Results 21 to 30 of about 11,489 (185)
Frontiers in Cell and Developmental Biology, 2021 Fibroblast growth factor (FGF) 23 is elevated in chronic kidney disease (CKD) to maintain phosphate homeostasis. FGF23 is associated with left ventricular hypertrophy (LVH) in CKD and induces LVH via klotho-independent FGFR4-mediated activation of ...
Maren Leifheit-Nestler +17 more
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Interactions between FGF23 and vitamin D
Endocrine Connections, 2022 Fibroblast growth factor‐23 (FGF23) controls the homeostasis of both phosphate and vitamin D. Bone-derived FGF23 can suppress the transcription of 1α‐hydroxylase (1α(OH)ase) to reduce renal activation of vitamin D (1,25(OH)2D3).
Mohammed S Razzaque
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Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia. [PDF]
PLoS ONE, 2013 The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) controls phosphate homeostasis by regulating renal expression of sodium-dependent phosphate co-transporters and cytochrome P450 enzymes involved in vitamin D catabolism. Multiple FGF Receptors (
Ai-Luen Wu +8 more
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FGF23 Synthesis and Activity [PDF]
Current Molecular Biology Reports, 2019 The phosphaturic hormone FGF23 is produced primarily in osteoblasts/osteocytes and is known to respond to increases in serum phosphate and 1,25(OH)2 vitamin D (1,25D). Novel regulators of FGF23 were recently identified, and may help explain the pathophysiologies of several diseases.
Noonan, Megan L., White, Kenneth E.
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Disordered minerals and disease of soft tissue and bones in chronic kidney disease
African Journal of Nephrology, 2023 This article briefly reviews the mineral and bone disorder (MBD) found in patients with chronic kidney disease (CKD) and should provide a useful summary for trainees in nephrology and internal medicine.
Charles R Swanepoel
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FGF23, alpha-Klotho and vitamin D mediated calcium-phosphate metabolism in haemodialysis patients [PDF]
Journal of Medical Biochemistry, 2021 Background: Klotho is a protein that acts as a co-receptor for FGF23. FGF23-Klotho axis has great importance regarding the regulation of mineral metabolism by kidneys.
Pasaoglu Ozge Tugce +4 more
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World Journal of Nephrology, 2017 Systemic inflammation is a recognized feature in chronic kidney disease (CKD). The role of systemic inflammation in the pathogenesis of vascular calcification was recently settled. FGF23 was recently accused as a direct stimulus of systemic inflammation.
Sharaf El Din, Usama A A +2 more
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FGF23 and Phosphate–Cardiovascular Toxins in CKD
Toxins, 2019 Elevated levels of fibroblast growth factor 23 (FGF23) and phosphate are highly associated with increased cardiovascular disease and mortality in patients suffering from chronic kidney disease (CKD).
Isabel Vogt, Maren Leifheit-Nestler
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Frontiers in Cell and Developmental Biology, 2022 Enhanced fibroblast growth factor 23 (FGF23) is associated with left ventricular hypertrophy (LVH) in patients with chronic kidney and heart disease. Experimentally, FGF23 directly induces cardiac hypertrophy and vice versa cardiac hypertrophy stimulates
Fiona Eitner +10 more
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FGF23 as a calciotropic hormone [PDF]
F1000Research, 2015 Maintaining mineral metabolism requires several organs and hormones. Fibroblast growth factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of calcitriol – 1,25(OH) 2 D 3 – and induces phosphaturia.
María E. Rodríguez-Ortiz +1 more
openaire +2 more sources