Results 11 to 20 of about 21,864 (146)

The two alternative NADH:quinone oxidoreductases from Staphylococcus aureus: two players with different molecular and cellular roles

Microbiology Spectrum
Staphylococcus aureus is an opportunistic pathogen that has emerged as a major public health threat due to the increased incidence of its drug resistance. S.
Filipa V. Sena, Filipe M. Sousa, Ana R. Pereira, Teresa Catarino, Eurico J. Cabrita, Mariana G. Pinho, Francisco R. Pinto, Manuela M. Pereira   +7 more
doaj   +2 more sources

The Ability of New Sugar-Modified Derivatives of Antitumor Anthracycline, Daunorubicin, to Stimulate NAD(P)H Oxidation in Different Cellular Oxidoreductase Systems: NADH Dehydrogenase, NADPH Cytochrome P450 Reductase, and Xanthine Oxidase

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2004
Numerous data indicate that cellular oxidoreductases may be responsible for the cardiotoxic effects of antitumor anthracycline drugs as a consequence of the mediation by these agents of one-electron transfer from reduced nucleotides to atmospheric oxygen.
Jolanta, Pawłowska, Waldemar, Priebe, Mark J I, Paine, C Roland, Wolf, Edward, Borowski, Jolanta, Tarasiuk   +5 more
openaire   +3 more sources

Pituitary 5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductases. Subcellular location and properties of NADH- and NADPH-linked activities.

Journal of Biological Chemistry, 1980
J E, Krause, H J, Karavolas
openaire   +3 more sources

Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1.

Molecules and Cells, 2020
Ferroptosis is a form of necrotic cell death caused by iron-dependent peroxidation of polyunsaturated phospholipids on cell membranes and is actively suppressed by the cellular antioxidant systems.
Bo Yan, Youwei Ai, Qi Sun, Yan Ma, Yang Cao, Jiawen Wang, Zhiyuan Zhang, Xiaodong Wang   +7 more
semanticscholar   +1 more source

Dihydrogen‐Driven NADPH Recycling in Imine Reduction and P450‐Catalyzed Oxidations Mediated by an Engineered O2‐Tolerant Hydrogenase

ChemCatChem, 2020
The O2‐tolerant NAD+‐reducing hydrogenase (SH) from Ralstonia eutropha (Cupriavidus necator) has already been applied in vitro and in vivo for H2‐driven NADH recycling in coupled enzymatic reactions with various NADH‐dependent oxidoreductases.
Janina Preissler, H. Reeve, Tianze Zhu, J. Nicholson, Kouji Urata, L. Lauterbach, L. Wong, K. Vincent, O. Lenz   +8 more
semanticscholar   +1 more source

Oxidoreductases generate hydrogen peroxide that drives iron-dependent lipid peroxidation during ferroptosis

bioRxiv, 2020
The inhibition of antioxidant systems of glutathione peroxidase 4 (GPX4) or ferroptosis suppressor protein 1 (FSP1) causes iron-dependent peroxidation of polyunsaturated phospholipids that leads to cell death, a process known as ferroptosis.
Bo Yan, Youwei Ai, Ze Zhang, Qi Sun, Yan Ma, Zhiyuan Zhang, Xiaodong Wang   +6 more
semanticscholar   +1 more source

Two functionally distinct NADP+-dependent ferredoxin oxidoreductases maintain the primary redox balance of Pyrococcus furiosus

Journal of Biological Chemistry, 2017
Electron bifurcation has recently gained acceptance as the third mechanism of energy conservation in which energy is conserved through the coupling of exergonic and endergonic reactions.
Diep Nguyen, G. Schut, O. Zadvornyy, Monika Tokmina-Lukaszewska, Saroj Poudel, G. Lipscomb, L. Adams, Jessica T. Dinsmore, W. Nixon, E. Boyd, B. Bothner, J. Peters, M. Adams   +12 more
semanticscholar   +1 more source

Ca2+-binding and Ca2+-independent Respiratory NADH and NADPH Dehydrogenases of Arabidopsis thaliana*

Journal of Biological Chemistry, 2007
Type II NAD(P)H:quinone oxidoreductases are single polypeptide proteins widespread in the living world. They bypass the first site of respiratory energy conservation, constituted by the type I NADH dehydrogenases.
D. Geisler, Christian Broselid, L. Hederstedt, A. Rasmusson   +3 more
semanticscholar   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source