Results 141 to 150 of about 115,871 (339)

A guide to ferroptosis in cancer

Molecular Oncology
Ferroptosis is a newly identified iron‐dependent type of regulated cell death that can also be regarded as death caused by the specific collapse of the lipid antioxidant defence machinery. Ferroptosis has gained increasing attention as a potential therapeutic strategy for therapy‐resistant cancer types.
Fatma Isil Yapici, Christina M. Bebber, Silvia von Karstedt   +2 more
openaire   +3 more sources

Molecular crosstalk between apoptosis, necroptosis, and survival signaling [PDF]

, 2015
Our current knowledge of the molecular mechanisms regulating the signaling pathways leading to cell survival, cell death, and inflammation has shed light on the tight mutual interplays between these processes.
Bertrand, Mathieu, Kaiser, William J, Vanden Berghe, Tom, Vandenabeele, Peter   +3 more
core   +2 more sources

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis [PDF]

, 2016
Xinlei Yu, Yun Chau Long
openalex   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

Advanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding, Fan Tong, Mingqiu Liu, Pin Yang, Jing Zeng, Yinghua Wei, Chunlin Li, Dong Li, Cheng Chang, Yangjun Zhang, Shaoqiong Yi, Fan Hu, Wenjie Shu, Lingqiang Zhang, Chun‐Ping Cui   +14 more
wiley   +1 more source

Ferroptosis: a new hunter of hepatocellular carcinoma

Cell Death Discovery
Ferroptosis is an iron ion-dependent, regulatory cell death modality driven by intracellular lipid peroxidation that plays a key role in the development of HCC.
Yulang Jiang, Yongxin Yu, Ziyang Pan, Christian Glandorff, Mingyu Sun   +4 more
doaj   +1 more source

A review on ferroptosis and photodynamic therapy synergism: Enhancing anticancer treatment

Heliyon
Ferroptosis is an iron-dependent programmed cell death modality, which has showed great potential in anticancer treatment. Photodynamic therapy (PDT) is widely used in clinic as an anticancer therapy.
Qihang Chang, Peiru Wang, Qingyu Zeng, Xiuli Wang   +3 more
doaj   +1 more source

The α6β4 integrin promotes resistance to ferroptosis [PDF]

, 2017
Caitlin W. Brown, John J. Amante, Hira Lal Goel, Arthur M. Mercurio   +3 more
openalex   +1 more source

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source