Results 101 to 110 of about 87,796 (384)
Advanced Science, EarlyView.Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen +14 more
wiley +1 more source
Ferritin Nanocages for Protein Delivery to Tumor Cells
Molecules, 2020 The delivery of therapeutic proteins is one of the greatest challenges in the treatment of human diseases. In this frame, ferritins occupy a very special place.
Federica Palombarini +4 more
doaj +1 more source
Ferritin structure from Mycobacterium tuberculosis: comparative study with homologues identifies extended C-terminus involved in ferroxidase activity. [PDF]
PLoS ONE, 2011 Ferritins are recognized as key players in the iron storage and detoxification processes. Iron acquisition in the case of pathogenic bacteria has long been established as an important virulence mechanism.
Garima Khare +5 more
doaj +1 more source
Natural supramolecular protein assemblies [PDF]
, 2016 Supramolecular protein assemblies are an emerging area within the chemical sciences, which combine the topological structures of the field of supramolecular chemistry and the state-of-the-art chemical biology approaches to unravel the formation and ...
Mecinović, Jasmin +3 more
core +2 more sources
Advanced Science, EarlyView.EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen +9 more
wiley +1 more source
Aqueous solution dispersement of carbon nanotubes [PDF]
, 2011 Carbon nanotubes (CNTs) are dispersed in an aqueous buffer solution consisting of at least 50 weight percent water and a remainder weight percent that includes a buffer material.
Choi, Sang H. +4 more
core +1 more source
JAMA, 2014 An elevated ferritin level was discovered during an anemia evaluation in a 46-year-old man with inflammatory arthritis. The patient reported pain in multiple joints for which he took indomethacin. He also consumed 2 alcoholic beverages daily. His mother had inflammatory arthritis and his sister had lupus.
Richard M. Green, Lisa B. VanWagner
openaire +3 more sources
Advanced Science, EarlyView.A nanomodulator (Ft‐E64/Hf@Lipo) is developed, combining radiosensitizer hafnium (Hf) and the cysteine protease inhibitor E64, which cooperatively reinvigorated the antigen presentation of TAMs. Ft‐E64/Hf@Lipo sensitized‐RT generated abundant tumor neoantigens, and then E64/antigens, along with the apoptotic tumor cells, trafficked to TAMs via ...
Xiu Zhao +9 more
wiley +1 more source
Machine Learning‐Enhanced Nanoparticle Design for Precision Cancer Drug Delivery
Advanced Science, EarlyView.Machine Learning (ML) is revolutionizing cancer nanomedicine by optimizing nanoparticle (NP) design and drug delivery. This review summarizes ML applications across all stages of NP drug delivery, along with a discussion of ongoing challenges and future directions.
Qingquan Wang +5 more
wiley +1 more source
Revista Cubana de Hematología, Inmunología y Hemoterapia, 2013 Introducción: la donación de sangre repetitiva y el sexo femenino potencian el desarrollo de deficiencia de hierro que provoca un suministro inadecuado de sangre y compromiso de la salud del donante.
Carmen Yulieth Mantilla-Gutiérrez +1 more
doaj