Results 131 to 140 of about 34,994 (236)

Syntaxin 12 Sustains Endosomal‐Lysosomal Homeostasis and Survival in Glioblastoma Stem‐Like Cells

Traffic, Volume 27, Issue 3, September 2026.
Syntaxin12 maintains endolysosomal trafficking and lysosomal homeostasis in glioblastoma cells. Syntaxin12 depletion disrupts lysosomal organization, impairs endolysosomal progression and mTOR‐lysosome communication, and compromises adaptive pathways required for cell survival. ABSTRACT Glioblastoma cells display a striking vulnerability to disruptions
Clément Maghe, Agnieszka Barbach, Gwennan André‐Grégoire, Clotilde C. N. Renaud, Margaux Le Guyon, Rosalie Moreau, Nicolas Bidère, Julie Gavard   +7 more
wiley   +1 more source

Comparative Response of Canine and Human Osteosarcoma Tumour Cell Lines to Molecularly Targeted Anticancer Agents at Clinically Relevant Exposures With Analysis of Genomic Biomarkers

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 532-544, September 2026.
ABSTRACT Osteosarcoma (OSA) is a primary bone tumour occurring in children but is also prevalent in large breed dogs. Canine OSA (cOSA) has long been viewed as analogous to human OSA (hOSA) with cOSA serving as a surrogate for development of therapeutic approaches to treat the rarer human form.
Daniel L. Gustafson, Kala A. Early, Maritza A. Morales, Klaudia A. Poplawski, Sunetra Das, Dawn L. Duval   +5 more
wiley   +1 more source

FGFR pathway genomic aberrations and response to FGFRs inhibitors

Annals of Oncology, 2017
M. Faure, A. Hollebecque, R. Bahleda, J-C. Soria, V. Dyevre   +4 more
openaire   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

CPTCs Drive Somatic‐Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single‐Cell Deep Learning Study

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Using an interpretable deep learning framework (CARSS) applied to multi‐tissue single‐cell RNA sequencing, we identify CD34⁺PDGFRα⁺ telocytes (CPTCs) as the primary mechanosensors bridging somatic acupuncture stimulation and visceral repair. Mechanical force at acupoints activates an AP‐1/Hsp70 immediate‐early gene program in fascial CPTCs, triggering ...
Haixiang Huang, Zhenwei Zhang, Bingbing Shen, Jianming Yue, Lu Mei, Xudong Zhu, Yonghong Shi, Qianmei Zhu, Yeping Shi, Yifan Luo, Yitong Xing, Meng Dai, Qiusheng Chen   +12 more
wiley   +1 more source

Paradoxical cancer cell proliferation after FGFR inhibition through decreased p21 signaling in FGFR1-amplified breast cancer cells

Breast Cancer Research
Fibroblast growth factors (FGFs) control various cellular functions through fibroblast growth factor receptor (FGFR) activation, including proliferation, differentiation, migration, and survival.
Feng Chi, Jason I. Griffiths, Aritro Nath, Andrea H. Bild   +3 more
doaj   +1 more source

FGFR Inhibitor [PDF]

, 2020
openaire   +1 more source

FGFR Inhibition [PDF]

, 2020
openaire   +1 more source

Second-Generation FGFR Inhibitors for the Treatment of Cancers Harboring Mutated FGFRs [PDF]

ACS Medicinal Chemistry Letters, 2019
openaire   +2 more sources

Prognostic and clinicopathologic significance of FGFR mRNA and protein overexpression in colorectal cancer: a systematic review and meta-analysis. [PDF]

Transl Cancer Res
Chai X, Li C, Luo Y, Shen Q, Wu S, Huang Q.   +5 more
europepmc   +1 more source