Results 71 to 80 of about 59,586 (323)

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

Nature, 2017
Tissue-resident memory T (TRM) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological pathways that enable the long-term survival of TRM cells are obscure. Here we show that mouse CD8+ TRM
You-Dong Pan, T. Tian, C. Park, Serena Y. Lofftus, S. Mei, Xing Liu, C. Luo, J. O'Malley, A. Gehad, J. Teague, S. Divito, R. Fuhlbrigge, P. Puigserver, J. Krueger, Gökhan S. Hotamışlıgil, R. Clark, T. Kupper   +16 more
semanticscholar   +1 more source

Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States—Current View of Knowledge

Cells, 2022
Free fatty acids (FFAs) play numerous vital roles in the organism, such as contribution to energy generation and reserve, serving as an essential component of the cell membrane, or as ligands for nuclear receptors.
Katarzyna Lipke, A. Kubis-Kubiak, A. Piwowar   +2 more
semanticscholar   +1 more source

Electronic‐State Programming of Ultrasmall CeO2 Switches H2O2 Activation From Radical to Bio‐Inspired Nonradical 1O2 Generation for Combating Antibiotic Resistance

Advanced Science, EarlyView.
A scalable synthesis of carbon‐supported ultrasmall CeO2 nanoparticles with precisely tunable Ce electron density is reported. Electron‐lean Ce sites activate H2O2 exclusively via a nonradical pathway, enabling efficient HOBr and 1O2 production analogous to bromoperoxidase for contaminant and antibiotic resistance removal.
Bo Yuan, Xinyu Wu, Yin‐Song Liao, Chao Zhao, Zhanping Xiao, Wanqing Dai, Jyh‐Pin Chou, Wenchao Peng, Jian Lin Chen, Pi‐Tai Chou, Yung‐Kang Peng   +10 more
wiley   +1 more source

The Advancement of Selectivity in FFAs and TAGs [PDF]

Algae biofuels are being explored as a potential renewable fuel source due to their cost-effectiveness and environmental advantages. Certain algae species can produce triglycerides (TAGs) under nutrient-limited growth conditions.
Lewis, Toni Jade, Overstreet, Taylor
core   +1 more source

Fractionated free fatty acids and their relation to diabetes status after Roux‐en‐Y gastric bypass: A cohort study

Physiological Reports, 2021
Bariatric surgery is associated with near‐immediate remission of type 2 diabetes and recently suggested as a treatment for type 2 diabetes. Specifically, Roux‐en‐Y gastric bypass has been a focus of much research, but still, the mechanisms of action are ...
Freja Eriksen, Elin R. Carlsson, Jens K. Munk, Sten Madsbad, Mogens Fenger   +4 more
doaj   +1 more source

Saturated free fatty acids and association with memory formation [PDF]

, 2021
Changes in poly-unsaturated free fatty acids (FFAs) have been associated with LTP. Here, using lipidomics analysis the authors characterise FFA changes in the rat brain associated with fear conditioning, and demonstrate that increases in saturated FFAs ...
Vinod K. Narayana, François Windels, Alan Ho, Sah, P, David Kvaskoff, Bharat G. Venkatesh, Kvaskoff, D, Ho, A, Robert K. Sullivan, Narayana, VK, Sullivan, RK, Pankaj Sah, Windels, F, Meunier, FA, Venkatesh, BG, Tristan P. Wallis, Wallis, TP, Frédéric A. Meunier   +17 more
core   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways*

Journal of Biological Chemistry, 2007
Obesity and type 2 diabetes are characterized by decreased insulin sensitivity, elevated concentrations of free fatty acids (FFAs), and increased macrophage infiltration in adipose tissue (AT).
M. T. Audrey Nguyen, S. Favelyukis, Anh-Khoi Nguyen, D. Reichart, Peter A. Scott, A. Jenn, R. Liu-Bryan, Christopher K. Glass, Jaap G. Neels, J. Olefsky   +9 more
semanticscholar   +1 more source

Influence of FFA Activities on Critical Thinking Skills in Texas Three-Star FFA Chapters [PDF]

Journal of Agricultural Education, 2014
The purpose of this study was to determine the relationship of FFA activities on critical thinking skills of Texas FFA members in three-star FFA chapters. This descriptive study was conducted in eight purposively selected three-star FFA chapters throughout Texas. Three-star chapters are those chapters who have emerged as outstanding programs within the
Lindsey Latham, John Rayfield, Lori L. Moore   +2 more
openaire   +1 more source

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source