Results 111 to 120 of about 118,915,937 (305)

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Factors reducing in vitro fertilization success.

, 2013
A) When pooled sperm samples from 5 males were held for 1 or 2 h on ice and used to fertilize eggs from freshly squeezed individual females (N = 10 in vitro trials/ time point), there was no difference in their fertilization success at 1, 4 and 24 h (P>0.
Virginia L. Carter (319124), Mary Hagedorn (319120)   +1 more
core   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

ChatGPT’s Efficacy in Queries Regarding Polycystic Ovary Syndrome and Treatment Strategies for Women Experiencing Infertility

Diagnostics
This study assesses the efficacy of ChatGPT-4, an advanced artificial intelligence (AI) language model, in delivering precise and comprehensive answers to inquiries regarding managing polycystic ovary syndrome (PCOS)-related infertility.
Belgin Devranoglu, Tugba Gurbuz, Oya Gokmen   +2 more
doaj   +1 more source

Neurotensin stimulates the sperm acrosome reaction and reduces percentages of fertilization in vitro. [PDF]

F S Sci, 2020
Campbell GE, Jones EL, Comizzoli P, Duffy DM.   +3 more
europepmc   +1 more source

STRIDE: A Sequencing Depth Robust Metric for Sparse Chromosome Conformation Capture Data Comparison

Advanced Science, EarlyView.
A mean first passage time (MFPT)‐based representation transforms sparse Hi‐C contact maps into robust topological representations, preserving biologically meaningful chromatin features and facilitating robust analysis of TADs, chromatin loops, differential chromatin contacts, and sparse single‐cell Hi‐C data.
Bingxiang Xu, Xiaomeng Gao, Weichu Tao, Zhihua Zhang, Feifei Li   +4 more
wiley   +1 more source

Effect of dual tobacco smoking of hookah and cigarettes on semen parameters of infertile men

Tobacco Induced Diseases
Introduction The research regarding the effect of hookah smoking on health is still deficient, even though it has been proven to jeopardize human health by raising the hazard of different types of cancers, infections, and cardiovascular disease. We aimed
Soha Albeitawi, Jehan Hamadneh, Maha Alnatsheh, Ola Soudah, Ehab Abu Marar, Laith Ayarsrah, Mu'nis Alawneh, Rashed Husban, Raneem Alshraideh, Hussien Qablan   +9 more
doaj   +1 more source

Single‐Nucleus RNA Sequencing Identifies CREM as a Brake on Myofiber Hypertrophy in Chickens

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing on 91 144 nuclei from postnatal chicken pectoralis major between fast‐growing broilers (FG) and slow‐growing layers (SG) identifies the transcriptional factor CREM as a novel brake of myofiber hypertrophy. Mechanistically, functional validation experiments confirm that CREM activates the promoter of JUN and CREM deletion ...
Shuang Gu, Xiyu Zhao, Zheyi Jiang, Chaoliang Wen, Chaoyi Wang, Qiulian Wang, Qiang Huang, Fangren Lan, Shenghui Wu, Junying Li, Congjiao Sun, Huadong Yin, Ning Yang   +12 more
wiley   +1 more source

In vitro fertilization

, 1998
"June 26, 1998."; Discusses why in-vitro fertilization is not a mandated benefit in Connecticut, whether bills requiring coverage have been introduced, and what states require coverage.; Harvested from the web on 3/28 ...
Harleston, Jerome,
core  

Improving the safety of the embryo and the patient during in vitro fertilization procedures

, 2016
In vitro fertilization (IVF) is a method of treatment for infertility in selected indications. Recent years have brought dynamic development of technologies related to IVF.
Iwona Bojar, Artur Wdowiak, Edyta Wdowiak   +2 more
core   +1 more source