillus safensis strain
Biotechnology Reports, 2015 A gram-positive bacterium, denominated CFA-06, was isolated from Brazilian petroleum in the Campos Basin and is responsible for the degradation of aromatic compounds and petroleum aromatic fractions.
Francine S.A. da Fonseca +12 more
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A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis
Bioscience Reports, 2014 Methanothermobacter marburgensis is a strictly anaerobic, thermophilic methanogenic archaeon that uses methanogenesis to convert H2 and CO2 to energy. M.
Eva Ullmann +5 more
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