Results 141 to 150 of about 35,836 (258)
Dual‐Targeted Trimyristin Nanoemulgel Accelerates Burn Wound Healing via VEGFR and FGFR Modulation [PDF]
Chem BiodiversThe graphical abstract encapsulates the formulation of a trimyristin‐loaded O/W nanoemulgel and its dual‐targeted mechanism for burn wound healing. Trimyristin had significant affinity for VEGFR and FGFR, promoting angiogenesis, collagen production, and re‐epithelialization, while inhibiting inflammation and oxidative stress, so expediting tissue ...
Sinha A +4 more
europepmc +2 more sources
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
, 2014 Background: Lung cancer is the top cancer killer. Squamous cell lung carcinoma (SCC) represents the second most common histologic subtype of lung cancer.
Lam, SK +4 more
core
Journal of Cosmetic Dermatology, Volume 25, Issue 11, November 2026.ABSTRACT Background Calcium hydroxylapatite (CaHA)‐based fillers act as both volumizing agents and bioactive scaffolds capable of inducing matrix synthesis and dermal remodeling. Their rheological properties and biological activity can be modulated via dilution strategies, expanding their applicability in regenerative and aesthetic medicine.
Eduardo Anitua +2 more
wiley +1 more source
FGFR pathway genomic aberrations and response to FGFRs inhibitors
Annals of Oncology, 2017 M. Faure +4 more
openaire +1 more source
The FASEB Journal, Volume 40, Issue 20, 31 October 2026.A maternal western diet (WD) and betaine supplementation during suckling influence metabolic programming. A maternal WD induced adverse metabolic effects in offspring, accompanied by altered FGF21‐related gene expression and decreased Akkermansia muciniphila abundance.
Rocío A. Martín‐Chamorro +4 more
wiley +1 more source
Fibroblast growth factor receptor (FGFR) alteration is one of the common driver alterations in urothelial carcinoma (UC). FGFR alterations contribute to anti-tumor immunity inhibition and are associated with attenuated response to immune checkpoint ...
Yiqing Du +5 more
core +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Breast Cancer ResearchFibroblast growth factors (FGFs) control various cellular functions through fibroblast growth factor receptor (FGFR) activation, including proliferation, differentiation, migration, and survival.
Feng Chi +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 57, 14 October 2026.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source