Results 161 to 170 of about 32,832 (202)

Fibroblast growth factor receptor inhibition for succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 2 trial. [PDF]

Nat Med
Merriam P, Morrow JJ, Mazzola E, Solimini NL, Gokhale PC, Chi P, Chen AP, Agulnik M, Burgess M, Schuetze SM, Somaiah N, Van Tine BA, Pollack SM, Tinoco G, Trent J, Wilky BA, Bothwick N, Eschle BK, Nguyen V, Beumer JH, Rastkari N, Jiwani S, Wu PI, Pelosof L, Hemming ML, Shapiro GI, Demetri G, Bernstein B, George S.   +28 more
europepmc   +1 more source

Erdafitinib or Erdafitinib Plus Cetrelimab for Patients With Metastatic Urothelial Carcinoma and <i>FGFR</i> Alterations: Final Results From the Phase II NORSE Study. [PDF]

J Clin Oncol
Loriot Y, Powles T, Moreno V, Kang TW, Cicin I, Girvin A, Akapame S, O'Hagan A, Zhu W, Tammaro M, Thomas S, Triantos S, Siefker-Radtke AO.   +12 more
europepmc   +1 more source

Current Status of Drug Treatment of Cholangiocarcinoma-Updated Progress and Critical Limitations. [PDF]

Pharmaceuticals (Basel)
Cillis J, Chen C, Deshpande S, Fong Y, Chaurasiya S.   +4 more
europepmc   +1 more source

Development of an extended version of GALEAS bladder: Detection of FGFR3 fusions in urine and associations between genomic alterations and gene expression. [PDF]

Bladder Cancer
Neil JL, Gordon NS, Goel A, Myumyun AN, Tura B, de Jong JJ, Davicioni E, Zeegers MP, Cheng KK, James ND, Neou M, Arnold R, Bryan RT, Ward DG.   +13 more
europepmc   +1 more source

Current Landscape and Evolving Role of Targeted Agents in Urothelial Carcinoma. [PDF]

Cancers (Basel)
Sammarco E, Pellino A, Bona E, Farnesi A, Biasco E, Caparello C, Marini A, Stasi I, Musettini G, Barbara C, De Maio E, Coltelli L, Cupini S, Allegrini G.   +13 more
europepmc   +1 more source

FGFR signaling and endocrine resistance in breast cancer: Challenges for the clinical development of FGFR inhibitors

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been extensively investigated in solid malignancies, representing an attractive therapeutic target. In breast cancer, especially in estrogen receptor positive (ER+) subtype, FGFR signaling aberrations have been reported to contribute to proliferation, dedifferentiation, metastasis and ...
Servetto A., Formisano L., Arteaga C. L.
openaire   +4 more sources

FGFR Fusions in Cancer: From Diagnostic Approaches to Therapeutic Intervention

International Journal of Molecular Sciences, 2020
Fibroblast growth factor receptors (FGFRs) are tyrosine kinase receptors involved in many biological processes. Deregulated FGFR signaling plays an important role in tumor development and progression in different cancer types.
Antonella De Luca, Riziero Esposito Abate, Anna Maria Rachiglio   +2 more
exaly   +2 more sources

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FGFR Mutations and Plagiocephaly

Journal of Craniofacial Surgery, 2008
FGFR genes have important effects on bone development, and mutations in 4 "hot spot" exons of FGFR1-3 are found in many patients with craniosynostosis and some with synostotic plagiocephaly. To test the hypothesis that sequence variation in those exons predisposes toward developmental bone deformation, we assayed 160 children with nonsynostotic ...
Valairat, Dhamcharee, Richard G, Boles
openaire   +2 more sources

The Hydra FGFR, Kringelchen, partially replaces the Drosophila Heartless FGFR

Development Genes and Evolution, 2012
Fibroblast growth factor receptors (FGFR) are highly conserved receptor tyrosine kinases, and evolved early in metazoan evolution. In order to investigate their functional conservation, we asked whether the Kringelchen FGFR in the freshwater polyp Hydra vulgaris, is able to functionally replace FGFR in fly embryos.
Anja, Rudolf, Christine, Hübinger, Katrin, Hüsken, Angelika, Vogt, Nicole, Rebscher, Susanne-Filiz, Onel, Renate, Renkawitz-Pohl, Monika, Hassel   +7 more
openaire   +2 more sources

FGFR signalling in women's cancers

The International Journal of Biochemistry & Cell Biology, 2013
FGFs, in a complex with their receptors (FGFRs) and heparan sulfate (HS), are responsible for a range of cellular functions, from embryogenesis to metabolism. Both germ line and somatic FGFR mutations are known to play a role in a range of diseases, most notably craniosynestosis dysplasias, dwarfism and cancer. Because of the ability of FGFR signalling
Abbie E, Fearon, Charlotte R, Gould, Richard P, Grose   +2 more
openaire   +2 more sources