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Erythroferrone-Driven Regulation of Hepcidin and Iron Levels in Polytransfused Sickle Cell Anaemia Patients: A Prospective Study. [PDF]
Biomed Res IntAppiah SK +20 more
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Cell Metabolism, 2015 Maintaining physiologic iron concentrations in tissues is critical for metabolism and host defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes, and iron mobilization from storage in macrophages and hepatocytes constitute the major iron flows into plasma for distribution to tissues, predominantly for erythropoiesis ...
Hal Drakesmith +2 more
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Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination [PDF]
Cell Metabolism, 2012 Ferroportin exports iron into plasma from absorptive enterocytes, erythrophagocytosing macrophages, and hepatic stores. The hormone hepcidin controls cellular iron export and plasma iron concentrations by binding to ferroportin and causing its internalization and degradation. We explored the mechanism of hepcidin-induced endocytosis of ferroportin, the
Priscilla Sugianto +2 more
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Blood Cells, Molecules, and Diseases, 2004 A new inherited disorder of iron metabolism, hereafter called "the ferroportin disease," is increasingly recognized worldwide. The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not ...
Antonello Pietrangelo
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Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT [PDF]
Cell Metabolism, 2012 Ferroportin is the primary means of cellular iron efflux and a key component of iron metabolism. Hepcidin regulates Fpn activity by inducing its internalization and degradation. The mechanism of internalization is reported to require JAK2 activation, phosphorylation of Fpn tyrosine residues 302 and 303, and initiation of transcription through STAT3 ...
Aaron G Winters +2 more
exaly +3 more sources
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Ferroportin-inhibitor salt: patent evaluation WO2018192973
Expert Opinion on Therapeutic Patents, 2021Iron is a crucial element necessary for blood formation in the body and its normal growth. However, irregular metabolism of iron due to absence of an elimination mechanism may deposit excess iron in the organs (iron overload) leading to metabolic disorders.
Snehal Kadam +3 more
openaire +2 more sources
Ferroportin-mediated iron transport: Expression and regulation
Biochimica Et Biophysica Acta - Molecular Cell Research, 2012 The distinguishing feature between iron homeostasis in single versus multicellular organisms is the need for multicellular organisms to transfer iron from sites of absorption to sites of utilization and storage. Ferroportin is the only known iron exporter and ferroportin plays an essential role in the export of iron from cells to blood. Ferroportin can
Diane M Ward
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Functional consequences of ferroportin 1 mutations
Blood Cells, Molecules, and Diseases, 2005The cellular iron exporter ferroportin 1 is expressed in both the duodenum and in cells of the mononuclear phagocyte system. Expression of ferroportin 1 protein on the cell surface is regulated by the interaction of ferroportin 1 with hepcidin. Hepcidin treatment of cells results in internalization and lysosomal degradation of cell surface ferroportin ...
Xiao-Bing, Liu +2 more
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