Results 11 to 20 of about 286,555 (389)
Ferritin, cellular iron storage and regulation [PDF]
IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2017 Paolo Arosio, Leonardo Elia, Maura Poli
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NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy
Journal of Cell Biology, 2022 Ohshima et al. demonstrate that the iron-storage protein ferritin undergoes liquid–liquid phase separation, which is mediated by multivalent interactions with NCOA4.
T. Ohshima +4 more
semanticscholar +1 more source
The Role of Ferritin in Health and Disease: Recent Advances and Understandings
Metabolites, 2022 Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc.
N. Kotla +3 more
semanticscholar +1 more source
Ferritin – a multifaceted protein scaffold for biotherapeutics
Experimental and Molecular Medicine, 2022 The ferritin nanocage is an endogenous protein that exists in almost all mammals. Its hollow spherical structure that naturally stores iron ions has been diversely exploited by researchers in biotherapeutics.
Na-Kyeong Lee, Seongeon Cho, Insun Kim
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Therapeutic Advances in Respiratory Disease, 2020 Background: Patients critically ill with coronavirus disease-2019 (COVID-19) feature hyperinflammation, and the associated biomarkers may be beneficial for risk stratification. We aimed to investigate the association between several biomarkers, including
I. Huang +4 more
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Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis
Circulation Research, 2020 Supplemental Digital Content is available in the text. Rationale: Maintaining iron homeostasis is essential for proper cardiac function. Both iron deficiency and iron overload are associated with cardiomyopathy and heart failure via complex mechanisms ...
X. Fang +17 more
semanticscholar +1 more source
Chemistry and Biology of Ferritin
Metallomics, 2021 Iron is an essential element required by cells and has been described as a key player in ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming multimeric assemblies with crystalline iron cores.
M. Plays, S. Müller, R. Rodriguez
semanticscholar +1 more source
Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
Journal of clinical laboratory analysis (Print), 2020 The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients.
Linlin Cheng +6 more
semanticscholar +1 more source
ACS Central Science, 2021 The development of a safe and effective SARS-CoV-2 vaccine is a public health priority. We designed subunit vaccine candidates using self-assembling ferritin nanoparticles displaying one of two multimerized SARS-CoV-2 spikes: full-length ectodomain (S ...
Abigail E. Powell +9 more
semanticscholar +1 more source
British Journal of Cancer, 2020 AbstractElevated levels of serum ferritin (SF) are observed in several types of cancer; however, little is known on the association between ferritin and glioma, the most frequent type of human primary brain tumour. Here we report that GBM patients show significantly increased pre-surgical SF levels (i.e. ferritinaemia) within the SF reference range and
Jaksch-Bogensperger, Heidi +9 more
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