Results 71 to 80 of about 19,752 (209)

Targeted Alkaline Phosphatase Therapy Enhances Alveolar Bone Healing in X‐Linked Hypophosphatemia in Mice

Journal of Periodontal Research, EarlyView.
Effects of exogenous tissue‐nonspecific alkaline phosphatase (TNAP) were analyzed in the Hyp mouse model of X‐linked hypophosphatemia (XLH). Maxillary first molars were extracted from wild‐type (WT) and Hyp mice at 6 weeks, and collagen gel ± TNAP was placed in sockets. In one group of Hyp mice, submucosal injections of TNAP or saline were delivered at
Aonjittra Phanrungsuwan, Bella Donnelly, José Luis Millán, Brian L. Foster   +3 more
wiley   +1 more source

Physiological Actions of Fibroblast Growth Factor-23

Frontiers in Endocrinology, 2018
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney. At physiological concentrations of the hormone, the endocrine actions of FGF23 in the kidney are αKlotho ...
Reinhold G. Erben
doaj   +1 more source

FGF23 metabolism, a new paradigm for chronic kidney disease [PDF]

, 2015
Introduction:  Fibroblast growth factor-23 (FGF23) is a major regulator of phosphate metabolism often elevated in genetic hypophosphataemic disorders and in chronic kidney disease.
Fraser, William, Nicholls, Holly, Piec, Isabelle, Tang, Jonathan, Washbourne, Christopher   +4 more
core  

Circulating αKlotho influences phosphate handling by controlling FGF23 production [PDF]

, 2012
The FGF23 coreceptor αKlotho (αKL) is expressed as a membrane-bound protein (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to initiate intracellular signaling.
Allen, Matthew R., Breyer, Matthew D, Broderick, Carol, Burr, David B., Cass, Taryn A, Clinkenbeard, Erica L., Farrow, Emily G, Guo, Qianxu, Kharitonenkov, Alexei, Ma, Y Linda, O'Bryan, Linda M, Roberts, Jessica L, Saha, Joy, Smith, Rosamund C, Summers, Lelia J, Sun, Haijun, White, Kenneth E, Wilson, Jonathan M, Zeng, Qing Qiang   +18 more
core   +1 more source

Genetic and Molecular Determinants of Familial Transmission of Skeletal Malocclusions

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Families studies conducted in different ethnic populations worldwide have helped elucidate the molecular and genetic factors involved in the development of skeletal class III malocclusion. Therefore, the aim of this study is to provide an updated summary.
Alexandra Dehesa‐Santos, Lucia Carreño‐Gomez, Rosa Yañez‐Vico, Alejandro Iglesias‐Linares   +3 more
wiley   +1 more source

A Case of Tumor-Induced Osteomalacia Detected by Venous Sampling

International Medical Case Reports Journal, 2023
Yasuo Horinouchi, Seiji Shiota, Ryo Kaimori, Katsuhiko Yoshimura, Rie Utsunomiya-Nishimizu, Kyoko Yamamoto, Eishi Miyazaki Department of General Medicine, Oita University Faculty of Medicine, Yufu, Oita, 879-5593, JapanCorrespondence: Seiji Shiota ...
Horinouchi Y, Shiota S, Kaimori R, Yoshimura K, Utsunomiya-Nishimizu R, Yamamoto K, Miyazaki E   +6 more
doaj  

Relationship of Fibroblast Growth Factor 23 Serum Levels with Disease Characteristics in Systemic Lupus Erythematosus Patients

Biomolecules, 2023
Fibroblast growth factor 23 (FGF23), a hormone secreted by osteocytes and osteoblasts, is a major regulator of vitamin D and phosphate homeostasis. FGF23 has been associated with the disturbance of mineral homeostasis, and with kidney and cardiovascular ...
Yolanda Fernández-Cladera, Fuensanta Gómez-Bernal, María García-González, Juan C. Quevedo-Abeledo, Agustín F. González-Rivero, Antonia de Vera-González, Candelaria Martín-González, Ana L. Nunes-Andrade, Raquel López-Mejías, Miguel Á. González-Gay, Iván Ferraz-Amaro   +10 more
doaj   +1 more source

From variome to phenome : pathogenesis, diagnosis and management of ectopic mineralization disorders [PDF]

, 2015
Ectopic mineralization - inappropriate biomineralization in soft tissues - is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality.
De Vilder, eva, Vanakker, Olivier
core   +2 more sources

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

The Clinical Value of Klotho and FGF23 in Cardiac Valve Calcification Among Patients with Chronic Kidney Disease

International Journal of General Medicine, 2021
Yan Chen, Yan-Xia Chen, Chong Huang, Zhi-Bing Duan, Cheng-Yun Xu Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, People’s Republic of ChinaCorrespondence: Yan ChenDepartment of ...
Chen Y, Chen YX, Huang C, Duan ZB, Xu CY
doaj