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Ferroportin is a monomer in vivo in mice
Blood Cells, Molecules, and Diseases, 2006Ferroportin (FPN) is the main iron export protein in mammals. The actual structure of FPN in vivo and the pathogenesis of ferroportin-related disease are unknown. We aimed at studying the structure and biochemical properties of FPN in mouse tissues that are key for iron homeostasis during various iron manipulations in vivo.
PIGNATTI, Elisa +5 more
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Biology of the iron efflux transporter, ferroportin
2021Iron, the most common metal in the earth, is also an essential component for almost all living organisms. While these organisms require iron for many biological processes, too much or too little iron itself poses many issues; this is most easily recognized in human beings.
Rishi, Gautam, Subramaniam, V. Nathan
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Clinical Journal of Gastroenterology, 2014
Reticuloendothelial iron overload is associated with secondary hemochromatosis including repeated transfusions and iron over-supplementation. Ferroportin disease B is a severe subtype of hereditary iron overload syndrome with an activated reticuloendothelial system.
Tetsuji, Yamashita +11 more
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Reticuloendothelial iron overload is associated with secondary hemochromatosis including repeated transfusions and iron over-supplementation. Ferroportin disease B is a severe subtype of hereditary iron overload syndrome with an activated reticuloendothelial system.
Tetsuji, Yamashita +11 more
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Of mice and iron: ferroportin disease
Blood, 2007[Comment on Zohn et al, page 4174][1]In this issue of Blood , Zohn and colleagues describe a novel mouse mutant that bears a striking similarity to the most enigmatic of human hemochromatosis disorders, ferroportin disease.
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Iron transporter ferroportin FPN1
2003Iron is a major component of the Earth’s crust, but its own chemistry greatly limits its utilization and also sets the basis for its toxicity. The capacity of readily exchanging electrons in aerobic conditions makes iron essential for fundamental cell functions, such as DNA synthesis, transport of oxygen and electrons, and cell respiration.
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Proceedings of the National Academy of Sciences of the United States of America, 2022
Eun-Kyung Choi +2 more
exaly
Eun-Kyung Choi +2 more
exaly
Ferroportin disease: A novel SLC40A1 mutation
Digestive and Liver Disease, 2020Ravasi G. +4 more
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A simple clinical score to promote and enhance ferroportin disease screening
Journal of Hepatology, 2022Amandine Landemaine +2 more
exaly