Results 141 to 150 of about 72,927 (343)

A guide to ferroptosis in cancer

Molecular Oncology
Ferroptosis is a newly identified iron‐dependent type of regulated cell death that can also be regarded as death caused by the specific collapse of the lipid antioxidant defence machinery. Ferroptosis has gained increasing attention as a potential therapeutic strategy for therapy‐resistant cancer types.
Fatma Isil Yapici, Christina M. Bebber, Silvia von Karstedt   +2 more
openaire   +3 more sources

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Antioxidant systems as modulators of ferroptosis: focus on transcription factors [PDF]

Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis and is related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, and ...
Carolina Punziano, Elena Cesaro, Michela Grosso, Raffaella Faraonio, Silvia Trombetti   +4 more
core   +1 more source

Ruthenium Single‐Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron–Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic‐Amplified Ferroptosis

Advanced Science, EarlyView.
An atomic‐level engineered ruthenium single‐atom nanozyme is fabricated that features sufficient oxygen vacancies and electron and hole separation efficiency, which enhances response to the sono‐suppressive tumor microenvironment and induces tumor ferroptosis.
Yang Zhu, Dengliang Wang, Chengzhong Du, Tiantian Wu, Penghui Wei, Hongjia Zheng, Guanting Li, ShunZhe Zheng, Lichao Su, Lingjun Yan, Yongrui Hu, Huimin Wang, Lisen Lin, Chenyu Ding, Xiaoyuan Chen   +14 more
wiley   +1 more source

HIVEP3 cooperates with ferroptosis gene signatures to confer adverse prognosis in acute myeloid leukemia

Cancer Medicine, Volume 11, Issue 24, Page 5050-5065, December 2022., 2022
The aberrant expression pattern and prognostic implications of HIVEP3 in AML were explored and validated based on versatile bioinformatics tools. A LASSO model which combined HIVEP3 with ferroptosis regulators was created to predict the prognosis for AML patients.
Xiaoning Zhang, Xiaoyu Zhang, Kuo Liu, Wenwen Li, Jiazheng Wang, Peng Liu, Wanshan Ma   +6 more
wiley   +1 more source

Camouflaged Nanozymes with Oxidation‐Promoting Activities Triggering Ferroptosis for Radio‐Immunotherapy

Advanced Science, EarlyView.
This study develops a cancer cell membrane‐coated nanozyme that enhances radiotherapy and reshapes the immunosuppressive microenvironment by generating oxygen in situ and disrupting tumor antioxidant defenses, offering a new strategy for breast cancer radioimmunotherapy.
Kun Qiao, Yongbiao Huang, Shipeng Ning, Meng Lyu, Jieqiong Xie, Shiyuan Zhang, Xiuxin Lu, Yuan Yu, Wei Jiang, Bo Liu, Kelong Fan, Tong Liu   +11 more
wiley   +1 more source

Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease

Journal of Mazandaran University of Medical Sciences, 2021
Ferroptosis is a new type of programmed cell death that plays an important role in various cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure.
Soghra Farzipour, Fereshteh Talebpour Amiri, Maryam Alvandi, Zahra Shaghaghi, Amirhossein Yazdi   +4 more
doaj  

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis [PDF]

, 2016
Xinlei Yu, Yun Chau Long
openalex   +1 more source

Oncogenic KRAS renders cells resistant to ferroptosis by upregulating FSP1 [PDF]

, 2023
RAS genes are the most frequently mutated oncogenes across human cancers and mutations in RAS lead to malignant transformation, tumor initiation and tumor maintenance. Mutant KRAS is the most common and most aggressive isoform and occurs in the deadliest
Müller, Fabienne
core  

Study of the mechanism of electroacupuncture regulating ferroptosis, inhibiting bladder neck fibrosis, and improving bladder urination function after suprasacral spinal cord injury using proteomics [PDF]

arXiv
Purpose The aim of this study was to explore whether electroacupuncture regulates phenotypic transformation of smooth muscle cells by inhibiting ferroptosis and inhibiting fibrosis, thereby improving bladder urination function after suprasacral spinal cord injury (SSCI). Methods The experiment was divided into sham, model, and electroacupuncture group.
arxiv