Results 51 to 60 of about 826,759 (374)
Genome editing of HBG1 and HBG2 to induce fetal hemoglobin.
Blood Advances, 2019 Induction of fetal hemoglobin (HbF) via clustered regularly interspaced short palindromic repeats/Cas9-mediated disruption of DNA regulatory elements that repress γ-globin gene (HBG1 and HBG2) expression is a promising therapeutic strategy for sickle ...
J. Métais +26 more
semanticscholar +1 more source
Haematological Characterisation and Molecular Basis of Asian Indian Inversion Deletions Delta Beta Thalassemia: A Case Report [PDF]
Journal of Clinical and Diagnostic Research, 2014 The hereditary persistence of fetal hemoglobin (HPFH) and delta beta thalassemia are heterogeneous disorders characterised by increased levels of fetal hemoglobin and high level of this Hb continues in adulthood.
Jitender Mohan Khunger +4 more
doaj +1 more source
Micronutrient Intake and Fundal Height Determine Birth Weight [PDF]
, 2019 The birth weight (BW) are utilized as indicators of the healthy and term newborns. Factor that affects the weight of a newborn are micronutrient intake and fundal height. Folic acid and iron (Fe) were associated with newborn birth weight.
Aghadiati, F. (Faradina) +2 more
core +3 more sources
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Science, 2018 A CRISPR screen for RBC regulators Hemoglobin in red blood cells (RBCs) carries oxygen to the tissues. Sickle cell disease is an inherited condition that involves abnormal hemoglobin.
Jeremy D. Grevet +18 more
semanticscholar +1 more source
A new target for fetal hemoglobin reactivation
Haematologica, 2019 Angela Rivers +2 more
doaj +4 more sources
Hemoglobin FHouston: A Fetal Variant [PDF]
Blood, 1966 Abstract A fetal hemoglobin variant, designated hemoglobin FHouston, was found in the cord blood sample of a healthy, term Negro infant. The variant, comprising about 15 per cent of the total cord blood hemoglobin, diminished concomitantly with hemoglobin F, and it was barely detectable in the blood when the infant was 4 months old.
Rose G. Schneider +3 more
openaire +3 more sources
Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus.
Blood, 2018 Naturally occurring, large deletions in the β-globin locus result in hereditary persistence of fetal hemoglobin, a condition that mitigates the clinical severity of sickle cell disease (SCD) and β-thalassemia.
C. Antoniani +18 more
semanticscholar +1 more source
What influences Hb fetal production in adulthood?
Revista Brasileira de Hematologia e Hemoterapia, 2011 Human hemoglobin genes are located in α and β globin gene clusters in chromosomes 16 and 11, respectively. Different types of hemoglobin are synthesized according to the stage of development with fetal hemoglobin (α2γ2) (Hb F) being ...
Gisele Cristine de Souza Carrocini +2 more
doaj +1 more source
Experimental biology and medicine, 2019 Individuals with sickle cell disease have severe anemia due to the production of abnormal hemoglobin S, chronic red blood cell hemolysis, and increased oxidative stress leading to endothelial cell dysfunction, vasculopathy, and progressive organ damage ...
Xingguo Zhu +4 more
semanticscholar +1 more source
Fetal Hemoglobin Induction by Epigenetic Drugs.
Seminars in hematology (Print), 2018 Fetal hemoglobin (HbF) inhibits the root cause of sickle pathophysiology, sickle hemoglobin polymerization. Individuals who naturally express high levels of HbF beyond infancy thus receive some protection from sickle complications.
D. Lavelle +2 more
semanticscholar +1 more source