Results 31 to 40 of about 72,927 (343)
Induction and application of ferroptosis in cancer therapy
Cancer Cell International, 2022 At present, more than one cell death pathways have been found, one of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid peroxidation-driven regulated cell death pathway.
Qing Nie +4 more
doaj +1 more source
Chinese Medical Journal, 2023 Abstract Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-lipid peroxidation ...
Tianxin Lyu +4 more
openaire +3 more sources
DCcov: Repositioning of Drugs and Drug Combinations for SARS-CoV-2 Infected Lung through Constraint-Based Modelling [PDF]
, 2021 The 2019 coronavirus disease (COVID-19) became a worldwide pandemic with currently no effective antiviral drug except treatments for symptomatic therapy. Flux balance analysis is an efficient method to analyze metabolic networks. It allows optimizing for a metabolic function and thus e.g., predicting the growth rate of a specific cell or the production
arxiv +1 more source
Lipid metabolism in ferroptosis and ferroptosis-based cancer therapy
Frontiers in Oncology, 2022 Ferroptosis refers to iron-dependent, specialized, and regulated-necrosis mediated by lipid peroxidation, which is closely related to a variety of diseases, including cancer. Tumor cells undergo extensive changes in lipid metabolism, including lipid peroxidation and ferroptosis. Changes in lipid metabolism are critical for the regulation of ferroptosis
Yonghao Sun +4 more
openaire +3 more sources
Ferroptosis in Neurological Diseases [PDF]
Frontiers in Cellular Neuroscience, 2020 Ferroptosis is mechanism for non-apoptotic, iron-dependent, oxidative cell death that is characterized by glutathione consumption and lipid peroxides accumulation. Ferroptosis is crucially involved in neurological diseases, including neurodegeneration, stroke and neurotrauma.
Jia-Xin Ren +5 more
openaire +4 more sources
Opportunities and challenges related to ferroptosis in glioma and neuroblastoma
Frontiers in Oncology, 2023 A newly identified form of cell death known as ferroptosis is characterized by the peroxidation of lipids in response to iron. Rapid progress in research on ferroptosis in glioma and neuroblastoma has promoted the exploitation of ferroptosis in related ...
Huizhong Chi +13 more
doaj +1 more source
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. [PDF]
, 2019 Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-
A Arroyo +43 more
core +1 more source
Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia [PDF]
, 2023 Ferroptosis is a mode of cell death regulated by iron-dependent lipid peroxidation. Growing evidence suggests ferroptosis induction as a novel anti-cancer modality that could potentially overcome therapy resistance in cancers.
Akiyama, Hiroki +3 more
core +2 more sources
Ferroptosis and microbial pathogenesis
PLOS Pathogens, 2021 10.1371/journal.ppat.1009298 ; PLoS Pathogens ; 17 ; 3 ...
Qing Shen, Naweed I. Naqvi
openaire +6 more sources
Investigating the Mechanism of Arsenic-induced Ferroptosis in the Skin [PDF]
, 2023 Background: Ferroptosis, an oxidative and iron-dependent cell death, is a new type of regulated cell death. There are few studies on the mechanisms of ferroptosis in the skin and related diseases. Arsenic is shown to induce ferroptosis cell death.
Amiri-Dashatan, Nasrin +7 more
core +2 more sources