Heterologous Expression of Either Human or Soya Bean Ferritins in Budding Yeast Reveals Common Functions Protecting Against Oxidative Agents and Counteracting Double-Strand Break Accumulation [PDF]
BiomoleculesFerritins are globular proteins that, upon self-assembly in nanocages, are capable of bio-safely storing huge concentrations of bioavailable iron. They are present in most cell types and organisms; one of the exceptions is yeast.
Nuria Pujol Carrión +1 more
doaj +3 more sources
Iron Oxidation and Core Formation in Recombinant Heteropolymeric Human Ferritins [PDF]
Biochemistry, 2017 In animals, the iron storage and detoxification protein, ferritin, is composed of two functionally and genetically distinct subunit types, H (heavy) and L (light), which co-assemble in various ratios with tissue specific distributions to form shell ...
Poli, Maura +13 more
core +2 more sources
A natural biogenic nanozyme for scavenging superoxide radicals [PDF]
Nature CommunicationsBiominerals, the inorganic minerals of organisms, are known mainly for their physical property-related functions in modern living organisms. Our recent discovery of the enzyme-like activities of nanomaterials, coined as nanozyme, inspires the hypothesis ...
Long Ma +9 more
doaj +2 more sources
Iron core mineralisation in prokaryotic ferritins
Biochimica et Biophysica Acta, 2010 The prokaryotic ferritins exhibit a wide variation in mechanisms of iron core mineralisation. The basis of these differences lies, at least in part, in structural differences at and around the catalytic centre.
Mauk, A. Grant +5 more
core +2 more sources
Ferritins control interaction between iron homeostasis and oxidative stress in Arabidopsis.
The Plant Journal, 2009 International audienceFerritin protein nanocages are the main iron store in mammals. They have been predicted to fulfil the same function in plants but direct evidence was lacking. To address this, a loss-of-function approach was developed in Arabidopsis.
Touraine, Brigitte +5 more
core +2 more sources
Probing bulky ligand entry in engineered archaeal ferritins
Biochimica et Biophysica Acta - General Subjects, 2016 Background: A set of engineered ferritin mutants from Archaeoglobus fulgidus (Af-Ft) and Pyrococcus furiosus (Pf-Ft) bearing cysteine thiols in selected topological positions inside or outside the ferritin shell have been obtained.
BENNI, IRENE +8 more
core +2 more sources
Ferritins: A family of molecules for iron storage, antioxidation and more
Biochimica et Biophysica Acta, 2009 Ferritins are characterized by highly conserved three-dimensional structures similar to spherical shells, designed to accommodate large amounts of iron in a safe, soluble and bioavailable form.
AROSIO, Paolo +2 more
core +2 more sources
Iron reduction via periodic calibrated phlebotomy to target ferritin lowers cancer incidence and mortality in patients with peripheral artery disease: further insights from the FeAST trial [PDF]
Frontiers in OncologyPaul Pisarik
doaj +2 more sources
Biochemistry, 2022 Ferritins are highly conserved supramolecular protein nanostructures that play a key role in iron homeostasis. Thousands of iron atoms can be stored inside their hollow cavity as a hydrated ferric oxyhydroxide mineral.
Aliaksandra A Reutovich +8 more
semanticscholar +1 more source
Association between serum ferritin levels and colorectal cancer risk in Korea [PDF]
The Korean Journal of Internal Medicine, 2022 Background/Aims The concentration of serum ferritin, a storage form of iron, may be associated with carcinogenesis in various cancers. There are only limited studies on the relationship between serum ferritin levels and colorectal cancer (CRC) risk ...
Hyunho Kim +3 more
doaj +1 more source