Results 21 to 30 of about 19,752 (209)
A new metabolic path in type 3 rickets. [PDF]
FEBS JRickets, a bone disorder, was historically categorised into either nutritional (vitamin D deficiency) or genetic forms involving loss‐of‐function mutations in mineral metabolism. Recently, a new mechanism, type 3 rickets, was discovered to be caused by a gain‐of‐function mutation in CYP3A4 (Ile301Thr).
Senda T, Hirota Y.
europepmc +2 more sources
Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies [PDF]
, 2018 Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder of ectopic calcification due to deficiency of or resistance to intact fibroblast growth factor 23 (iFGF23). Inactivating
Burbelo +14 more
core +1 more source
FGF23 and Phosphate–Cardiovascular Toxins in CKD
Toxins, 2019 Elevated levels of fibroblast growth factor 23 (FGF23) and phosphate are highly associated with increased cardiovascular disease and mortality in patients suffering from chronic kidney disease (CKD).
Isabel Vogt, Maren Leifheit-Nestler
doaj +1 more source
Clinical Journal of the American Society of Nephrology, 2010 Chronic kidney disease (CKD) predisposes to cardiovascular disease (CVD), but the pathophysiologic mechanisms that drive this powerful association remain poorly defined despite intense investigation. The inability of randomized trials to demonstrate a benefit in patients with CKD of interventions that are known to reduce major cardiovascular events in ...
openaire +2 more sources
OR13-3 Effects of Iron Isomaltoside versus Ferric Carboxymaltose on Hormonal Control of Phosphate Homeostasis: The PHOSPHARE-IDA04/05 Randomized Controlled Trials [PDF]
, 2019 Iron isomaltoside (IIM) and ferric carboxymaltose (FCM) are newer intravenous iron preparations that can be administered in high-doses to rapidly correct iron deficiency anemia (IDA).
Achebe, Maureen +9 more
core +1 more source
World Journal of Nephrology, 2017 Systemic inflammation is a recognized feature in chronic kidney disease (CKD). The role of systemic inflammation in the pathogenesis of vascular calcification was recently settled. FGF23 was recently accused as a direct stimulus of systemic inflammation.
Sharaf El Din, Usama A A +2 more
openaire +2 more sources
The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]
, 2017 α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles +4 more
core +1 more source
Left Ventricular Hypertrophy in Patients with X-Linked Hypophosphataemia
JCRPE, 2022 X-linked hypophosphatemia (XLH) is a rare genetic disorder with X-linked dominant inheritance. Mutations in the PHEX gene increase fibroblast growth factor 23 (FGF23) concentrations, causing loss of phosphorus at the proximal tubule.
Ana Castellano-Martinez +3 more
doaj +1 more source
Vitamin D. a dynamic molecule. how relevant might the dynamism for a vitamin be [PDF]
, 2015 Cholecalciferol, the precursor of Vitamin D3, is a very old, highly conserved, molecule. Its presence is evident in non-mineralized 750 million-year-old living species, such as plankton.
Mazzaferro, Sandro, Pasquali, Marzia
core +2 more sources
FGF23 production by osteocytes [PDF]
Pediatric Nephrology, 2012 Fibroblast growth factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease.
Lynda F, Bonewald, Michael J, Wacker
openaire +2 more sources