Results 71 to 80 of about 832,435 (375)

Variants of hemoglobin F and observations on hemoglobin F (Malta) [PDF]

, 1970
The major hemoglobin component found in the blood of humans at birth is fetal hemoglobin, hemoglobin F. In common with most other human hemoglobins it has a tetrameric structure, each molecule being made up of two different pairs of polypeptide chains ...
Brown, I.R.F., Grech, J.L.
core  

Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases. [PDF]

, 2016
We examined the efficiency, specificity, and mutational signatures of zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 systems designed to
Bjurström, Carmen F, Cooper, Aaron, Hollis, Roger P, Kaufman, Michael, Kohn, Donald B, Kuo, Caroline, Lai, Stephen, Lill, Georgia R, Mojadidi, Michelle, Phillips, John, Urbinati, Fabrizia, Wang, Xiaoyan   +11 more
core   +3 more sources

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.

Blood, 2016
Overcoming the silencing of the fetal γ-globin gene has been a long-standing goal in the treatment of sickle cell disease (SCD). The major transcriptional enhancer of the β-globin locus, called the locus control region (LCR), dynamically interacts with ...
L. Breda, I. Motta, S. Lourenço, Chiara Gemmo, Wulan Deng, J. Rupon, O. Abdulmalik, D. Manwani, G. Blobel, S. Rivella   +9 more
semanticscholar   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Índice cárdio-femoral para avaliação da anemia de fetos de gestantes isoimunizadas Cardiofemoral index for the evaluation of fetal anemia in isoimmunized pregnancies

Revista Brasileira de Ginecologia e Obstetrícia, 2005
OBJETIVO: estabelecer novo marcador não invasivo na detecção da anemia fetal, em gestantes isoimunizadas por antígenos eritrocitários. MÉTODOS: em estudo transversal o índice ecográfico obtido pela razão entre a medida ecográfica do diâmetro ...
Antônio Carlos Vieira Cabral, Thales Bittencourt de Barcelos, Isabela Gomes Melo Apocalipse, Henrique Vitor Leite, Zilma Silveira Nogueira Reis   +4 more
doaj   +1 more source

Genome-wide analysis of aberrantly expressed lncRNAs and miRNAs with associated co-expression and ceRNA networks in β-thalassemia and hereditary persistence of fetal hemoglobin

OncoTarget, 2017
The implications of lncRNAs regarding fetal hemoglobin (HbF) induction in hemoglobin disorders remain poorly understood. In this study, microarray analysis was performed to profile lncRNAs, miRNAs and mRNAs in individuals with hereditary persistence of ...
Ketong Lai, Siyuan Jia, Shanjuan Yu, Jianmin Luo, Yunyan He   +4 more
semanticscholar   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin

Haematologica, 2011
The persistence of high fetal hemoglobin level in adults may ameliorate the clinical phenotype of beta-thalassemia and sickle cell anemia. Several genetic variants responsible for hereditary persistence of fetal hemoglobin, linked and not linked to the ...
Stefania Satta, Lucia Perseu, Paolo Moi, Isadora Asunis, Annalisa Cabriolu, Liliana Maccioni, Franca Rosa Demartis, Laura Manunza, Antonio Cao, Renzo Galanello   +9 more
doaj   +1 more source

Oxygen targeting in preterm infants: a physiological interpretation. [PDF]

, 2015
Randomized controlled trials evaluating low-target oxygen saturation (SpO2:85% to 89%) vs high-target SpO2 (91% to 95%) have shown variable results regarding mortality and morbidity in extremely preterm infants.
Lakshminrusimha, S, Manja, V, Mathew, B, Suresh, GK   +3 more
core  

Acrylamide: Increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans [PDF]

, 2002
We have developed a liquid chromatography/mass spectrometry (LC-MS/MS) assay to determine acrylamide in various body fluids. The assay also allows the reliable quantitation of acrylamide in food. In a total of 11 healthy male and female subjects, we were
Hofmann, A., Illauera, M., Kinzig-Schippers, M., Landersdorfer, C., Skott, A., Sorgel, F., Weissenbacher, R.   +6 more
core   +1 more source