Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb [PDF]
, 1999 Background. We previously reported the association among donor leukocyte chimerism, apoptosis of presumedly IL-2-deficient graft-infiltrating host cells, and the spontaneous donor-specific tolerance induced by liver but not heart allografts in mice ...
Angus W. Thomson +63 more
core +1 more source
Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy. [PDF]
, 2015 INTRODUCTION: Microchimeric cells have been studied for over a decade, with conflicting reports on their presence and role in autoimmune and other inflammatory diseases.
Artlett, Carol M +4 more
core +2 more sources
Do maternal cells trigger or perpetuate autoimmune diseases in children?
Pediatric Rheumatology Online Journal, 2007 The placental barrier is not the impenetrable wall that it was once presumed to be. During pregnancy, fetal cells pass into the mother, where they persist for decades after the pregnancy, leading to fetal microchimerism (FMc).
Stevens Anne M
doaj +1 more source
Long-term persistence and effects of fetal microchimerisms on disease onset and status in a cohort of women with rheumatoid arthritis and systemic lupus erythematosus [PDF]
, 2013 BACKGROUND: The discovery of a fetal cells transfer to the mother is a phenomenon with multiple implications for autoimmunity and tolerance. The prevalence and meaning of the feto-maternal microchimerism (MC) in rheumatic diseases has not been thoroughly
Jörn Kekow +5 more
core +1 more source
Graft versus host disease and microchimerism in a JAK3 deficient patient
Allergy, Asthma & Clinical Immunology, 2019 Background The lymphohematopoietic cells originating from feto-maternal trafficking during pregnancy may cause microchimerism and lead to materno-fetal graft versus host disease (GVHD) in severe combined immunodeficiency (SCID) patients.
Zahra Shahbazi +9 more
doaj +1 more source
Intrathyroidal Fetal Microchimerism in Pregnancy and Postpartum [PDF]
Endocrinology, 2002 To investigate a possible relationship between fetal microchimerism and autoimmune thyroiditis, we looked for the presence of fetal cells in the maternal blood and thyroid gland in murine experimental autoimmune thyroiditis (EAT). We used a quantitative PCR-ELISA for products of the SRY locus on the Y chromosome to detect fetal male cells during ...
M, Imaizumi +3 more
openaire +2 more sources
Survey of commercial antibodies targeting Y chromosome‐encoded genes
, 2023 MedComm – Future Medicine, Volume 2, Issue 4, December 2023.
Bradley D. Gelfand +3 more
wiley +1 more source
Pregnancy, microchimerism, and the maternal grandmother.
PLoS ONE, 2011 BackgroundA WOMAN OF REPRODUCTIVE AGE OFTEN HARBORS A SMALL NUMBER OF FOREIGN CELLS, REFERRED TO AS MICROCHIMERISM: a preexisting population of cells acquired during fetal life from her own mother, and newly acquired populations from her pregnancies.
Hilary S Gammill +6 more
doaj +1 more source
CCL2 recruits fetal microchimeric cells and dampens maternal brain damage in post-partum mice
Neurobiology of Disease, 2022 Preventing brain cell loss and enhancing tissue repair are crucial objectives to improve the outcome of stroke. Fetal microchimerism has been implicated in brain repair following ischemic stroke in mice.
Maria Sbeih +8 more
doaj +1 more source
Fetal Microchimerism in Women with Breast Cancer [PDF]
Cancer Research, 2007 Abstract Fetal microchimerism (FMc) describes long-term persistence of small numbers of fetal-derived allogeneic cells in the mother. Although FMc has been implicated as a mechanism of autoimmune disease, it may confer a beneficial effect with immune surveillance of malignant cells.
Vijayakrishna K, Gadi, J Lee, Nelson
openaire +2 more sources