Results 11 to 20 of about 19,752 (209)

Lysophosphatidic Acid Synergizes With 1,25-Dihydroxyvitamin D to Promote Fibroblast Growth Factor-23 Synthesis via MAPK Signaling and Induction of the IL12A Gene. [PDF]

FASEB J
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Ay B, Cyr SM, Iwasaki Y, Hill E, Rhee EP, Singh NJ, Simic P, Bastepe M.   +7 more
europepmc   +2 more sources

Burosumab in Unidentifiable Tumor-Induced Osteomalacia. [PDF]

Clin Case Rep
ABSTRACT Tumor‐induced osteomalacia (TIO) can be challenging due to underlying tumors being either unresectable or unidentifiable. Burosumab, an anti‐FGF23 monoclonal antibody, has been proven to be effective in treating TIO but is currently not subsidized for this indication in Australia.
Der YS, Chaubey S, Mclean A, Trinh Y, Pember S, Sinha A.   +5 more
europepmc   +2 more sources

FGF23 signalling and physiology [PDF]

Journal of Molecular Endocrinology, 2021
Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in worms and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting it to proteolysis through subtilisin-like proprotein convertase FURIN, resulting in secretion of FGF23 fragments.
Bryan B, Ho, Clemens, Bergwitz
openaire   +2 more sources

αKlotho: FGF23 coreceptor and FGF23-regulating hormone [PDF]

Journal of Clinical Investigation, 2012
Low levels of phosphate can disrupt bone ossification and predispose to fractures. FGF23 is one of the major determinants of phosphate homeostasis, acting to increase urinary phosphate excretion. However, the regulation of FGF23 is incompletely understood. In this issue of the JCI, Smith et al.
Harald, Jüppner, Myles, Wolf
openaire   +2 more sources

FGF23 tumor induced osteomalacia

Problems of Endocrinology, 2022
Tumor induced osteomalacia is a rare acquired disease. The cause is a mesenchymal tumor secreting fibroblast growth factor 23 (FGF23). An excessive amount of FGF 23 disrupts the metabolism of phosphorus and vitamin D, which leads to severe paraneoplastic syndrome, manifested in the form of multiple fractures, severe pain in the bones and generalized ...
S. A. Gronskaia, Zh. E. Belaya, G. A. Melnichenko   +2 more
openaire   +2 more sources

Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia. [PDF]

PLoS ONE, 2013
The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) controls phosphate homeostasis by regulating renal expression of sodium-dependent phosphate co-transporters and cytochrome P450 enzymes involved in vitamin D catabolism. Multiple FGF Receptors (
Ai-Luen Wu, Bo Feng, Mark Z Chen, Ganesh Kolumam, Jose Zavala-Solorio, Shelby K Wyatt, Vineela D Gandham, Richard A D Carano, Junichiro Sonoda   +8 more
doaj   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X-Linked Hypophosphatemic Rickets. [PDF]

Adv Sci (Weinh)
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Wu H, Zhao W, Chen X, Wang Y, Wei S, Xiang B, Shi Y, Li Z, Yao Y, Xie J, Qiu R, Shu M, Xu S, Chen P, Chen Z, Wu Y, Xia W, Gao L, Song Y, Zhao J, Xu C.   +20 more
europepmc   +2 more sources

Protective Role of Vitamin D in Renal Tubulopathies

Metabolites, 2020
Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3.
Guido Gembillo, Valeria Cernaro, Rossella Siligato, Francesco Curreri, Antonino Catalano, Domenico Santoro   +5 more
doaj   +1 more source

Phosphopenic form of osteomalacia in a patient with FGF23 producing tumor

Научно-практическая ревматология, 2022
Oncogenic osteomalacia is an orphan disease caused by the overproduction of fibroblast growth factor 23 (FGF23) in tumors, which leads to impaired bone matrix mineralization. Typical laboratory changes are hypophosphatemia, increased alkaline phosphatase,
A. S. Pushkareva, E. E. Bibik, A. K. Eremkina, M. V. Degtyarev, N. G. Mokrysheva   +4 more
doaj   +1 more source

FGF23 Synthesis and Activity [PDF]

Current Molecular Biology Reports, 2019
The phosphaturic hormone FGF23 is produced primarily in osteoblasts/osteocytes and is known to respond to increases in serum phosphate and 1,25(OH)2 vitamin D (1,25D). Novel regulators of FGF23 were recently identified, and may help explain the pathophysiologies of several diseases.
Noonan, Megan L., White, Kenneth E.
openaire   +2 more sources