Results 71 to 80 of about 155,094 (383)
Lysosome-dependent cell death and deregulated autophagy induced by amine-modified polystyrene nanoparticles [PDF]
, 2018 Nanoparticles (NPs) typically accumulate in lysosomes. However, their impact on lysosomal function, as well as autophagy, a lysosomal degradative pathway, is still not well known.
Boya, Patricia +2 more
core +20 more sources
Modelling ferroptosis in IPEC-J2 cells: insights into iron-dependent cell death
Italian Journal of Animal ScienceFerroptosis, a form of regulated cell death characterised by iron accumulation and lipid peroxidation, plays a crucial role in various diseases. However, its mechanisms in livestock, particularly in pigs, remain unclear.
Ching-Hsuan Liu, Yuan-Yu Lin
doaj +1 more source
A cell-permeable biscyclooctyne as a novel probe for the identification of protein sulfenic acids [PDF]
, 2016 Reactive oxygen species act as important second messengers in cell signaling and homeostasis through the oxidation of protein thiols. However, the dynamic nature of protein oxidation and the lack of sensitivity of existing molecular probes have hindered ...
Hartley, Richard C. +4 more
core +2 more sources
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging
Bioactive MaterialsFerroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as a cancer therapy requires a precisely targeted approach, which can be facilitated by using nanoparticles ...
Min Jun Ko +7 more
doaj +1 more source
Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma. [PDF]
, 2017 Recent data have indicated a fundamental role of iron in mediating a non-apoptotic and non-necrotic oxidative form of programmed cell death termed ferroptosis that requires abundant cytosolic free labile iron to promote membrane lipid peroxidation ...
Fanzani, Alessandro, Poli, Maura
core +1 more source
Ferroptosis: mechanisms and links with diseases
Signal Transduction and Targeted Therapy, 2021 Ferroptosis is an iron-dependent cell death, which is different from apoptosis, necrosis, autophagy, and other forms of cell death. The process of ferroptotic cell death is defined by the accumulation of lethal lipid species derived from the peroxidation
Hong-fa Yan +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Frontiers in Nutrition, 2021 Background: Iron is an essential nutrient involved in the redox cycle and the formation of free radicals. The reprogramming of iron metabolism is the main link to tumor cell survival.
Junfu Ma +6 more
doaj +1 more source
Circulation, 2023 Background: Myocardial ischemia-reperfusion (I/R) injury causes cardiac dysfunction to myocardial cell loss and fibrosis. Prevention of cell death is important to protect cardiac function after I/R injury.
Wenbin Cai +9 more
semanticscholar +1 more source