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Implication of ferroptosis in aging [PDF]
Cell Death Discovery, 2021 AbstractLife is indeed continuously going through the irreversible and inevitable process of aging. The rate of aging process depends on various factors and varies individually. These factors include various environmental stimuli including exposure to toxic chemicals, psychological stress whereas suffering with various illnesses specially the chronic ...
Maryam Mazhar +7 more
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Ferroptosis Patterns and Tumor Microenvironment Infiltration Characterization in Bladder Cancer
Frontiers in Cell and Developmental Biology, 2022 Background: Ferroptosis is a unique iron-dependent form of cell death and bladder cancer (BCa) is one of the top ten most common cancer types in the world.
Qi-Dong Xia +8 more
doaj +1 more source
A 3D cell death assay to quantitatively determine ferroptosis in spheroids [PDF]
, 2020 The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Declercq, Heidi +4 more
core +1 more source
Ferroptosis in life: To be or not to be
Biomedicine & Pharmacotherapy, 2023 Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria and aberrant accumulation of excessive iron as well as loss of the cysteine-glutathione-GPX4 axis.
Ling Xu +4 more
openaire +2 more sources
Ferroptosis: past, present and future
Cell Death and Disease, 2020 Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent ...
Jie Li +7 more
semanticscholar +1 more source
Scientific Reports, 2022 Ferroptosis genes have recently been reported to be involved in regulating the development of cancer, but their potential role in breast cancer (BRCA) is not fully understood.
Lianli Yin, Yinghua Tang
doaj +1 more source
Ferroptosis: molecular mechanisms and health implications
Cell Research, 2020 Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been mounting interest in the process and function of ferroptosis.
D. Tang, Xin Chen, R. Kang, G. Kroemer
semanticscholar +1 more source
Cross Talk Between Ferroptosis and Cerebral Ischemia
Frontiers in Neuroscience, 2020 Recently, ferroptosis has been revealed as a new form of regulated cell death. Distinct from apoptosis and necrosis, ferroptosis is evoked by iron-dependent lipid peroxidation.
Xu She, Bin Lan, Haomei Tian, Biao Tang
doaj +1 more source
Targeting ferroptosis in osteosarcoma
Journal of Bone Oncology, 2021 Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents, with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non-traditional mode of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid reactive oxygen species (ROS), is closely associated with a variety of cancers.
Benzheng Zhang +4 more
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Iron Metabolism in Ferroptosis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity in lipid peroxidation, ferroptosis is strictly ...
Chunhua Yu +5 more
openaire +4 more sources