Results 61 to 70 of about 3,131,553 (238)

Community‐based child development service fetal alcohol spectrum disorder assessment: A retrospective clinic audit

, 2020
Aims: The aims of the current study were to: (i) report on the diagnostic profile of a group of children assessed for fetal alcohol spectrum disorder (FASD) using the Australian Guide to the Diagnosis of FASD; and (ii) to provide information and ...
Katsikitis, M, Heidi Webster, Jessica Doak, Webster, H, Doak, J, Mary Katsikitis   +5 more
core   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

An interaction between fetal sex and placental weight and efficiency predicts intrauterine growth in response to maternal protein insufficiency and gestational exposure window in a mouse model of FASD

Biology of Sex Differences, 2020
Background Individuals exposed to gestational stressors such as alcohol exhibit a spectrum of growth patterns, suggesting individualized responses to the stressors.
Sze Ting Cecilia Kwan, Brandon H. Presswood, Kaylee K. Helfrich, Joshua W. Baulch, Sandra M. Mooney, Susan M. Smith   +5 more
doaj   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Interventions for improving executive functions in children with Fetal Alcohol Spectrum Disorder: Systematic review and meta-analysis

, 2019
1.1 The problem, condition or issue Prenatal alcohol exposure (PAE) is associated with profound and lifelong disability. The umbrella term fetal alcohol spectrum disorder (FASD) describes a spectrum of impairments resulting from the deleterious effects ...
Eggins, Elizabeth, Doug Shelton, Betts, Joseph, Harnett, Paul, Till, H, Joseph Betts, Betts, J, Shelton, D, Chandler-Mather, N, Ned Chandler‐Mather, Shelton, Doug, Eggins, E, Harnett, P, Chandler-Mather, Ned, Elizabeth Eggins, Till, Haydn, Haydn Till, Paul Harnett, Sharon Dawe, Dawe, Sharon, Dawe, S   +20 more
core   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review

BMC Psychology, 2017
Background In an effort to improve the screening and diagnosis of individuals with Fetal Alcohol Spectrum Disorder (FASD), research has focused on the identification of a unique neurodevelopmental profile characteristic of this population.
Shannon Lange, Joanne Rovet, Jürgen Rehm, Svetlana Popova   +3 more
doaj   +1 more source

Resources to Support Employment of Individuals with Fetal Alcohol Spectrum Disorder and Criminal Justice System Background: A Scoping Review Protocol

, 2021
Amendment to "Resources to Support Employment of Individuals with Fetal Alcohol Spectrum Disorder and Criminal Justice System Background: A Scoping Review ...
Carmela Pestell, Richard Cash, Kirsten Panton, Marie M A Nankoo, Dr Joanna Alexi, Dr James Fitzpatrick, Isabelle Adams   +6 more
core   +1 more source

Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis

Advanced Science, EarlyView.
Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He, Ya Jin, Guosheng Liu, Hao Liu, Xinyi Zhu, Weipeng Xu, Wei Li, Meiyao He, Yao Shen, Bingxiao Li, Xuesong Yang, Xiaoyu Wang, Shasha Han   +12 more
wiley   +1 more source

DNA methylation as a predictor of fetal alcohol spectrum disorder

Clinical Epigenetics, 2018
Background Fetal alcohol spectrum disorder (FASD) is a developmental disorder that manifests through a range of cognitive, adaptive, physiological, and neurobiological deficits resulting from prenatal alcohol exposure.
Alexandre A. Lussier, Alexander M. Morin, Julia L. MacIsaac, Jenny Salmon, Joanne Weinberg, James N. Reynolds, Paul Pavlidis, Albert E. Chudley, Michael S. Kobor   +8 more
doaj   +1 more source