Results 101 to 110 of about 60,676 (321)

Stepwise Regulation of Cellular Oxidative Stress via Conductive‐Piezoelectric Integrated Microstructured Conduits for Enhanced Nerve Regeneration

Advanced Science, EarlyView.
This study presents a conductive‐piezoelectric integrated microstructured conduit for peripheral nerve regeneration. The conduit combines reduced graphene oxide with a piezoelectric nanofiber membrane, enhancing nerve repair through physical guidance, oxidative stress inhibition, and ultrasound‐activated electrical stimulation.
Dong Zhou, Mengxuan Bian, Lingyu Wei, Binghuang Yao, Qi Chen, Lan Xiao, Jing He, Jian Zhang, Yulin Li, Libo Jiang   +9 more
wiley   +1 more source

Adequacy of Maternal Iron Status Protects against Behavioral, Neuroanatomical, and Growth Deficits in Fetal Alcohol Spectrum Disorders [PDF]

, 2012
Fetal alcohol spectrum disorders (FASD) are the leading non-genetic cause of neurodevelopmental disability in children. Although alcohol is clearly teratogenic, environmental factors such as gravidity and socioeconomic status significantly modify ...
Echoleah S. Rufer, George R. Flentke, Jonathan I. Matsui, Matthew E. Andrzejewski, Megan M. Attridge, Susan M. Smith, Tuan D. Tran   +6 more
core   +3 more sources

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Analysis of alcohol-metabolizing enzymes genetic variants and RAR/RXR expression in patients diagnosed with fetal alcohol syndrome: a case-control study

BMC Genomics
Understanding the mechanisms underlying alcohol metabolism and its regulation, including the effect of polymorphisms in alcohol-metabolizing enzymes, is crucial for research on Fetal Alcohol Spectrum Disorders.
Melina Vieiros, Elisabet Navarro-Tapia, Anna Ramos-Triguero, Àgueda García-Meseguer, Leopoldo Martínez, Óscar García-Algar, Vicente Andreu-Fernández   +6 more
doaj   +1 more source

Automated cerebellar segmentation: Validation and application to detect smaller volumes in children prenatally exposed to alcohol

NeuroImage: Clinical, 2014
Objective: To validate an automated cerebellar segmentation method based on active shape and appearance modeling and then segment the cerebellum on images acquired from adolescents with histories of prenatal alcohol exposure (PAE) and non-exposed ...
Valerie A. Cardenas, Mathew Price, M. Alejandra Infante, Eileen M. Moore, Sarah N. Mattson, Edward P. Riley, George Fein   +6 more
doaj   +1 more source

Decline and fall:a biological, developmental, and psycholinguistic account of deliberative language processes and ageing [PDF]

, 2011
Background: This paper reviews the role of deliberative processes in language: those language processes that require central resources, in contrast to the automatic processes of lexicalisation, word retrieval, and parsing.
Harley, Trevor A., Jessiman, Lesley J., MacAndrew, Siobhan B. G.   +2 more
core   +2 more sources

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Computational prediction of gene targets for fetal alcohol spectrum disorders [PDF]

, 2010
PhD, Faculty of Health Sciences, University of the Witwatersrand, 2008Fetal alcohol spectrum disorders (FASD) describe the range of disorders that result from in utero alcohol exposure.
Lombard, Zane
core  

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Older Pregnant Women and Binge Drinking: Increasing the Risk of Fetal Alcohol Spectrum Disorder [PDF]

, 2011
Identifying maternal characteristics that increase the risk of Fetal Alcohol Spectrum Disorders (FASD) is a critical step toward creating targeted pregnancy intervention.
Staff, Editorial
core   +1 more source