Results 61 to 70 of about 832,435 (375)

Anemia Prevalence among Pregnant Women and Birth Weight in Five Areas in China [PDF]

, 2009
Objectives: To investigate the current prevalence of anemia among pregnant women in different areas of China and the association with birth weight and educational level.
Li, Y., Ma, A.G., Schouten, E.G., Sun, Y.Y., Wang, Q.Z., Wang, Y., Xu, R.X., Zheng, M.C.   +7 more
core   +2 more sources

A clinically meaningful fetal hemoglobin threshold for children with sickle cell anemia during hydroxyurea therapy

American journal of hematology/oncology, 2017
Hydroxyurea has proven clinical benefits and is recommended to be offered to all children with sickle cell anemia (SCA), but the optimal dosing regimen remains controversial. Induction of red blood cell fetal hemoglobin (HbF) by hydroxyurea appears to be
J. Estepp, M. Smeltzer, G. Kang, Chen Li, Winfred C. Wang, Christina M. Abrams, B. Aygun, R. Ware, K. Nottage, J. Hankins   +9 more
semanticscholar   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Patients with sickle cell disease taking hydroxyurea in the Hemocentro Regional de Montes Claros

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: The development of therapies for sickle cell disease has received special attention, particularly those that reduce the polymerization of hemoglobin S.
Fernanda Kelle de Souza Santos, Caroline Nogueira Maia   +1 more
doaj   +1 more source

Studies on the Hemoglobin of Cooley's Anemia and Cooley's Trait [PDF]

, 1952
The diseases sickle cell anemia and Cooley's anemia (also known as thalassemia or Mediterranean anemia) have associated with them "minor" or "trait" forms of the disease in which the symptomatology is minimal, and the abnormalities in the red cells are ...
Rich, Alexander
core  

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element

Genes & Development, 2017
In this study, Huang et al. compared the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chromatin structures and compartments A/B are highly similar at both developmental stages.
Peng Huang, C. Keller, B. Giardine, Jeremy D. Grevet, J. Davies, J. Hughes, R. Kurita, Yukio Nakamura, R. Hardison, G. Blobel   +9 more
semanticscholar   +1 more source

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

FEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
wiley   +1 more source

Abnormal hemoglobins in Malta : the significance of two fetal and an adult variant [PDF]

, 1972
The study of human hemoglobin variants has a special place in hemoglobin research. The discovery of hemoglobin F (Malta) by Cauchi et al. (1969) and the high incidence of this hemoglobin in Maltese newborns gave us the opportunity to initiate a ...
Bannister, William H., Grech, J.L., Huisman, Titus Hendrik Jan, Schroeder, W.A.   +3 more
core  

Disorders of the synthesis of human fetal hemoglobin [PDF]

IUBMB Life, 2008
AbstractFetal hemoglobin (HbF), the predominant hemoglobin in the fetus, is a mixture of two molecular species (α2Gγ2 and α2Aγ2) that differ only at position 136 reflecting the products of two nonallelic γ‐globin genes. At the time of birth, HbF accounts for ∼70% of the total Hb.
MANCA, Laura, MASALA, Bruno Lucio
openaire   +4 more sources

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source