Results 11 to 20 of about 17,111 (223)

FGF23 and Vitamin D Metabolism

JBMR Plus, 2021
Apart from its phosphaturic action, the bone‐derived hormone fibroblast growth factor‐23 (FGF23) is also an essential regulator of vitamin D metabolism. The main target organ of FGF23 is the kidney, where FGF23 suppresses transcription of the key enzyme ...
Nejla Latic, R. Erben
semanticscholar   +4 more sources

FGF23 signalling and physiology. [PDF]

Journal of Molecular Endocrinology, 2020
Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in C. elegans and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting to proteolysis
B. Ho, C. Bergwitz
semanticscholar   +3 more sources

Regulation of FGF23: Beyond Bone

Current Osteoporosis Reports, 2021
Fibroblast growth factor 23 (FGF23) is a bone- and bone marrow-derived hormone that is critical to maintain phosphate homeostasis. The principal actions of FGF23 are to reduce serum phosphate levels by decreasing kidney phosphate reabsorption and 1,25 ...
P. Simic, Jodie L Babitt
semanticscholar   +3 more sources

Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size

Endocrine Connections, 2021
Intrauterine growth restriction (IUGR) reflects inadequate growth in-utero and is prevalent in low resource settings. This study aimed to assess the association of maternal delivery parathyroid hormone (PTH) – a regulator of bone turnover and calcium ...
Huma Qamar, Nandita Perumal, Eszter Papp, Alison D Gernand, Abdullah Al Mahmud, Daniel E Roth   +5 more
doaj   +1 more source

Interdisciplinary management of FGF23-related phosphate wasting syndromes: a Consensus Statement on the evaluation, diagnosis and care of patients with X-linked hypophosphataemia

Nature Reviews Endocrinology, 2022
X-linked hypophosphataemia (XLH) is the most frequent cause of hypophosphataemia-associated rickets of genetic origin and is associated with high levels of the phosphaturic hormone fibroblast growth factor 23 (FGF23).
A. Trombetti, N. Al-Daghri, M. Brandi, J. Cannata-Andía, E. Cavalier, M. Chandran, C. Chaussain, Lucia Cipullo, C. Cooper, D. Haffner, P. Harvengt, N. Harvey, M. Javaid, F. Jiwa, J. Kanis, A. Laslop, M. R. Laurent, A. Linglart, A. Marques, Gabriel T. Mindler, S. Minisola, M. C. P. Yerro, M. Rosa, L. Seefried, M. Vlaskovska, M. Zanchetta, R. Rizzoli   +26 more
semanticscholar   +1 more source

Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation

Blood, 2023
Key Points • Osteocytes are the main source of Cter-FGF23 peptides in acute inflammation.• Bone-derived Cter-FGF23 peptides are iron conserving molecules and antagonize BMP-induced hepcidin production.
Guillaume Courbon, J. J. Thomas, Marta Martinez Calle, Xueyan Wang, Jadeah J. Spindler, John Von Drasek, B. Hunt-Tobey, Rupal C Mehta, Tamara Isakova, Wenhan Chang, J. Creemers, P. Ji, Aline Martin, V. David   +13 more
semanticscholar   +1 more source

FGF23 in Chronic Kidney Disease: Bridging the Heart and Anemia

Cells, 2023
Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced mainly in osteocytes. In chronic kidney disease (CKD) FGF23 levels increase due to higher production, but also as the result of impaired cleavage and reduced excretion from the body ...
Andreja Figurek, M. Rroji, G. Spasovski
semanticscholar   +1 more source

αKlotho: FGF23 coreceptor and FGF23-regulating hormone [PDF]

Journal of Clinical Investigation, 2012
Low levels of phosphate can disrupt bone ossification and predispose to fractures. FGF23 is one of the major determinants of phosphate homeostasis, acting to increase urinary phosphate excretion. However, the regulation of FGF23 is incompletely understood. In this issue of the JCI, Smith et al.
Harald, Jüppner, Myles, Wolf
openaire   +2 more sources

Clinical performance of a new intact FGF23 immunoassay in healthy individuals and patients with chronic hypophosphatemia

Bone Reports, 2023
While the positive association between automated intact fibroblast growth factor (FGF) 23 measurement kit (Determinar CL FGF23 [CL]) and the former assay (Kainos [KI]), and clinical utility of CL was well established, the clinical performance of ...
Hajime Kato, Hiromi Miyazaki, Takehide Kimura, Yoshitomo Hoshino, Naoko Hidaka, Minae Koga, Masaomi Nangaku, Noriko Makita, Nobuaki Ito   +8 more
doaj   +1 more source

The Measurement and Interpretation of Fibroblast Growth Factor 23 (FGF23) Concentrations

Calcified Tissue International, 2022
Two decades after the discovery of the hormone FGF23, we know more about phosphate homeostasis as it turned out that FGF23 is the central hormone that regulates this.
A. Heijboer, E. Cavalier
semanticscholar   +1 more source