Results 21 to 30 of about 17,111 (223)
Promotion effect of FGF23 on osteopenia in congenital scoliosis through FGFr3/TNAP/OPN pathway
Chinese Medical Journal, 2023 . Background:. Congenital scoliosis (CS) is a complex spinal malformation of unknown etiology with abnormal bone metabolism. Fibroblast growth factor 23 (FGF23), secreted by osteoblasts and osteocytes, can inhibit bone formation and mineralization. This
Hongqi Zhang +8 more
doaj +1 more source
Nutrients, 2022 The seminal discoveries that parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) are major endocrine regulators of vitamin D metabolism led to a significant improvement in our understanding of the pivotal roles of peptide hormones and small
Nejla Latic, R. Erben
semanticscholar +1 more source
FGF23, alpha-Klotho and vitamin D mediated calcium-phosphate metabolism in haemodialysis patients [PDF]
Journal of Medical Biochemistry, 2021 Background: Klotho is a protein that acts as a co-receptor for FGF23. FGF23-Klotho axis has great importance regarding the regulation of mineral metabolism by kidneys.
Pasaoglu Ozge Tugce +4 more
doaj +1 more source
The regulation of FGF23 under physiological and pathophysiological conditions
Pflügers Archiv: European Journal of Physiology, 2022 Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates phosphate homeostasis in the kidney along with active vitamin D (1,25(OH)2D3) and parathyroid hormone (PTH).
Steffen Rausch, M. Föller
semanticscholar +1 more source
Plasma fibroblast growth factor 23 concentration is increased and predicts mortality in patients on the liver-transplant waiting list. [PDF]
PLoS ONE, 2013 High plasma fibroblast growth factor-23 (FGF23) concentration predicts the risk of death and poor outcomes in patients with chronic kidney disease or chronic heart failure.
Dominique Prié +9 more
doaj +1 more source
FGF23: A Review of Its Role in Mineral Metabolism and Renal and Cardiovascular Disease
Disease Markers, 2021 FGF23 is a hormone secreted mainly by osteocytes and osteoblasts in bone. Its pivotal role concerns the maintenance of mineral ion homeostasis. It has been confirmed that phosphate and vitamin D metabolisms are related to the effect of FGF23 and its ...
Anna Kurpas +3 more
semanticscholar +1 more source
FGF23 Synthesis and Activity [PDF]
Current Molecular Biology Reports, 2019 The phosphaturic hormone FGF23 is produced primarily in osteoblasts/osteocytes and is known to respond to increases in serum phosphate and 1,25(OH)2 vitamin D (1,25D). Novel regulators of FGF23 were recently identified, and may help explain the pathophysiologies of several diseases.
Noonan, Megan L., White, Kenneth E.
openaire +2 more sources
Protective Role of Vitamin D in Renal Tubulopathies
Metabolites, 2020 Vitamin D is tightly linked with renal tubular homeostasis: the mitochondria of proximal convoluted tubule cells are the production site of 1α,25-dihydroxyvitamin D3.
Guido Gembillo +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Fibroblast growth factor (FGF) 23 is elevated in chronic kidney disease (CKD) to maintain phosphate homeostasis. FGF23 is associated with left ventricular hypertrophy (LVH) in CKD and induces LVH via klotho-independent FGFR4-mediated activation of ...
Maren Leifheit-Nestler +17 more
doaj +1 more source
Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia. [PDF]
PLoS ONE, 2013 The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) controls phosphate homeostasis by regulating renal expression of sodium-dependent phosphate co-transporters and cytochrome P450 enzymes involved in vitamin D catabolism. Multiple FGF Receptors (
Ai-Luen Wu +8 more
doaj +1 more source