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Identifying Key Questions and Challenges in Microchimerism Biology [PDF]

Advanced Science
Microchimerism research has recently gained renewed attention despite known existence of these rare cells for decades. Fetal and maternal microchimeric‐derived cells may have functional capabilities, and are increasingly associated with both beneficial ...
Kristine J. Chua, Rachel C. Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W. Bianchi, Hyun‐Dong Chang, Henderson J. Cleaves II, Michael Eikmans, Heidi E. S. Fjeldstad, David Haig, Whitney E. Harrington, William Horsnell, Daniel P. Jacobsen, Mads Kamper‐Jørgensen, Sami B. Kanaan, Kiarash Khosrotehrani, Nathalie C. Lambert, J. Lee Nelson, Maria B. Olsen, Tiffany D. Pan, Jelmer R. Prins, Frank A. Schildberg, Anne Cathrine Staff, Anders Ståhlberg, Ina A. Stelzer, Christopher Urbschat, Sing Sing Way, Melissa A. Wilson, Jody Ye, Thomas Kroneis, Amy M. Boddy   +31 more
doaj   +3 more sources

Fetal microchimerism and implications for maternal health. [PDF]

Obstet Med, 2020
This review paper outlines the definition, pathophysiology, and potential maternal health consequences of cellular fetal microchimerism, the maternal acquisition of intact cells of fetal origin during pregnancy. Increased rates and amounts of cellular fetal microchimerism are associated with several placental syndromes, including preeclampsia and ...
Fjeldstad HE, Johnsen GM, Staff AC.
europepmc   +6 more sources

Fetal microchimerism in mouse caerulein-induced pancreatitis model [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Fetal microchimerism is the persistence of allogeneic cell population that transfer from the fetus to the mother. The aim of this study was to evaluate the presence of fetal microchimerism in the pancreas of the mouse with acute ...
Zahra Vojdani, Jafar Bagheri, Tahereh Talaei-Khozani, Negar Azarpira, Mahin Salmannjad, Ali Farokhi   +5 more
doaj   +4 more sources

Cellular fetal microchimerism in preeclampsia. [PDF]

Hypertension, 2013
Previous studies have shown elevated concentrations of free fetal DNA and erythroblasts in maternal circulation in women with preeclampsia compared with those with normal pregnancy. Pluripotent and immunocompetent fetal cells also transfer to the maternal circulation during pregnancy, but whether concentrations of fetal mononuclear cells ...
Gammill HS, Aydelotte TM, Guthrie KA, Nkwopara EC, Nelson JL.   +4 more
europepmc   +4 more sources

Heterogeneous Distribution of Fetal Microchimerism in Local Breast Cancer Environment. [PDF]

PLoS ONE, 2016
Fetal cells enter maternal circulation during pregnancy and persist in the woman's body for decades, achieving a form of physiological microchimerism. These cells were also evidenced in tumors.
Dragos Nemescu, Ramona Gabriela Ursu, Elena Roxana Nemescu, Lucian Negura   +3 more
doaj   +2 more sources

Fetal microchimerism in human brain tumors. [PDF]

Brain Pathol, 2018
AbstractSex differences in cancer incidence and survival, including central nervous system tumors, are well documented. Multiple mechanisms contribute to sex differences in health and disease. Recently, the presence of fetal‐in‐maternal microchimeric cells has been shown to have prognostic significance in breast and colorectal cancers.
Broestl L, Rubin JB, Dahiya S.
europepmc   +4 more sources

Fetal microchimerism and cancer. [PDF]

Cancer Res, 2008
Abstract The persistence of fetal stem cells with multilineage potential in women who have been pregnant, a phenomenon known as fetal microchimerism, is emerging as a potential contributing factor in certain diseases, including cancer. For example, fetal microchimerism has been implicated in autoimmune disease, wound healing, and cancer.
Sawicki JA.
europepmc   +4 more sources

Y-chromosome DNA is present in the blood of female dogs suggesting the presence of fetal microchimerism. [PDF]

PLoS ONE, 2013
Fetal microchimerism has been suggested to play contradictory roles in women's health, with factors including age of the recipient, time elapsed since microchimerism occurred, and microchimeric cell type modulating disease.
Sandra M Axiak-Bechtel, Senthil R Kumar, Sarah A Hansen, Jeffrey N Bryan   +3 more
doaj   +2 more sources

Fetal microchimerism in skin wound healing. [PDF]

Chimerism, 2012
Skin wound healing is a complex regenerative process involving various cell types. We recently investigated whether fetal microchimeric cells (FMCs) acquired during gestation contribute to maternal wound healing and used fetal microchimerism to investigate the recruitment of distant endothelial progenitor cells in skin wounds.
Nassar D, Khosrotehrani K, Aractingi S.
europepmc   +5 more sources

Maternal and fetal microchimerism in granulocytes. [PDF]

Chimerism, 2010
Cell trafficking during pregnancy may result in durable microchimerism, both fetal microchimerism in the mother and maternal microchimerism in her children. Whether microchimerism is continuously replenished has not been well-described. To address this question, we isolated granulocytes, cells with relatively short half-lives, from peripheral blood of ...
Sunku CC, Gadi VK, de Laval de Lacoste B, Guthrie KA, Nelson JL.   +4 more
europepmc   +4 more sources