Results 201 to 210 of about 17,123 (223)
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Expression of ferroportin in hemochromatosis liver
Blood Cells, Molecules, and Diseases, 2003Iron-regulated transporter protein 1 (IREG1 or ferroportin 1) is a transmembrane iron transporter that has been described in macrophages and hepatocytes. Ferroportin mutations have been described to result in hepatic iron overload in human pedigrees.
Paul C, Adams +3 more
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Gastroenterology, 2011
Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin saturation. In contrast, hepatocellular iron storage, hyperferritinemia, and increased saturation of transferrin are a distinct clinical presentation of ferroportin iron overload that results from
Roman, Mayr +11 more
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Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin saturation. In contrast, hepatocellular iron storage, hyperferritinemia, and increased saturation of transferrin are a distinct clinical presentation of ferroportin iron overload that results from
Roman, Mayr +11 more
openaire +2 more sources
Structural insights into ferroportin mediated iron transport
Biochemical Society Transactions, 2023Iron is a vital trace element for almost all organisms, and maintaining iron homeostasis is critical for human health. In mammals, the only known gatekeeper between intestinally absorbed iron and circulatory blood plasma is the membrane transporter ferroportin (Fpn).
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Biology of the iron efflux transporter, ferroportin
2021Iron, the most common metal in the earth, is also an essential component for almost all living organisms. While these organisms require iron for many biological processes, too much or too little iron itself poses many issues; this is most easily recognized in human beings.
Rishi, Gautam, Subramaniam, V. Nathan
openaire +3 more sources
Archives of Biochemistry and Biophysics, 2011
Iron is an essential element of hemoglobin, and efficient iron recycling from senescent erythrocytes by splenic macrophages is required for erythrocyte hemoglobin synthesis during erythropoiesis. Ferroportin 1 (Fpn1) is the sole iron exporter in mammals, and it also regulates iron reutilization.
Tomonori Hosoya +2 more
exaly +3 more sources
Iron is an essential element of hemoglobin, and efficient iron recycling from senescent erythrocytes by splenic macrophages is required for erythrocyte hemoglobin synthesis during erythropoiesis. Ferroportin 1 (Fpn1) is the sole iron exporter in mammals, and it also regulates iron reutilization.
Tomonori Hosoya +2 more
exaly +3 more sources
Iron transporter ferroportin FPN1
2003Iron is a major component of the Earth’s crust, but its own chemistry greatly limits its utilization and also sets the basis for its toxicity. The capacity of readily exchanging electrons in aerobic conditions makes iron essential for fundamental cell functions, such as DNA synthesis, transport of oxygen and electrons, and cell respiration.
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Ferroportin disease: A novel SLC40A1 mutation
Digestive and Liver Disease, 2020Ravasi G. +4 more
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Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
Nature, 2020Christian Bache Billesbølle +2 more
exaly