Fetal hypoxia results in sex- and cell type-specific alterations in neonatal transcription in rat oligodendrocyte precursor cells, microglia, neurons, and oligodendrocytes [PDF]
Cell & Bioscience, 2023 Background Fetal hypoxia causes vital, systemic, developmental malformations in the fetus, particularly in the brain, and increases the risk of diseases in later life. We previously demonstrated that fetal hypoxia exposure increases the susceptibility of
Isaac Kremsky +8 more
doaj +2 more sources
Nucleated Red Blood Cells as a Marker of Acute and Chronic Fetal Hypoxia in a Rat Model [PDF]
Rambam Maimonides Medical Journal, 2017 Objective To examine the relationship between duration of fetal hypoxia, nucleated red blood cell (NRBC) count, and fetal growth. Methods Pregnant rats were exposed to a severe hypoxia (9.5%–10% O2) for varying time intervals (2, 6, 12, 24, 48, and ...
Victoria K. Minior +4 more
doaj +2 more sources
Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia [PDF]
Frontiers in Physiology, 2019 Pregnancy complications associated with chronic fetal hypoxia have been linked to the development of adult cardiovascular disease in the offspring. Prenatal hypoxia has been shown to increase placental oxidative stress and impair placental function in a ...
Esha Ganguly +18 more
doaj +2 more sources
Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood [PDF]
Frontiers in PhysiologyIntroductionChronic fetal hypoxia is commonly associated with fetal growth restriction and can predispose to respiratory disease at birth and in later life. Antenatal antioxidant treatment has been investigated to overcome the effects of oxidative stress
Erin V. McGillick +16 more
doaj +2 more sources
Fetal hypoxia and apoptosis following maternal porcine reproductive and respiratory syndrome virus (PRRSV) infection [PDF]
BMC Veterinary Research, 2021 Background Mechanisms of fetal death following maternal PRRSV2 infection remain uncharacterized, although hypoxia from umbilical cord lesions and/or placental detachment due to apoptosis are hypothesized.
Carolina M. Malgarin +6 more
doaj +2 more sources
Antioxidants: powering the fight against fetal hypoxia. [PDF]
Philos Trans R Soc Lond B Biol SciHypoxia is a common challenge in fetal development. Short-term acute episodes occur during labour owing to uterine contractions or umbilical cord compression. In response, the fetus prioritizes oxygen and nutrient delivery to the brain, heart and adrenal glands at the expense of other organs, a mechanism known as the fetal brain-sparing response ...
Botting-Lawford KJ +4 more
europepmc +5 more sources
Conserved gene expression patterns in the placenta underlie pregnancy complications associated with hypoxia in mice and humans [PDF]
Cellular and Molecular Life SciencesDuring pregnancy hypoxia leads to complications like fetal growth restriction (FGR). Maternal inhalation hypoxia during late murine pregnancy impairs placental phenotype and fetal development in a severity-dependent manner.
Emma J Siragher +4 more
doaj +2 more sources
RUDN Journal of Medicine, 2021 Relevance . Intrauterine hypoxia associated with placental disorders is a significant factor of ante-, intra- and postnatal fetal and newborn death.
Natallia V. Matskevich, Marina P. Famina
doaj +1 more source
Types of intrapartum hypoxia in the newborn at term with metabolic acidemia: A retrospective study
Acta Obstetricia et Gynecologica Scandinavica, 2022 Introduction In the most recent recommendations of the International Federation of Gynecology and Obstetrics (FIGO), a chapter was dedicated to the physiological approach and to the description of fetal mechanisms developed to respond to hypoxia.
Léa Descourvieres +7 more
doaj +1 more source
Analysis of development of fetal hypoxia as a common complication of pregnancy and labor
Лечащий Врач, 2022 Due to insufficient oxygen supply to the fetus, which is called hypoxia, adverse changes occur in its body. In the total number of births, it is 10,5%. Fetal hypoxia is not an independent disease.
E. V. Semeleva +2 more
doaj +1 more source