Results 71 to 80 of about 821,341 (299)
Studies on the Hemoglobin of Cooley's Anemia and Cooley's Trait [PDF]
, 1952 The diseases sickle cell anemia and Cooley's anemia (also known as thalassemia or Mediterranean anemia) have associated with them "minor" or "trait" forms of the disease in which the symptomatology is minimal, and the abnormalities in the red cells are ...
Rich, Alexander
core
Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia [PDF]
, 2017 Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown.
Hodges, James S. +8 more
core +2 more sources
Disorders of the synthesis of human fetal hemoglobin [PDF]
IUBMB Life, 2008 AbstractFetal hemoglobin (HbF), the predominant hemoglobin in the fetus, is a mixture of two molecular species (α2Gγ2 and α2Aγ2) that differ only at position 136 reflecting the products of two nonallelic γ‐globin genes. At the time of birth, HbF accounts for ∼70% of the total Hb.
MANCA, Laura, MASALA, Bruno Lucio
openaire +4 more sources
Genes & Development, 2017 In this study, Huang et al. compared the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chromatin structures and compartments A/B are highly similar at both developmental stages.
Peng Huang +9 more
semanticscholar +1 more source
Abnormal hemoglobins in Malta : the significance of two fetal and an adult variant [PDF]
, 1972 The study of human hemoglobin variants has a special place in hemoglobin research. The discovery of hemoglobin F (Malta) by Cauchi et al. (1969) and the high incidence of this hemoglobin in Maltese newborns gave us the opportunity to initiate a ...
Bannister, William H. +3 more
core
Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases. [PDF]
, 2016 We examined the efficiency, specificity, and mutational signatures of zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 systems designed to
Bjurström, Carmen F +11 more
core +3 more sources
Variants of hemoglobin F and observations on hemoglobin F (Malta) [PDF]
, 1970 The major hemoglobin component found in the blood of humans at birth is fetal hemoglobin, hemoglobin F. In common with most other human hemoglobins it has a tetrameric structure, each molecule being made up of two different pairs of polypeptide chains ...
Brown, I.R.F., Grech, J.L.
core
Joint analysis of functional genomic data and genome-wide association studies of 18 human traits
, 2014 Annotations of gene structures and regulatory elements can inform genome-wide association studies (GWAS). However, choosing the relevant annotations for interpreting an association study of a given trait remains challenging.
Pickrell, Joseph K.
core +1 more source
Revista Brasileira de Ginecologia e Obstetrícia, 2005 OBJETIVO: estabelecer novo marcador não invasivo na detecção da anemia fetal, em gestantes isoimunizadas por antígenos eritrocitários. MÉTODOS: em estudo transversal o índice ecográfico obtido pela razão entre a medida ecográfica do diâmetro ...
Antônio Carlos Vieira Cabral +4 more
doaj +1 more source
Blood, 2016 Overcoming the silencing of the fetal γ-globin gene has been a long-standing goal in the treatment of sickle cell disease (SCD). The major transcriptional enhancer of the β-globin locus, called the locus control region (LCR), dynamically interacts with ...
L. Breda +9 more
semanticscholar +1 more source