Results 51 to 60 of about 3,197 (196)

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Light‐Driven Butyrate Production by a Probiotic Clostridium tyrobutyricum Enabled by a Cell‐Semiconductor Hybrid Interface

Food Chemistry International, EarlyView.
This schematic illustrates a light‐driven biohybrid system where CdS nanoparticles, mineralized on the probiotic Clostridium tyrobutyricum, inject photoelectrons to elevate intracellular NADH. This boosts the flux through key NADH‐dependent enzymes (GapA, Hbd, and Bcd), reprogramming metabolism to enhance butyrate yield by 33.2% and selectivity to 95.7%
Qianru Zhao, Zhihan Yang, Bowen Shen, Ling Jiang   +3 more
wiley   +1 more source

A Personal Perspective on Metalloprotein Structure and the Future of Macromolecular X‐Ray Crystallography

Journal of the Chinese Chemical Society, EarlyView.
While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley   +1 more source

Mitochondria as a Possible Place for Initial Stages of Steroid Biosynthesis in Plants [PDF]

Journal of Stress Physiology & Biochemistry, 2014
With the aim of thorough comparison of steroidogenic systems of plants and animals, transgenic plants of Solanaceae family expressing CYP11A1 cDNA encoding cytochrome P450SCC of mammalian mitochondria were further analysed.
Elena K. Shematorova, Ivan Yu. Slovokhotov, Marat R. Khaliluev, Irina N. Berdichevets, Ekaterina N. Baranova, Olga G. Babak, Dmitry G. Shpakovski, Svetlana G. Spivak, George V. Shpakovski   +8 more
doaj  

Organizational and Functional Principles of the Obligate Respiratory Chain Supercomplex

Journal of the Chinese Chemical Society, EarlyView.
In this review we deliver a comprehensive structural analysis of the actinobacterial respiratory chain supercomplex and discuss the principles underlying the assembly of its supramolecular architecture. ABSTRACT Proton translocating respiratory chain complexes assemble into supramolecular structures in their native cellular environment, yet the ...
Wei‐Chun Kao, Nick Hiatt, Carola Hunte
wiley   +1 more source

Cryo-EM map and functional electron transport studies of the HoxEFU subcomplex of the HOX [NiFe]-hydrogenase from Synechocystis sp. PCC 6803

Cell Reports Physical Science
Summary: The HOX [NiFe]-hydrogenase of Synechocystis sp. PCC 6803 is composed of large (HoxH) and small (HoxY) subunits that catalyze H2 activation and HoxE, HoxF, and HoxU subunits that catalyze reactions with NAD(H), ferredoxins, or flavodoxin.
Michael E. Dawson, Effie C. Kisgeropoulos, Josephine N. Gruber, Samantha J. Ziegler, Vivek S. Bharadwaj, Peter J. Dahl, Matthew R. Blahut, Seth A. Wiley, Jacob H. Artz, Carolyn E. Lubner, David W. Mulder, Paul W. King   +11 more
doaj   +1 more source

Plant species are more important to bacterial community composition than seeding ratio in a pea‐canola intercropping system

PLANTS, PEOPLE, PLANET, EarlyView.
Demand for agricultural land has increased due to rising demand for food, potentially leading to expansion into previously untouched habitats, which threatens refugia of native plants. We aimed to provide insight into how variation in seeding ratio may impact soil bacterial communities in a pea‐canola intercropping system, potentially altering crop ...
Janice M. Parks, Braeden J. Stiffler, Maren L. Friesen   +2 more
wiley   +1 more source

Plant responses to iron nutrition with emphasis on the underutilized crop tef (Eragrostis tef): A review

PLANTS, PEOPLE, PLANET, EarlyView.
Iron (Fe) deficiency limits the physical health, cognitive development, and economic output of billions of people globally, especially children and productive‐age women. Tef is an underutilized and stress‐resilient crop, which is becoming popular for its grains containing high bioavailable Fe and has the potential to mitigate Fe deficiency.
Muhammad Numan, David Remington, Ayalew Ligaba‐Osena   +2 more
wiley   +1 more source

Iron-Sulfur Clusters: A Core Hub in Insect Energy, Reproduction, and Molting

Insects
Iron-sulfur clusters are a class of functionally diverse protein cofactors. In recent years, significant progress has been made in insect research on iron-sulfur clusters, revealing that they serve as a core molecular hub that integrate multiple ...
Xiao-Han Di, Shuo Liu, Duo Wang, Jing-Ze Liu   +3 more
doaj   +1 more source

Ferredoxin containing bacteriocins suggest a novel mechanism of iron uptake in Pectobacterium spp.

PLoS ONE, 2012
In order to kill competing strains of the same or closely related bacterial species, many bacteria produce potent narrow-spectrum protein antibiotics known as bacteriocins. Two sequenced strains of the phytopathogenic bacterium Pectobacterium carotovorum
Rhys Grinter, Joel Milner, Daniel Walker
doaj   +1 more source