Results 241 to 250 of about 109,999 (379)

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis [PDF]

, 2020
Minyi Xu, Jin Tao, Yidong Yang, Siwei Tan, Huiling Liu, Jie Jiang, Fengping Zheng, Bin Wu   +7 more
openalex   +1 more source

Bioinformatic Analysis and Molecular Docking Identify Isorhamnetin Is a Candidate Compound in the Treatment of Pulmonary Artery Hypertension. [PDF]

Anatol J Cardiol
Shao C, Xia W, Liu Y.
europepmc   +1 more source

Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury

, 2019
L. Joseph Su, Xiaofang Jiang, Cheng‐Ta Yang, Jiahao Zhang, Bo Chen, Yiming Li, Shijie Yao, Qin Xie, Candelaria Gómez-Manzano, Raghavan Murugan, Zhiyong Peng   +10 more
openalex   +1 more source

DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis [PDF]

, 2019
Zeyad D. Nassar, Chui Y. Mah, Jonas Dehairs, Ingrid J.G. Burvenich, Swati Irani, Margaret M. Centenera, Raj K. Shrestha, Max Moldovan, Anthony S. Don, Andrew M. Scott, Lisa G. Horvath, David J. Lynn, Luke A. Selth, Andrew J. Hoy, Johannes V. Swinnen, Lisa M. Butler   +15 more
openalex   +1 more source

Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib [PDF]

, 2020
Xiang Song, Xinzhao Wang, Zhaoyun Liu, Zhiyong Yu   +3 more
openalex   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

From mitochondrial dysregulation to ferroptosis: Exploring new strategies and challenges in radioimmunotherapy (Review). [PDF]

Int J Oncol
Wang T, Zhou X, Yin X, Zhang A, Fan Y, Chen K, Tao H, Tang Z, Zhang P, He X, Yin L.   +10 more
europepmc   +1 more source

ACS Chem Biol [PDF]

While opto-genetics has proven to have tremendous value in revealing the functions of the macromolecular machinery in cells, it is not amenable to exploration of small molecules such as phospholipids (PLs).

core  

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source