Results 61 to 70 of about 7,077,080 (366)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Microanatomy of the enteric neurons and glia; expression patterns of the PGP9.5, S100b proteins, RET and SOX10 genes in the human fetal gut wall

Translational Research in Anatomy
Background: Enteric nervous system comprises enteric neurons and glia, derived from neural crest cells, and regulates the gastrointestinal function. Previous animal studies have highlighted the essential roles of RET and SOX10 genes, along with PGP9.5 ...
Chacchu Bhattarai, Phanindra Prasad Poudel, Arnab Ghosh, Saman Man Pradhan, Nirmal Panthi, Dela Singh Joshi, Shanti Khadka, Sandhya Kumari, Guruprasad Kalthur, Vani Lakshmi R, Sujan Gautam, Sneha Guruprasad Kalthur   +11 more
doaj   +1 more source

Screening circulating proteins to identify biomarkers of fetal macrosomia

BMC Research Notes, 2019
Objective Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal traumatic injuries, and perinatal death.
Tess Cruickshank, Tu’uhevaha J. Kaitu’u-Lino, Ping Cannon, Alesia Harper, Tuong-Vi Nguyen, Kirsten M. Dane, Anna L. Middleton, Valerie P. Kyritsis, Roxanne Hastie, Stephen Tong, Susan P. Walker, Teresa M. MacDonald   +11 more
doaj   +1 more source

Cardiac hypertrophy and heart failure: from the case to review of literature [PDF]

, 2016
In response to an increased workload due to physiological or pathological stimuli, the heart may undergo a process of growth with increased muscle mass called cardiac hypertrophy. It is a particular mechanism of long term compensation used by the heart
Massoni, Francesco, Onofri, Emanuela, Ricci, Lidia, Ricci, Serafino, Simeone, Claudio   +4 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Neuroprotective peptide ADNF-9 in fetal brain of C57BL/6 mice exposed prenatally to alcohol

Journal of Biomedical Science, 2011
Background A derived peptide from activity-dependent neurotrophic factor (ADNF-9) has been shown to be neuroprotective in the fetal alcohol exposure model.
Karty Jonathan A, YoussefAgha Ahmed, Segu Zaneer M, Sari Youssef, Isailovic Dragan   +4 more
doaj   +1 more source

Immunohistochemical detection of macrophage migration inhibitory factor in fetal and adult bovine epididymis: Release by the apocrine secretion mode? [PDF]

, 2006
Originally defined as a lymphokine inhibiting the random migration of macrophages, the macrophage migration inhibitory factor (MIF) is an important mediator of the host response to infection.
Agarwal A., Agrawal Y., Aumuller G., Bacher M., Bacher M., Bernhagen J., Bloom B.R., Bove S.E., Bronson R.A., Calandra T., Calandra T., Calandra T., Calne R.Y., Choufani G., Cooper T.G., Cropp C.S., David J.R., Eickhoff R., Eickhoff R., F. Sinowatz, Frenette G., Frenette G., Frenette G., G. Hoffbauer, G. Jennemann, Goyal H.O., H. Kaltner, H.-J. Gabius, Hoffer A.P., Howards S.S., Hudson J.D., J. Seitz, Kaltner H., Kaunisto K., Kirchhoff C., Kirchhoff C., Kleemann R., Legendre H., M.-P. Schüring, Manin M., Meinertz H., Meinhardt A., Meinhardt A., R. Eickhoff, Rosengren E., Seitz J., Steinhoff M., Sullivan R., Sun H.W., Suzuki M., Wada S., Wada S., Waeber G., Weiser W.Y., Wilhelm B., Zeng F.Y., Zeng F.Y., Zeng F.Y.   +57 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Proteomic profiling of human amnion for preterm birth biomarker discovery

Scientific Reports, 2021
Spontaneous preterm birth (PTB) complicates about 12% of pregnancies worldwide, remaining the main cause of neonatal morbidity and mortality. Spontaneous preterm birth PTBs is often caused by microbial-induced preterm labor, mediated by an inflammatory ...
Maurizio Bruschi, Martina Bartolucci, Andrea Petretto, Francesca Buffelli, Xhuliana Kajana, Alessandro Parodi, Riccardo Carbone, Ezio Fulcheri, Luca Antonio Ramenghi, Isabella Panfoli, Giovanni Candiano   +10 more
doaj   +1 more source

Prolactin Expression in the Baboon (Papio hamadryas) Eye

Animals, 2022
Prolactin (PRL) is a hormone expressed in lactotrophs cells of the pituitary gland in primates. Extra pituitary expression of PRL has been reported, including the eye; however, expression in the developing eye of primates is limited. The aim of the study
María Lourdes Garza-Rodríguez, Iram Pablo Rodríguez-Sanchez, Rafael González-Álvarez, Maricela Luna, Carlos Horacio Burciaga-Flores, Fernando Alcorta-Nuñez, Orlando Solis-Coronado, Víctor Manuel Bautista de Lucio, Genaro A. Ramírez-Correa, Oscar Vidal-Gutiérrez, Diana Cristina Pérez-Ibave   +10 more
doaj   +1 more source