Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia [PDF]
Frontiers in Physiology, 2019 Pregnancy complications associated with chronic fetal hypoxia have been linked to the development of adult cardiovascular disease in the offspring. Prenatal hypoxia has been shown to increase placental oxidative stress and impair placental function in a ...
Esha Ganguly +18 more
doaj +3 more sources
Nucleated Red Blood Cells as a Marker of Acute and Chronic Fetal Hypoxia in a Rat Model [PDF]
Rambam Maimonides Medical Journal, 2017 Objective To examine the relationship between duration of fetal hypoxia, nucleated red blood cell (NRBC) count, and fetal growth. Methods Pregnant rats were exposed to a severe hypoxia (9.5%–10% O2) for varying time intervals (2, 6, 12, 24, 48, and ...
Victoria K. Minior +4 more
doaj +3 more sources
Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood [PDF]
Frontiers in PhysiologyIntroductionChronic fetal hypoxia is commonly associated with fetal growth restriction and can predispose to respiratory disease at birth and in later life. Antenatal antioxidant treatment has been investigated to overcome the effects of oxidative stress
Erin V. McGillick +16 more
doaj +4 more sources
Does the Biological Response to Fetal Hypoxia Involve Angiogenesis, Placental Enlargement and Preeclampsia? [PDF]
Paediatr Perinat Epidemiol, 2016 From an evolutionary point of view, an overriding biological priority is to ensure offspring survival. Oxygen is essential for the growing fetus, and during pregnancy the fetus has an increasing demand for oxygen.
Eskild A, Strøm-Roum EM, Haavaldsen C.
europepmc +4 more sources
The Effects of In Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain. [PDF]
Oxid Med Cell Longev, 2022 Near‐term acute hypoxia in utero can result in significant fetal brain injury, with some brain regions more vulnerable than others. As mitochondrial dysfunction is an underlying feature of the injury cascade following hypoxia, this study is aimed at ...
Muccini AM +6 more
europepmc +2 more sources
Fetal hypoxia results in sex- and cell type-specific alterations in neonatal transcription in rat oligodendrocyte precursor cells, microglia, neurons, and oligodendrocytes [PDF]
Cell & Bioscience, 2023 Background Fetal hypoxia causes vital, systemic, developmental malformations in the fetus, particularly in the brain, and increases the risk of diseases in later life. We previously demonstrated that fetal hypoxia exposure increases the susceptibility of
Isaac Kremsky +8 more
doaj +2 more sources
Impact of Chronic Fetal Hypoxia and Inflammation on Cardiac Pacemaker Cell Development. [PDF]
Cells, 2020 Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease.
Frasch MG, Giussani DA.
europepmc +3 more sources
Fetal Hypoxia Impacts on Proliferation and Differentiation of Sca-1+ Cardiac Progenitor Cells and Maturation of Cardiomyocytes: A Role of MicroRNA-210. [PDF]
Genes (Basel), 2020 Hypoxia is one of the most frequent and severe stresses to an organism’s homeostatic mechanisms, and hypoxia during gestation has profound adverse effects on the heart development increasing the occurrence of congenital heart defects (CHDs).
Meng X, Zhang P, Zhang L.
europepmc +2 more sources
Computer-Aided Diagnosis System of Fetal Hypoxia Incorporating Recurrence Plot With Convolutional Neural Network. [PDF]
Front Physiol, 2019 Background: Electronic fetal monitoring (EFM) is widely applied as a routine diagnostic tool by clinicians using fetal heart rate (FHR) signals to prevent fetal hypoxia.
Zhao Z, Zhang Y, Comert Z, Deng Y.
europepmc +2 more sources
Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review. [PDF]
Sensors (Basel), 2018 This article reviews existing clinical practices and sensor research undertaken to monitor fetal well-being during labour. Current clinical practices that include fetal heart rate monitoring and fetal scalp blood sampling are shown to be either ...
Cummins G +9 more
europepmc +2 more sources