Results 71 to 80 of about 72,927 (343)

Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway

Nano Convergence, 2021
Iron-based nanoparticles, which could elicit ferroptosis, is becoming a promising new way to inhibit tumor cell growth. Notably, ultrasmall iron oxide nanoparticles (USIONPs) have been found to upregulate the autophagy process in glioblastoma (GBM) cells.
Jian Wen, Hanren Chen, Zhongyu Ren, Peng Zhang, Jianjiao Chen, Shulian Jiang   +5 more
doaj   +1 more source

Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. [PDF]

, 2015
The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell ...
Aichler, M, Angeli, Jp, Buday, K, Conrad, M., Doll, S, Hoffard, N, Ingold, I, Roveri, Antonella, Tasdemir, A, Ursini, Fulvio, Walch, A, Wurst, W, Yefremova, E   +12 more
core   +1 more source

Ferroptosis and Necroptosis in the Kidney [PDF]

Cell Chemical Biology, 2020
In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI) and AKI to chronic kidney disease (CKD) progression has been revisited as our understanding of ferroptosis and necroptosis has emerged. A growing body of evidence, reviewed here, ascribes a central pathophysiological role for ferroptosis and necroptosis to AKI,
Andreas Linkermann, Julian Stumpf, Alexia Belavgeni, Christian Hugo, Claudia Meyer   +4 more
openaire   +3 more sources

Ferroptosis inhibitors: past, present and future

Frontiers in Pharmacology
Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective ...
Lei Zhang, Yi Lin Luo, Yang Xiang, Xin Yue Bai, Rong Rong Qiang, Xin Zhang, Yan Ling Yang, Xiao Long Liu   +7 more
doaj   +1 more source

Ferroptosis in Cancer Progression

Cells, 2023
Ferroptosis is a newly discovered iron-dependent form of regulated cell death driven by phospholipid peroxidation and associated with processes including iron overload, lipid peroxidation, and dysfunction of cellular antioxidant systems. Ferroptosis is found to be closely related to many diseases, including cancer at every stage. Epithelial–mesenchymal
Rongyu Zhang, Jinghong Chen, Saiyang Wang, Wenlong Zhang, Quan Zheng, Rong Cai   +5 more
openaire   +3 more sources

Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs [PDF]

, 2021
Ferroptosis is a newly identified form of regulated cell death that is associated with iron metabolism and oxidative stress. As a physiological mechanism, ferroptosis selectively removes cancer cells by regulating the expression of vital chemical ...
Gao, Ling, Liang, Xiao, Ren, Wenhao, Wang, Baisheng, Zhi, Ke-Qian, Zhi, Yuan   +5 more
core   +1 more source

Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis

mBio, 2023
Herpes simplex virus 1 (HSV-1) is a DNA virus belonging to the family Herpesviridae. HSV-1 infection causes severe neurological disease in the central nervous system (CNS), including encephalitis.
Xi-Qiu Xu, Tongran Xu, Wenting Ji, Chong Wang, Yujie Ren, Xiaobei Xiong, Xi Zhou, Shu-Hai Lin, Yi Xu, Yang Qiu   +9 more
doaj   +1 more source

Role and mechanism of ferroptosis in neurological diseases

Molecular Metabolism, 2022
Background: Ferroptosis, as a new form of cell death, is different from other cell deaths such as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of several diseases, including cancers, cardiovascular diseases, nervous ...
Mengmeng Ou, Ying Jiang, Yingying Ji, Qin Zhou, Zhiqiang Du, Haohao Zhu, Zhenhe Zhou   +6 more
doaj  

The roles of sirtuins in ferroptosis

Frontiers in Physiology, 2023
Ferroptosis represents a novel non-apoptotic form of regulated cell death that is driven by iron-dependent lipid peroxidation and plays vital roles in various diseases including cardiovascular diseases, neurodegenerative disorders and cancers. Plenty of iron metabolism-related proteins, regulators of lipid peroxidation, and oxidative stress-related ...
Jieqing Zeng, Junhao Guo, Si Huang, Yisen Cheng, Fei Luo, Xusan Xu, Riling Chen, Guoda Ma, Yajun Wang   +8 more
openaire   +3 more sources

Ferroptosis: machinery and regulation [PDF]

Autophagy, 2020
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron-containing enzyme lipoxygenase is the main promoter of ferroptosis by producing lipid hydroperoxides, and its function relies on the activation of ACSL4-dependent lipid ...
Xin Chen, Xin Chen, Rui Kang, Daolin Tang, Daolin Tang, Daniel J. Klionsky, Jingbo Li   +6 more
openaire   +3 more sources